Phosphorylation of Human Polyomavirus Large and Small T Antigens: An Ignored Research Field [PDF]
Viruses, 2023 Protein phosphorylation and dephosphorylation are the most common post-translational modifications mediated by protein kinases and protein phosphatases, respectively. These reversible processes can modulate the function of the target protein, such as its
Ugo Moens +4 more
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Serology Identifies LIPyV as a Feline Rather than a Human Polyomavirus [PDF]
Viruses, 2023 The number of identified human polyomaviruses (HPyVs) has increased steadily over the last decade. Some of the novel HPyVs have been shown to cause disease in immunocompromised individuals.
Sergio Kamminga +4 more
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Age-specific seroprevalence of human polyomavirus 12 and Saint Louis and New Jersey polyomaviruses [PDF]
Emerging Microbes and Infections, 2018 The presence of specific antibodies against human polyomavirus 12, Saint Louis polyomavirus and New Jersey polyomavirus was investigated by using virus-like particle-based ELISAs with serum samples from 706 Italians aged 1- to 100-years-old. The findings
Pauline Gaboriaud +9 more
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Glucocorticoids Do Not Enhance BK Polyomavirus Replication in Human Renal Proximal Tubular Epithelial Cells In Vitro. [PDF]
Clin Transl SciABSTRACT BK polyomavirus (BKPyV) infection may lead to BKPyV‐associated nephropathy (BKPyVAN) and subsequent graft loss in kidney transplant recipients. Experimental studies have suggested that glucocorticoids (GCs) may enhance BKPyV replication through a steroid‐responsive element within the viral genome.
Moest WT +7 more
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The Human Polyomavirus Middle and Alternative T-Antigens; Thoughts on Roles and Relevance to Cancer [PDF]
Frontiers in Microbiology, 2018 Approximately 15–20% of human cancer is related to infection, which renders them potentially preventable by antimicrobial or antiviral therapy. Human polyomaviruses (PyVs) are relevant in this regard, as illustrated by the involvement of Merkel cell ...
Els van der Meijden, Mariet Feltkamp
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Viruses, 2021 Merkel cell polyomavirus (MCPyV) is a human polyomavirus causally linked to the development of Merkel cell carcinoma (MCC), an aggressive malignancy that largely arises within the dermis of the skin.
Amanda S. W. Loke +3 more
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Polyomavirus Drives Cerebellar Lesions in AIDS Monkeys With Ataxia. [PDF]
MedComm (2020)Chronic SIV‐infected macaques with ataxia develop severe cerebellar lesions driven by simian polyomavirus 40 (SV40) infection. SV40 preferentially infects cerebellar granule cells, inducing pyroptosis and an aberrant proliferative state. Pyroptotic neuronal injury promotes microglial recruitment and activation, amplifying local neuroinflammation and ...
Song TZ +9 more
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Human polyomavirus BKV infection of endothelial cells results in interferon pathway induction and persistence. [PDF]
PLoS Pathogens, 2019 Polyomavirus BKV is highly prevalent among humans. The virus establishes an asymptomatic persistent infection in the urinary system in healthy people, but uncontrolled productive infection of the virus in immunocompromised patients can lead to serious ...
Ping An +4 more
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Sirolimus and Other Mechanistic Target of Rapamycin Inhibitors Directly Activate Latent Pathogenic Human Polyomavirus Replication. [PDF]
J Infect Dis, 2021 Alvarez Orellana J +4 more
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The Structure of an Infectious Human Polyomavirus and Its Interactions with Cellular Receptors. [PDF]
Structure, 2018 Hurdiss DL +4 more
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