Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field [PDF]
Viruses, 2023 Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its
Ugo Moens +4 more
doaj +4 more sources
Serology Identifies LIPyV as a Feline Rather than a Human Polyomavirus [PDF]
Viruses, 2023 The number of identified human polyomaviruses (HPyVs) has increased steadily over the last decade. Some of the novel HPyVs have been shown to cause disease in immunocompromised individuals.
Sergio Kamminga +4 more
doaj +4 more sources
Age-specific seroprevalence of human polyomavirus 12 and Saint Louis and New Jersey polyomaviruses [PDF]
Emerging Microbes and Infections, 2018 The presence of specific antibodies against human polyomavirus 12, Saint Louis polyomavirus and New Jersey polyomavirus was investigated by using virus-like particle-based ELISAs with serum samples from 706 Italians aged 1- to 100-years-old. The findings
Pauline Gaboriaud +9 more
doaj +2 more sources
The Human Polyomavirus Middle and Alternative T-Antigens; Thoughts on Roles and Relevance to Cancer [PDF]
Frontiers in Microbiology, 2018 Approximately 15–20% of human cancer is related to infection, which renders them potentially preventable by antimicrobial or antiviral therapy. Human polyomaviruses (PyVs) are relevant in this regard, as illustrated by the involvement of Merkel cell ...
Els van der Meijden, Mariet Feltkamp
doaj +2 more sources
Viruses, 2021 Merkel cell polyomavirus (MCPyV) is a human polyomavirus causally linked to the development of Merkel cell carcinoma (MCC), an aggressive malignancy that largely arises within the dermis of the skin.
Amanda S. W. Loke +3 more
doaj +3 more sources
The Role of Merkel Cell Polyomavirus and Other Human Polyomaviruses in Emerging Hallmarks of Cancer
Viruses, 2015 Polyomaviruses are non-enveloped, dsDNA viruses that are common in mammals, including humans. All polyomaviruses encode the large T-antigen and small t-antigen proteins that share conserved functional domains, comprising binding motifs for the tumor ...
Ugo Moens +3 more
doaj +3 more sources
Human polyomavirus BKV infection of endothelial cells results in interferon pathway induction and persistence. [PDF]
PLoS Pathogens, 2019 Polyomavirus BKV is highly prevalent among humans. The virus establishes an asymptomatic persistent infection in the urinary system in healthy people, but uncontrolled productive infection of the virus in immunocompromised patients can lead to serious ...
Ping An +4 more
doaj +2 more sources
Prevalence and Molecular Profiling of Merkel Cell Polyomavirus in Patients With Monkeypox Virus Infection. [PDF]
J Med VirolABSTRACT Mpox, caused by Monkeypox virus (MPXV), is associated with mucosal involvement and immune modulation that may influence viral coinfections. Merkel Cell Polyomavirus (MCPyV), a ubiquitous virus capable of lifelong persistence, was investigated in 66 Mpox patients enrolled at Lazzaro Spallanzani National Institute for Infectious Diseases (Rome ...
Passerini S +8 more
europepmc +2 more sources
Merkel cell polyomavirus exploits extracellular vesicles for skin infection and host immune evasion through activated Wnt signaling. [PDF]
PLoS PathogensResearch on small DNA tumor viruses has been limited by the lack of advanced virus culture systems that support robust viral infection. Thus, studies involving Merkel cell polyomavirus (MCPyV), a human oncogenic polyomavirus, primarily rely on model ...
Alexander M Pham +4 more
doaj +2 more sources
The Structure of an Infectious Human Polyomavirus and Its Interactions with Cellular Receptors. [PDF]
Structure, 2018 Hurdiss DL +4 more
europepmc +2 more sources