Results 1 to 10 of about 18,119 (268)
To cleave or not and how? The DNA exonucleases and endonucleases in immunity [PDF]
Genes and DiseasesDNA exonucleases and endonucleases are key executors of the genome during many physiological processes. They generate double-stranded DNA by cleaving damaged endogenous or exogenous DNA, triggering the activation of the innate immune pathways such as ...
Teng
exaly +4 more sources
BacPE: a versatile prime-editing platform in bacteria by inhibiting DNA exonucleases [PDF]
Nature CommunicationsPrime editing allows precise installation of any single base substitution and small insertions and deletions without requiring homologous recombination or double-strand DNA breaks in eukaryotic cells.
Zhaowei Wu, Quanjiang Ji
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5PSeq Explorer: interactive analysis of co-translational mRNA decay and ribosome dynamics [PDF]
RNA BiologyCo-translational mRNA decay occurs when 5’to3’ exonucleases follow the last translating ribosome, generating in vivo ribosome protected fragments. Degradome sequencing (5PSeq)therefore offers unique insights into ribosome dynamics. Despite its potential,
Irene Stevens, Vicent Pelechano
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Mechanistic insights into single-stranded DNA degradation by lysosomal exonucleases PLD3 and PLD4 from structural snapshots [PDF]
Nature CommunicationsLysosomal exonuclease phospholipase D (PLD) family PLD3 and PLD4 degrade single-stranded RNA or DNA and regulate TLR7 or TLR9 responses. Polymorphisms of these enzymes are associated with human diseases: PLD4 is associated with inflammatory diseases, and
Yoshinori Hirano +5 more
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Viruses, 2022 In this review, we explore recombination in two very different virus families that have become major threats to human health. The Herpesviridae are a large family of pathogenic double-stranded DNA viruses involved in a range of diseases affecting both ...
Lee R. Wright +2 more
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Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
IUCrJ, 2022 Arenaviruses are emerging enveloped negative-sense RNA viruses that cause neurological and hemorrhagic diseases in humans. Currently, no FDA-approved vaccine or therapeutic agent is available except for ribavirin, which must be administered early during ...
Thi Hong Van Nguyen +5 more
doaj +1 more source
Viruses, 2023 Nucleases are ubiquitous hydrolytic enzymes that cleave phosphodiester bond of DNA (DNases), RNA (RNases), or protein-RNA/DNA (phosphodiesterases), within the strand (endonucleases) or from the end (exonucleases) [...]
Zhengqiang Wang, Robert J. Geraghty
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Exonucleases: Degrading DNA to Deal with Genome Damage, Cell Death, Inflammation and Cancer
Cells, 2022 Although DNA degradation might seem an unwanted event, it is essential in many cellular processes that are key to maintaining genomic stability and cell and organism homeostasis.
Joan Manils +2 more
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Recent insights into the structure and function of coronavirus ribonucleases
FEBS Open Bio, 2022 Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response.
Meredith N. Frazier +4 more
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Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease. [PDF]
PLoS ONE, 2012 Lassa virus causes hemorrhagic fever characterized by immunosuppression. The nucleoprotein of Lassa virus, termed NP, binds the viral genome. It also has an additional enzymatic activity as an exonuclease that specifically digests double-stranded RNA ...
Kathryn M Hastie +3 more
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