Results 51 to 60 of about 2,615 (136)

The polyomaviruses WUPyV and KIPyV: a retrospective quantitative analysis in patients undergoing hematopoietic stem cell transplantation

Virology Journal, 2012
Background The polyomaviruses WUPyV and KIPyV have been detected in various sample types including feces indicating pathogenicity in the gastrointestinal (GI) system.
Motamedi Nasim, Mairhofer Helga, Nitschko Hans, Jäger Gundula, Koszinowski Ulrich H   +4 more
doaj   +1 more source

The Prognosis of Urothelial Carcinoma Between Kidney Transplantation Recipients and Normal Patients: A Propensity Score‐Matched Study

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Objective To evaluate the difference in the characteristics and prognosis between kidney transplantation (KT) recipients and normal patients with urothelial carcinoma. Method We retrospectively reviewed the characteristics of the kidney‐transplanted patients and the general patients who were diagnosed with urothelial carcinoma between 2013 and
Wu Taihao, Du Chunkai, Lyu Jingcheng, Zhu Yichen   +3 more
wiley   +1 more source

CRISPR Technology in Disease Management: An Updated Review of Clinical Translation and Therapeutic Potential

Cell Proliferation, Volume 58, Issue 11, November 2025.
CRISPR‐Cas systems offer transformative genome editing capabilities for precise manipulation of cellular genes. This enables two main therapeutic avenues: ex vivo modification of patient cells for re‐transplantation or direct in vivo gene targeting via advanced delivery methods.
Bahareh Farasati Far, Marziyeh Akbari, Mohammad Amin Habibi, Morteza Katavand, Sherko Nasseri   +4 more
wiley   +1 more source

Long‐Term Outcomes of BK Viremia in Kidney Transplant Recipients

Clinical Transplantation, Volume 39, Issue 10, October 2025.
ABSTRACT Background BK viremia is associated with worse kidney transplant function and de novo donor‐specific antibodies (DSA), but mortality and graft survival are not impacted in the short‐ and intermediate‐term. The long‐term impact of BK viremia remains unclear.
Srijan Tandukar, Qufei Wu, Sneha Chandrashekar, Divyash Shah, Chienhui Chiang, Kathryn Couch, Jennifer Trofe, Elizabeth M. Sonnenberg, Peter Abt, Mary Ann Lim, Vishnu Potluri, Roy Bloom   +11 more
wiley   +1 more source

Secondary lymphoid tissue as an important site for WU polyomavirus infection in immunocompetent children

Journal of Medical Virology, 2011
AbstractThe polyomaviruses KI and WU (KIPyV and WUPyV) have been identified in respiratory specimens from children with acute respiratory infections, which suggests the respiratory tract as a possible site of infection. However, the persistence of infection in the lymphoid system is unknown.
COMAR, Manola, Zanotta N., Rossi T., Pelos G., D'AGARO, PIERLANFRANCO   +4 more
openaire   +3 more sources

Disruption of Spike Priming in Virus Entry: Tetrandrine as a Pan‐Coronavirus Inhibitor

MedComm, Volume 6, Issue 9, September 2025.
Tetrandrine inhibits the infection of HCoV‐OC43, HCoV‐229E, SARS‐CoV‐2, and its major variants by blocking virus entry. Specifically, tetrandrine breaks the interaction between TMPRSS2 and Spike, therefore suppress its priming and the following membrane fusion, and induces Spike to degradation.
Kun Wang, Huiqiang Wang, Shuo Wu, Ge Yang, Haiyan Yan, Lijun Qiao, Xingqiong Li, Mengyuan Wu, Jiandong Jiang, Yuhuan Li   +9 more
wiley   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, Volume 12, Issue 32, August 28, 2025.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System

Advanced Science, Volume 12, Issue 25, July 3, 2025.
This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao, Wanglu Li, Kaiyu He, Hongmei Wang, Yan Xu, Qun Wu, Liu Wang, Yao Nie   +7 more
wiley   +1 more source

Impact of Psychological Stress and Spontaneous Tumour Regression on the Hippocampal Proteome in a Mouse Model of Breast Cancer

Journal of Neurochemistry, Volume 169, Issue 4, April 2025.
This study examines how breast cancer and psychological stress impact the hippocampal proteome, uncovering altered signalling pathways linked to mitochondrial dysfunction, impaired energy production, and altered synaptic plasticity; that is, cellular processes that are critical for memory formation and cognitive health.
Myrthe Mampay, Gheed Al‐Hity, Sara O. Rolle, Walla Alzboon, Nicolas A. Stewart, Melanie S. Flint, Graham K. Sheridan   +6 more
wiley   +1 more source

Expression of toll‐like receptors in recurrent pleomorphic adenoma and carcinoma ex pleomorphic adenoma

APMIS, Volume 133, Issue 1, January 2025.
Pleomorphic adenoma (PA) is a benign salivary gland tumour that may recur or undergo malignant transformation (CXPA). Toll‐like receptors (TLR) mediate immune responses triggered by various agents such as viruses and are related to tumour formation either by stimulating or suppressing their growth, with variation across different tumour entities.
Maria K. Jauhiainen, Anttoni Markkanen, Timo Atula, Katri Aro, Caj Haglund, Maria Söderlund‐Venermo, Antti A. Mäkitie, Saku T. Sinkkonen, Jaana Hagström   +8 more
wiley   +1 more source