Results 21 to 30 of about 2,149 (84)

Identification of aberrantly methylated differentially expressed genes and associated pathways in endometrial cancer using integrated bioinformatic analysis

Cancer Medicine, Volume 9, Issue 10, Page 3522-3536, May 2020., 2020
This research inferred potential aberrantly methylated DEGs and dysregulated pathways may participate in EC development and firstly reported 8 hub genes, including EDNRB, CDO1, NDN, PLCD1, ROR2, ESPL1, PRAME and PTTG1 that could be used to predict EC prognosis. Aminoglutethimide and luteolin may be used to fight against EC. Abstract Endometrial cancer (
JinHui Liu, YiCong Wan, Siyue Li, HuaiDe Qiu, Yi Jiang, Xiaoling Ma, ShuLin Zhou, WenJun Cheng   +7 more
wiley   +1 more source

Calcium transcriptionally regulates movement, recombination and other functions of Xylella fastidiosa under constant flow inside microfluidic chambers

Microbial Biotechnology, Volume 13, Issue 2, Page 548-561, March 2020., 2020
Whole transcriptome analysis was conducted on cells of the bacterial plant pathogen Xylella fastidiosa grown inside microfluidic chambers. Comparison of cells grown in synthetic media with or without supplemental calcium (Ca) revealed that Ca regulates movement and other virulence factors of this pathogen under flow conditions.
Hongyu Chen, Leonardo De La Fuente
wiley   +1 more source

Mammalian TatD DNase domain containing 1 (TATDN1) is a proteostasis‐responsive gene with roles in ventricular structure and neuromuscular function

The FEBS Journal, Volume 292, Issue 19, Page 5105-5129, October 2025.
Twin‐arginine translocation D (TatD) homologs are found across all kingdoms, with debated roles in DNA degradation and protein quality control in unicellular organisms. We characterize TATDN1, the mammalian TatD orthologue, as a proteostatic stress‐responsive cytosolic protein dispensable for DNA degradation.
Gisel Barés, Aida Beà, Anna Sancho‐Balsells, Juan G Valero, David Aluja, Javier Inserte, Sandra García‐Carpi, Elisabet Miró‐Casas, Sara Borràs‐Pernas, Sara Hernández, Ana Martínez‐Val, Jesper V Olsen, Francesc Tebar, Xavier Cañas, Joan X. Comella, Patricia Pérez‐Galán, Marisol Ruiz‐Meana, Albert Giralt, Marta Llovera, Daniel Sanchis   +19 more
wiley   +1 more source

Cyanophage Infections in a Sponge Intracellular Cyanobacterial Symbiont

Environmental Microbiology, Volume 27, Issue 7, July 2025.
Intracellular cyanobacterial symbionts of sponges are shown to be susceptible to cyanophages, challenging assumptions about their isolation from viral exposure. The study reveals novel phage–host interactions and suggests conserved infection strategies across symbionts of marine and terrestrial animals.
Tzipora Peretz, Esther Cattan‐Tsaushu, Chiara Conti, Benyamin Rosental, Laura Steindler, Sarit Avrani   +5 more
wiley   +1 more source

Identification and characterization of OmpT‐like proteases in uropathogenic Escherichia coli clinical isolates

MicrobiologyOpen, Volume 8, Issue 11, November 2019., 2019
Here, we investigated omptin protease‐mediated antimicrobial resistance among uropathogenic Escherichia coli clinical isolates. We found that clinical isolates with the highest omptin protease activity encode multiple omptin proteases, showing different substrate specificities. Our data suggest that the presence of multiple omptin family proteases in a
Isabelle Desloges, James A. Taylor, Jean‐Mathieu Leclerc, John R. Brannon, Andrea Portt, John D. Spencer, Ken Dewar, Gregory T. Marczynski, Amee Manges, Samantha Gruenheid, Hervé Le Moual, Jenny‐Lee Thomassin   +11 more
wiley   +1 more source

Improvement in genomic prediction of maize with prior gene ontology information depends on traits and environmental conditions

The Plant Genome, Volume 18, Issue 1, March 2025.
Abstract Classical genomic prediction approaches rely on statistical associations between traits and markers rather than their biological significance. Biologically informed selection of genomic regions can help prioritize polymorphisms by considering underlying biological processes, making prediction models robust and accurate.
Baber Ali, Tristan Mary‐Huard, Alain Charcosset, Laurence Moreau, Renaud Rincent   +4 more
wiley   +1 more source

Association of DNA Repair Gene APE1 Asp148Glu Polymorphism with Breast Cancer Risk

Disease Markers, Volume 2015, Issue 1, 2015., 2015
Objective. The aim of this study was to investigate the role of APE1 Asp148Glu polymorphism in breast cancer progression in Saudi population. Methods. We examined the genetic variations (rs1130409) in the DNA base excision repair gene APE1 at codon 148 (Asp148Glu) and its association with breast cancer risk using genotypic assays and in silico ...
Fatima AlMutairi, Akbar Ali Khan Pathan, Mohammed Alanazi, Manal Shalaby, Huda A. Alabdulkarim, Abdullah Alamri, Abdulrahman Al Naeem, Moammad Elrobh, Jilani P. Shaik, Wajahatullah Khan, Zahid Khan, Narasimha Reddy Parine, Andreas Pich   +12 more
wiley   +1 more source

Supplementation of lactobacillus‐fermented rapeseed meal in broiler diet reduces Campylobacter jejuni cecal colonization and limits the l‐tryptophan and l‐histidine biosynthesis pathways

Journal of the Science of Food and Agriculture, Volume 104, Issue 9, Page 5474-5485, July 2024.
Abstract BACKGROUND Campylobacter jejuni (C. jejuni), a widely distributed global foodborne pathogen, primarily linked with contaminated chicken meat, poses a significant health risk. Reducing the abundance of this pathogen in poultry meat is challenging but essential.
Farina Khattak, Salvatore Galgano, Ninfa Rangel Pedersen, Yan Hui, Rikke Matthiesen, Jos Houdijk   +5 more
wiley   +1 more source

A novel peptide interferes with Mycobacterium tuberculosis virulence and survival

FEBS Open Bio, Volume 4, Issue 1, Page 735-740, January 01, 2014., 2014
Tuberculosis (TB) is a huge global burden, with new and resistant strains emerging at an alarming rate, necessitating an urgent need for a new class of drug candidates. Here, we report that SL3, a novel 33‐amino acid peptide, causes debilitating effects on mycobacterial morphology.
Sachin Kumar Samuchiwal, Sultan Tousif, Dhiraj Kumar Singh, Arun Kumar, Anamika Ghosh, Kuhulika Bhalla, Prem Prakash, Sushil Kumar, Ashish Chandra Trivedi, Maitree Bhattacharyya, Gobardhan Das, Anand Ranganathan   +11 more
wiley   +1 more source

Highly Sensitive Fluorescent Detection of HPV-16 DNA Using Tungsten Disulfide Nanosheets and Exonuclease III-Assisted Signal Amplification. [PDF]

Biosensors (Basel)
Wu M, Lin G, Dong J, Zeng A, Hong H, Chen Z, Hong C.   +6 more
europepmc   +1 more source