Results 41 to 50 of about 18,119 (268)
The pendulum of the Ku-Ku clock [PDF]
, 2018 Canonical DNA non-homologous end-joining (c-NHEJ) and homologous recombination (HR), the two major DNA double-strand break (DSB) repair pathways, have long been depicted as competitors, fighting a race to rejoin DSBs.
Jeggo, Penny +2 more
core +1 more source
circRNA: A New Biomarker and Therapeutic Target for Esophageal Cancer
Biomedicines, 2022 Circular RNAs (circRNAs) comprise a large class of endogenous non-coding RNA with covalently closed loops and have independent functions as linear transcripts transcribed from identical genes. circRNAs are generated by a “back-splicing” process regulated
Katsutoshi Shoda +3 more
doaj +1 more source
DNA damage repair machinery and HIV escape from innate immune sensing
Frontiers in Microbiology, 2014 Viruses have been long known to perturb cell cycle regulators and key players of the DNA damage response to benefit their life cycles. In the case of the human immunodeficiency virus (HIV), the viral auxiliary protein Vpr activates the structure-specific
Christelle eBregnard +2 more
doaj +1 more source
Advanced Functional Materials, EarlyView.This study introduces VIVID (Vesicle In Vivo Identification using DNA), a qPCR‐based platform that tracks PCR‐amplifiable DNA tags loaded in the EVs for accurate and quantifiable EV biodistribution in vivo. ABSTRACT Extracellular vesicles (EVs) represent promising carriers for nucleic acid therapeutics, offering advantages over synthetic nanoparticles ...
Oscar Boyadjian +5 more
wiley +1 more source
Dissipatively Fueled Unidirectionally Communicating DNA Circuits That Control Biocatalysis. [PDF]
Angew Chem Int Ed EnglUnidirectionally communicating, out‐of‐equilibrium DNA circuits are used to control enzyme activity. Transient DNAzyme activation generates fuel for temporal trypsin activation. Cyclic fuel‐driven hybridization and exonuclease‐mediated reset enable precise control over lifetimes, which is analyzed using combined experimental and computational ...
Jung P +6 more
europepmc +3 more sources
Attacked from All Sides: RNA Decay in Antiviral Defense
Viruses, 2017 The innate immune system has evolved a number of sensors that recognize viral RNA (vRNA) to restrict infection, yet the full spectrum of host-encoded RNA binding proteins that target these foreign RNAs is still unknown.
Jerome M. Molleston, Sara Cherry
doaj +1 more source
Rex1p Deficiency Leads to Accumulation of Precursor Initiator tRNA\u3csup\u3eMet\u3c/sup\u3e and Polyadenylation of Substrate RNAs in \u3cem\u3eSaccharomyces cerevisiae\u3c/em\u3e [PDF]
, 2009 A synthetic genetic array was used to identify lethal and slow-growth phenotypes produced when a mutation in TRM6, which encodes a tRNA modification enzyme subunit, was combined with the deletion of any non-essential gene in Saccharomyces cerevisiae.
Anderson, James T. +5 more
core +1 more source
Advanced Materials Technologies, EarlyView.ABSTRACT Electrochemical biosensors enable the accurate and timely detection of clinical biomarkers, improving healthcare and precision medicine. MXene nanosheets, a class of 2D transition metal carbides, nitrides, and carbonitrides, are promising materials for developing next‐generation electrochemical biosensors due to their unique physicochemical ...
Muhsin Ali +4 more
wiley +1 more source
Biosensors, 2023 In this paper, we developed a sensitive, label-free and facile fluorescent strategy for detecting streptavidin (SA) based on double-hairpin DNA-templated copper nanoparticles (CuNPs) and terminal protection of small molecule-linked DNA. Herein, a special
Qiangsheng Xiao +5 more
doaj +1 more source
RAM function is dependent on Kapβ2-mediated nuclear entry [PDF]
, 2014 Eukaryotic gene expression is dependent on the modification of the first transcribed nucleotide of pre-mRNA by the addition of the 7-methylguanosine cap.
Aregger +24 more
core +4 more sources