Results 1 to 10 of about 946 (107)

Therapeutic potential of flavonols in the treatment of JCPyV [PDF]

Microbiology Spectrum
JC polyomavirus (JCPyV) is a double-stranded DNA virus that causes progressive multifocal leukoencephalopathy (PML), a demyelinating disease with a high rate of morbidity and mortality. There are limited treatment options for patients diagnosed with PML,
Walter Atwood, Bethany O'Hara, Sheila Haley   +2 more
exaly   +4 more sources

Discriminating between JCPyV and BKPyV in Urinary Virome Data Sets

Viruses, 2021
Polyomaviruses are abundant in the human body. The polyomaviruses JC virus (JCPyV) and BK virus (BKPyV) are common viruses in the human urinary tract.
Catherine Putonti, Alan Wolfe, Mormando Rita   +2 more
exaly   +3 more sources

JCPyV miR-J1-5p in Urine of Natalizumab-Treated Multiple Sclerosis Patients

Viruses, 2021
The use of Natalizumab in Multiple Sclerosis (MS) can cause the reactivation of the polyomavirus JC (JCPyV); this may result in the development of progressive multifocal leukoencephalopathy (PML), a rare and usually lethal disease.
Mario Clerici, Roberta Mancuso, Simone Agostini   +2 more
exaly   +3 more sources

COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains

Viruses, 2022
Since the non-coding control region (NCCR) and microRNA (miRNA) could represent two different and independent modalities of regulating JC polyomavirus (JCPyV) replication at the transcriptional and post-transcriptional levels, the interplay between JC ...
Valeria Pietropaolo, Anna TERESA Palamara, Ugo Moens   +2 more
exaly   +3 more sources

Co-Detection of EBV and Human Polyomavirus JCPyV in a Case of AIDS-Related Multifocal Primary Central Nervous System Diffuse Large B-Cell Lymphoma

Viruses, 2023
The human neurotropic Polyomavirus JCPyV is the widespread opportunistic causative pathogen of the fatal demyelinating disease progressive multifocal leukoencephalopathy; however, it has also been implicated in the oncogenesis of several types of cancers.
Luis Del Valle, Del Valle Luis
exaly   +3 more sources

Performance of Ultrasensitive Polymerase Chain Reaction Testing for JC Polyomavirus in Cerebrospinal Fluid Compared with Pathological Diagnosis of Progressive Multifocal Leukoencephalopathy [PDF]

Viruses
Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease caused by the JC polyomavirus (JCPyV). Based on the clinical criteria, PML is diagnosed via polymerase chain reaction (PCR) detection of JCPyV DNA in cerebrospinal fluid (CSF) in
Kenta Takahashi, Kazuo Nakamichi, Yuko Sato, Harutaka Katano, Hideki Hasegawa, Masayuki Saijo, Tadaki Suzuki   +6 more
doaj   +2 more sources

Human Polyomavirus JCPyV and Its Role in Progressive Multifocal Leukoencephalopathy and Oncogenesis

Frontiers in Oncology, 2019
The human neurotropic virus JCPyV, a member of the Polyomaviridiae family, is the opportunistic infectious agent of Progressive Multifocal Leukoencephalopathy (PML), a fatal disease seen in severe immunosuppressive conditions and, during the last decade,
Sérgio Pina Oviedo, Luis Del Valle, Del Valle Luis   +2 more
exaly   +3 more sources

Clinical and molecular analysis of JCPyV and BKPyV infection and associated risk of urothelial carcinoma development in the upper tract [PDF]

Virology Journal
Background Human polyomaviruses (HPyVs), JC polyomavirus (JCPyV) and BK polyomavirus (BKPyV), have been found in upper tract urothelial carcinoma UTUC; however, the association of the viral oncogenic factors and clinical characteristics of UTUC remains ...
Chun-Nun Chao, Chi-Feng Hung, Wei‑Hong Lai, Chun-Liang Tung, Wan-Yun Yeh, Kai-Wu Yang, Meilin Wang, Ya-Yan Lai, Pei-Lain Chen, Cheng-Huang Shen   +9 more
doaj   +2 more sources

Alterations of the miR-126-3p/POU2AF1/Spi-B Axis and JCPyV Reactivation in Multiple Sclerosis Patients Receiving Natalizumab

Frontiers in Neurology, 2022
Natalizumab (NTZ) can reactivate human polyomavirus John Cunningham polyomavirus (JCPyV) latent infection and lead to progressive multifocal leukoencephalopathy (PML). NTZ modulates the expression of microRNA-126-3p (miR-126-3p) and its target genes, Spi-
Mario Clerici, Hernis Ambra, Roberta Mancuso   +2 more
exaly   +3 more sources

Identification of JC polyomavirus in upper respiratory samples from Portuguese children [PDF]

Heliyon
Background: JC polyomavirus (JCPyV) is ubiquitous in the human population and the causative agent of a rare, fatal and demyelinating disease of the central nervous system named Progressive Multifocal Leukoencephalopathy (PML).
Joana M. Oliveira, Daniela Veiga, Helena Martins, Cristina Luxo, Ana M. Matos   +4 more
doaj   +2 more sources