ARGONAUTE10 promotes the degradation of miR165/6 through the SDN1 and SDN2 exonucleases in Arabidopsis. [PDF]
PLoS Biology, 2017 The degradation of small RNAs in plants and animals is associated with small RNA 3' truncation and 3' uridylation and thus relies on exonucleases and nucleotidyl transferases.
Yu Yu +12 more
doaj +2 more sources
Directional translocation resistance of Zika xrRNA [PDF]
Nature Communications, 2020 Zika xrRNAs survive in host cells because they can be unwound and copied by replicases, but resist degradation by exonucleases. Here authors use atomistic models and simulations and uncover that pulling into a pore the xrRNA $${3}^{\prime}$$ 3′ end, as ...
Antonio Suma +3 more
doaj +2 more sources
BacPE: a versatile prime-editing platform in bacteria by inhibiting DNA exonucleases
Nature CommunicationsPrime editing allows precise installation of any single base substitution and small insertions and deletions without requiring homologous recombination or double-strand DNA breaks in eukaryotic cells.
Hongyuan Zhang +10 more
doaj +2 more sources
A role for 3’ exonucleases at the final stages of chromosome duplication in Escherichia coli [PDF]
, 2018 Chromosome duplication initiates via the assembly of replication fork complexes at defined origins, from where they proceed in opposite directions until they fuse with a converging fork.
Rudolph, C, Midgley-Smith, S, Dimude, J
core +5 more sources
Recent insights into the structure and function of coronavirus ribonucleases
FEBS Open Bio, 2022 Coronaviruses use approximately two‐thirds of their 30‐kb genomes to encode nonstructural proteins (nsps) with diverse functions that assist in viral replication and transcription, and evasion of the host immune response.
Meredith N. Frazier +4 more
doaj +1 more source
Structural basis for the dsRNA specificity of the Lassa virus NP exonuclease. [PDF]
PLoS ONE, 2012 Lassa virus causes hemorrhagic fever characterized by immunosuppression. The nucleoprotein of Lassa virus, termed NP, binds the viral genome. It also has an additional enzymatic activity as an exonuclease that specifically digests double-stranded RNA ...
Kathryn M Hastie +3 more
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Pre-Ribosomal RNA Processing in Human Cells: From Mechanisms to Congenital Diseases
Biomolecules, 2018 Ribosomal RNAs, the most abundant cellular RNA species, have evolved as the structural scaffold and the catalytic center of protein synthesis in every living organism.
Maxime Aubert +3 more
doaj +1 more source
The MicroRNA Family Gets Wider: The IsomiRs Classification and Role
Frontiers in Cell and Developmental Biology, 2021 MicroRNAs (miRNAs or miRs) are the most characterized class of non-coding RNAs and are engaged in many cellular processes, including cell differentiation, development, and homeostasis.
Luisa Tomasello +3 more
doaj +1 more source
Rrp47p is an exosome-associated protein required for the 3 ' processing of stable RNAs [PDF]
, 2003 Related exosome complexes of 3'-->5' exonucleases are present in the nucleus and the cytoplasm. Purification of exosome complexes from whole-cell lysates identified a Mg2+-labile factor present in substoichiometric amounts. This protein was identified
Tollervey, D +4 more
core +1 more source
ISG20: an enigmatic antiviral RNase targeting multiple viruses
FEBS Open Bio, 2022 Interferon‐stimulated gene 20 kDa protein (ISG20) is a relatively understudied antiviral protein capable of inhibiting a broad spectrum of viruses. ISG20 exhibits strong RNase properties, and it belongs to the large family of DEDD exonucleases, present ...
Séverine Deymier +3 more
doaj +1 more source