Results 41 to 50 of about 1,015 (152)

Prevalence of JC Polyomavirus in Patients with Neuroinvasive Disease of Unknown Etiology in Croatia

Medicina, 2023
Background and Objectives: John Cunningham polyomavirus (JCPyV) is a highly prevalent virus in the human population. The prevalence of JCPyV in patients with central nervous system disorders has not been examined extensively. The aim of this study was to
Tatjana Vilibic-Cavlek, Maja Bogdanic, Tajana Peric, Leona Radmanic, Ljiljana Antolasic, Ljiljana Milasincic, Snjezana Zidovec-Lepej   +6 more
doaj   +1 more source

High anti-JCPyV serum titers coincide with high CSF cell counts in RRMS patients [PDF]

Multiple Sclerosis Journal, 2020
Background: Progressive multifocal leukoencephalopathy (PML) can in rare cases occur in natalizumab-treated patients with high serum anti-JCPyV antibodies, hypothetically due to excessive blockade of immune cell migration.
Tilman Schneider-Hohendorf, Andreas Schulte-Mecklenbeck, Patrick Ostkamp, Claudia Janoschka, Marc Pawlitzki, Felix Luessi, Frauke Zipp, Sven G Meuth, Luisa Klotz, Heinz Wiendl, Catharina C Gross, Nicholas Schwab   +11 more
openaire   +2 more sources

Biogenesis of JC polyomavirus associated extracellular vesicles

Journal of Extracellular Biology, 2022
JC polyomavirus (JCPyV) is a small, non‐enveloped virus that persists in the kidney in about half the adult population. In severely immune‐compromised individuals JCPyV causes the neurodegenerative disease progressive multifocal leukoencephalopathy (PML)
Jenna Morris‐Love, Bethany A. O'Hara, Gretchen V. Gee, Aisling S. Dugan, Ryan S. O'Rourke, Brandon E. Armstead, Benedetta Assetta, Sheila A. Haley, Walter J. Atwood   +8 more
doaj   +1 more source

High expression of JC polyomavirus-encoded microRNAs in progressive multifocal leukoencephalopathy tissues and its repressive role in virus replication.

PLoS Pathogens, 2020
JC polyomavirus (JCPyV, JCV) causes progressive multifocal leukoencephalopathy (PML) in immunocompromised hosts. JCPyV replicates in oligodendrocytes within the brain tissue of patients with PML.
Kenta Takahashi, Yuko Sato, Tsuyoshi Sekizuka, Makoto Kuroda, Tadaki Suzuki, Hideki Hasegawa, Harutaka Katano   +6 more
doaj   +1 more source

IgG Seroreactivites to Viral Capsid Protein VP1 of JC and BK Polyomaviruses in Children at Early Ages with Special Reference to Parental Cofactors

Children, 2023
BK (BKPyV) and JC (JCPyV) polyomaviruses are widespread in humans. Transmission at an early age and the role of parents in spreading these viruses through the family are incompletely understood.
Hanna K. Laine, Tim Waterboer, Kari Syrjänen, Seija Grenman, Karolina Louvanto, Stina Syrjänen   +5 more
doaj   +1 more source

Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9 [PDF]

Scientific Reports, 2016
AbstractProgressive multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligodendrocytes by the JC polyomavirus (JCPyV). Currently, there is no anti-viral therapeutic available against JCPyV infection. The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system ...
Chou, Yi-Ying, Krupp, Annabel, Kaynor, Campbell, Gaudin, Raphael, Ma, Minghe, Cahir-Mcfarland, Ellen, Kirchhausen, Tom   +6 more
openaire   +5 more sources

Fifty Years of JC Polyomavirus: A Brief Overview and Remaining Questions

Viruses, 2020
In the fifty years since the discovery of JC polyomavirus (JCPyV), the body of research representing our collective knowledge on this virus has grown substantially.
Abigail L. Atkinson, Walter J. Atwood
doaj   +1 more source

Risk Assessment of Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis Patients during 1 Year of Ocrelizumab Treatment

Viruses, 2021
Background: Progressive multifocal leukoencephalopathy (PML) caused by the JC virus is the main limitation to the use of disease modifying therapies for treatment of multiple sclerosis (MS). Methods: To assess the PML risk in course of ocrelizumab, urine
Carla Prezioso, Alfonso Grimaldi, Doriana Landi, Carolina Gabri Nicoletti, Gabriele Brazzini, Francesca Piacentini, Sara Passerini, Dolores Limongi, Marco Ciotti, Anna Teresa Palamara, Girolama Alessandra Marfia, Valeria Pietropaolo   +11 more
doaj   +1 more source

Antibody escape by polyomavirus capsid mutation facilitates neurovirulence

eLife, 2020
JCPyV polyomavirus, a member of the human virome, causes progressive multifocal leukoencephalopathy (PML), an oft-fatal demyelinating brain disease in individuals receiving immunomodulatory therapies. Mutations in the major viral capsid protein, VP1, are
Matthew D Lauver, Daniel J Goetschius, Colleen S Netherby-Winslow, Katelyn N Ayers, Ge Jin, Daniel G Haas, Elizabeth L Frost, Sung Hyun Cho, Carol M Bator, Stephanie M Bywaters, Neil D Christensen, Susan L Hafenstein, Aron E Lukacher   +12 more
doaj   +1 more source

Dynamics and Patterning of 5-Hydroxytryptamine 2 Subtype Receptors in JC Polyomavirus Entry

Viruses, 2022
The organization and dynamics of plasma membrane receptors are a critical link in virus-receptor interactions, which finetune signaling efficiency and determine cellular responses during infection. Characterizing the mechanisms responsible for the active
Kashif Mehmood, Michael P. Wilczek, Jeanne K. DuShane, Matthew T. Parent, Colleen L. Mayberry, Jaqulin N. Wallace, Francois L. Levasseur, Tristan M. Fong, Samuel T. Hess, Melissa S. Maginnis   +9 more
doaj   +1 more source