Regulation of Polyomavirus Transcription by Viral and Cellular Factors
Viruses, 2020 Polyomavirus infection is widespread in the human population. This family of viruses normally maintains latent infection within the host cell but can cause a range of human pathologies, especially in immunocompromised individuals.
June F. Yang, Jianxin You
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Structural Basis and Evolution of Glycan Receptor Specificities within the Polyomavirus Family
mBio, 2020 Asymptomatic infections with polyomaviruses in humans are common, but these small viruses can cause severe diseases in immunocompromised hosts. New Jersey polyomavirus (NJPyV) was identified via a muscle biopsy in an organ transplant recipient with ...
Luisa J. Ströh +8 more
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Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection
Viruses, 2020 Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating ...
Paul Clark +6 more
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Polyomavirus Wakes Up and Chooses Neurovirulence
Viruses, 2023 JC polyomavirus (JCPyV) is a human-specific polyomavirus that establishes a silent lifelong infection in multiple peripheral organs, predominantly those of the urinary tract, of immunocompetent individuals.
Arrienne B. Butic +3 more
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In Vitro and In Vivo Models for the Study of Human Polyomavirus Infection. [PDF]
Viruses, 2016 Barth H +5 more
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Serological cross-reactivity between Merkel cell polyomavirus and two closely related chimpanzee polyomaviruses. [PDF]
PLoS ONE, 2014 Phylogenetic analyses based on the major capsid protein sequence indicate that Merkel cell polyomavirus (MCPyV) and chimpanzee polyomaviruses (PtvPyV1, PtvPyV2), and similarly Trichodysplasia spinulosa-associated polyomavirus (TSPyV) and the orangutan ...
Jérôme T J Nicol +6 more
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The Agnogene of the Human Polyomavirus BK Is Expressed [PDF]
Journal of Virology, 1998 ABSTRACT Primate polyomavirus genomes all contain an open reading frame at the 5′ end of the late coding region called the agnogene. A simian virus 40 agnoprotein with unknown functions has previously been demonstrated. We now show that a BK virus agnoprotein appears in the perinuclear area and cytoplasm late in the infectious cycle.
C H, Rinaldo, T, Traavik, A, Hey
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Clinical and Epidemiologic Characterization of WU Polyomavirus Infection, St. Louis, Missouri
Emerging Infectious Diseases, 2007 WU polyomavirus is a recently described polyomavirus found in patients with respiratory infections. Of 2,637 respiratory samples tested in St. Louis, Missouri, 2.7% were positive for WU polyomavirus by PCR, and 71% were coinfected with other respiratory ...
Binh-Minh Le +8 more
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Taking the Scenic Route: Polyomaviruses Utilize Multiple Pathways to Reach the Same Destination
Viruses, 2020 Members of the Polyomaviridae family differ in their host range, pathogenesis, and disease severity. To date, some of the most studied polyomaviruses include human JC, BK, and Merkel cell polyomavirus and non-human subspecies murine and simian virus 40 ...
Colleen L. Mayberry, Melissa S. Maginnis
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Human polyomavirus JC virus genome [PDF]
Journal of Virology, 1984 The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. The amino acid sequence of six proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2, and VP3; and the agnogene product encoded within the late leader sequence ...
R J, Frisque, G L, Bream, M T, Cannella
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