Results 21 to 30 of about 12,706 (198)
Медицинская иммунология, 2020 The following specificcharacteristics of the composition of intestinal microbiota in patients with irritable bowel syndrome (IBS) were identified using a metagenomic analysis (16 S rRNA): 1) an increase in the representation of Actinobacteria, including ...
E. I. Ermolenko +9 more
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Structural analysis of viral ExoN domains reveals polyphyletic hijacking events.
PLoS ONE, 2021 Nidoviruses and arenaviruses are the only known RNA viruses encoding a 3'-5' exonuclease domain (ExoN). The proofreading activity of the ExoN domain has played a key role in the growth of nidoviral genomes, while in arenaviruses this domain partakes in ...
Adrián Cruz-González +8 more
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PLoS Biology, 2021 [This corrects the article DOI: 10.1371/journal.pbio.2001272.].
Yu Yu +12 more
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CATALYTIC PROPERTIES OF THE EUKARYOTIC EXOSOME [PDF]
, 2010 The eukaryotic exosome complex is built around the backbone of a 9‑subunit ring similar to phosporolytic ribonucleases such as RNase PH and polynucleotide phosphorylase (PNPase).
Séraphin, Bertrand +4 more
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A comprehensive review of circRNA: from purification and identification to disease marker potential [PDF]
PeerJ, 2018 Circular RNA (circRNA) is an endogenous noncoding RNA with a covalently closed cyclic structure. Based on their components, circRNAs are divided into exonic circRNAs, intronic circRNAs, and exon-intron circRNAs. CircRNAs have well-conserved sequences and
Sheng Xu +8 more
doaj +2 more sources
DnaQ mediates directional spacer acquisition in the CRISPR-Cas system by a time-dependent mechanism
The Innovation, 2023 In the spacer acquisition stage of CRISPR-Cas immunity, spacer orientation and protospacer adjacent motif (PAM) removal are two prerequisites for functional spacer integration. Cas4 has been implicated in both processing the prespacer and determining the
Dongmei Tang +9 more
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PLoS Biology, 2014 DNA repair mechanisms are essential for preservation of genome integrity. However, it is not clear how DNA are selected and processed at broken ends by exonucleases during repair pathways.
Yu-Yuan Hsiao +4 more
doaj +1 more source
The Rtr1p CTD phosphatase autoregulates its mRNA through a degradation pathway involving the REX exonucleases. [PDF]
, 2016 Rtr1p is a phosphatase that impacts gene expression by modulating the phosphorylation status of the C-terminal domain of the large subunit of RNA polymerase II. Here, we show that Rtr1p is a component of a novel mRNA degradation pathway that promotes its
Chanfreau, Guillaume +2 more
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, 2017 International audienceRecently, we described a method for multiplex genome editing by natural transformation (MuGENT). Mutant constructs for MuGENT require large arms of homology (\textgreater2000 bp) surrounding each genome edit, which necessitates ...
Ankur B. Dalia +11 more
core +2 more sources
, 2000 The final stage in the formation of the two large subunit rRNA species in Saccharomyces cerevisiae is the removal of internal transcribed spacer 2 (ITS2) from the 27SB precursors. This removal is initiated by endonucleolytic cleavage approximately midway
Vos, J.C.; id_orcid +3 more
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