Results 51 to 60 of about 2,910 (135)

The polyomaviruses WUPyV and KIPyV: a retrospective quantitative analysis in patients undergoing hematopoietic stem cell transplantation

Virology Journal, 2012
Background The polyomaviruses WUPyV and KIPyV have been detected in various sample types including feces indicating pathogenicity in the gastrointestinal (GI) system.
Motamedi Nasim, Mairhofer Helga, Nitschko Hans, Jäger Gundula, Koszinowski Ulrich H   +4 more
doaj   +1 more source

Unveiling Novel Viral Diversity, Biogeography, and Host Networks in Wildlife Through High‐Throughput Sequencing Data Mining

Advanced Science, Volume 12, Issue 46, December 11, 2025.
Analysis of 57 536 high‐throughput sequencing datasets uncovers a vast, hidden world of viruses in wildlife. The researchers reveal significant geographic and host‐specific patterns of viruses, and their surprising cross‐species transmissions, such as avian flu viruses infecting goats.
Hai Wang, Yafei Meng, Xiaoyuan Chen, Xinyuan Cui, Qian Zuo, Na Han, Xianghui Liang, Xuejuan Shen, Caiwu Li, Desheng Li, Fumin Wang, Liangping He, Rujian Chen, Xingbang Lu, Wenjie You, Aiping Wu, Rui‐Ai Chen, Wu Chen, Chan Ding, Yongyi Shen   +19 more
wiley   +1 more source

The Prognosis of Urothelial Carcinoma Between Kidney Transplantation Recipients and Normal Patients: A Propensity Score‐Matched Study

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Objective To evaluate the difference in the characteristics and prognosis between kidney transplantation (KT) recipients and normal patients with urothelial carcinoma. Method We retrospectively reviewed the characteristics of the kidney‐transplanted patients and the general patients who were diagnosed with urothelial carcinoma between 2013 and
Wu Taihao, Du Chunkai, Lyu Jingcheng, Zhu Yichen   +3 more
wiley   +1 more source

Secondary lymphoid tissue as an important site for WU polyomavirus infection in immunocompetent children

Journal of Medical Virology, 2011
AbstractThe polyomaviruses KI and WU (KIPyV and WUPyV) have been identified in respiratory specimens from children with acute respiratory infections, which suggests the respiratory tract as a possible site of infection. However, the persistence of infection in the lymphoid system is unknown.
COMAR, Manola, Zanotta N., Rossi T., Pelos G., D'AGARO, PIERLANFRANCO   +4 more
openaire   +3 more sources

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, Volume 58, Issue 11, November 2025.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Long‐Term Outcomes of BK Viremia in Kidney Transplant Recipients

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Background BK viremia is associated with worse kidney transplant function and de novo donor‐specific antibodies (DSA), but mortality and graft survival are not impacted in the short‐ and intermediate‐term. The long‐term impact of BK viremia remains unclear.
Srijan Tandukar, Qufei Wu, Sneha Chandrashekar, Divyash Shah, Chienhui Chiang, Kathryn Couch, Jennifer Trofe, Elizabeth M. Sonnenberg, Peter Abt, Mary Ann Lim, Vishnu Potluri, Roy Bloom   +11 more
wiley   +1 more source

Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor

MedComm, Volume 6, Issue 9, September 2025.
Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang, Huiqiang Wang, Shuo Wu, Ge Yang, Haiyan Yan, Lijun Qiao, Xingqiong Li, Mengyuan Wu, Jiandong Jiang, Yuhuan Li   +9 more
wiley   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Detection of WU polyomavirus DNA by real-time PCR in nasopharyngeal aspirates, serum, and stool samples. [PDF]

J Clin Virol, 2009
The human WU polyomavirus (WUPyV) has been recently described as a novel virus in respiratory tract samples.To investigate the viral load of WUPyV in nasopharyngeal aspirates (NPAs), stool, and serum samples of pediatric patients with acute respiratory tract diseases.We established a real-time PCR for WUPyV DNA and tested NPA obtained between 2002 and ...
Neske F, Blessing K, Pröttel A, Ullrich F, Kreth HW, Weissbrich B.   +5 more
europepmc   +3 more sources

Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System

Advanced Science, Volume 12, Issue 25, July 3, 2025.
This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao, Wanglu Li, Kaiyu He, Hongmei Wang, Yan Xu, Qun Wu, Liu Wang, Yao Nie   +7 more
wiley   +1 more source