Results 61 to 70 of about 1,015 (152)

Gene Therapy for Human Lung Adenocarcinoma Using a Suicide Gene Driven by a Lung-Specific Promoter Delivered by JC Virus-Like Particles. [PDF]

PLoS ONE, 2016
Lung adenocarcinoma, the most commonly diagnosed type of lung cancer, has a poor prognosis even with combined surgery, chemotherapy, or molecular targeted therapies.
Chun-Nun Chao, Mien-Chun Lin, Chiung-Yao Fang, Pei-Lain Chen, Deching Chang, Cheng-Huang Shen, Meilin Wang   +6 more
doaj   +1 more source

Artificial Intelligence‐Driven Proteomics Identifies Plasma Protein Signatures for Diagnosis and Stratification of Behçet's Disease

Advanced Science, Volume 12, Issue 35, September 18, 2025.
Molecular and functional landscape of BD progression and severity based on in‐depth proteomics. Tree boosting machine learning models with favorable performance in BD diagnosis and stratification. Efficient biomarker panels for BD diagnosis and stratification.
Linlin Cheng, Mansheng Li, Zhou Bai, Xiaobo Yu, Wenjie Zheng, Yongzhe Li, Yudong Liu   +6 more
wiley   +1 more source

Sequence analysis of the non-coding control region of John Cunningham virus isolates from patients with multiple sclerosis treated with natalizumab

Журнал микробиологии, эпидемиологии и иммунобиологии, 2023
Introduction. The John Cunningham virus (JCPyV) causes a fatal demyelinating disease of the central nervous system known as progressive multifocal leukoencephalopathy (PML). In healthy people, the JCPyV non-coding control region (NCCR) is not rearranged,
Marina A. Tyumentseva, Aleksandr I. Tyumentsev, Maria N. Zakharova, Lola S. Askarova, Taras O. Simaniv, Mikhail A. Piradov, Vasily G. Akimkin   +6 more
doaj   +1 more source

Torque teno virus as a marker of immune status in immunocompromised patients: A systematic review

European Journal of Clinical Investigation, Volume 55, Issue 8, August 2025.
Abstract Background Torque teno virus (TTV) is not known to cause disease in humans; however, chronic inflammatory conditions and immunosuppression states can favour TTV replication. This study aimed to verify the effectiveness of TTV as an immune biomarker.
Janaina B. Medina, Fábio França Vieira e Silva, Rafael Antônio Velôso Caixeta, Bruna de Oliveira Rech, Alba Perez‐Jardón, María Elena Padín‐Iruegas, Mario Pérez‐Sayáns, Paulo Henrique Braz‐Silva, Karem L. Ortega   +8 more
wiley   +1 more source

The potential of long‐term wastewater‐based surveillance to predict COVID‐19 waves peak in Mexico

Water Environment Research, Volume 97, Issue 5, May 2025.
Wastewater‐based surveillance (WBS) predicted COVID‐19 wave onsets with varying lead times influenced by SARS‐CoV‐2 variants. Delta and Omicron waves showed lead times of 5–14 and 1–4 days, respectively. WBS aligned with case reports but overestimated peaks due to variant transmissibility, highlighting its potential and limitations in public health ...
Marcela Zavala‐Méndez, Andrés Sánchez‐Pájaro, Astrid Schilmann, Juliana Calábria de Araújo, Germán Buitrón, Julián Carrillo‐Reyes   +5 more
wiley   +1 more source

Current Perspectives on JC Polyomavirus Transmission and Associated Diseases: Implications for Prevention in Risk Populations

Viruses
JC polyomavirus (JCPyV) is a worldwide-distributed human virus. Primary infection with JCPyV is usually asymptomatic and followed by a lifelong persistent infection.
Joana M Oliveira, Cristina Luxo, Ana Ana M Matos   +2 more
doaj   +1 more source

Multiple DNA Viruses and HPV Integration in Inverted Papilloma and Associated Sinonasal Carcinoma

The Laryngoscope, Volume 135, Issue 2, Page 677-686, February 2025.
HPV6 integration was observed in benign inverted papilloma, whereas HPV16 is present pre‐ and post‐malignant transformation. Marked increase in viral diversity was present, supported by accumulation of mutations over time. Objectives Sinonasal inverted papilloma (IP) has a locally destructive growth pattern, can relapse, and can undergo malignant ...
Maria K. Jauhiainen, Lari Pyöriä, Sanna Viitasalo, Ushanandini Mohanraj, Leena‐Maija Aaltonen, Maria Söderlund‐Venermo, Jaana Hagström, Antti A. Mäkitie, Maria F. Perdomo, Saku T. Sinkkonen   +9 more
wiley   +1 more source

The Oxindole GW-5074 Inhibits JC Polyomavirus Infection and Spread by Antagonizing the MAPK-ERK Signaling Pathway

mBio, 2023
JC polyomavirus (JCPyV) is a ubiquitous, double-stranded DNA virus that causes the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML) in immunocompromised patients. Current treatments for PML are limited to immune reconstitution,
Jacob Kaiserman, Bethany A. O’Hara, Kaitlin Garabian, Avraham Lukacher, Sheila A. Haley, Walter J. Atwood   +5 more
doaj   +1 more source

Highly restrictive and directional penetration of the blood cerebral spinal fluid barrier by JCPyV. [PDF]

PLoS Pathog
The human polyomavirus JCPyV is an opportunistic pathogen that infects greater than 60% of the world’s population. The virus establishes a persistent and asymptomatic infection in the urogenital system but can cause a fatal demyelinating disease in immunosuppressed or immunomodulated patients following invasion of the CNS.
O'Hara BA, Lukacher AS, Garabian K, Kaiserman J, MacLure E, Ishikawa H, Schroten H, Haley SA, Atwood WJ.   +8 more
europepmc   +4 more sources

Extracellular vesicles promote the infection and pathogenicity of Japanese encephalitis virus

Journal of Extracellular Vesicles, Volume 14, Issue 1, January 2025.
Abstract Japanese encephalitis virus (JEV) is a neurotropic zoonotic pathogen that poses a serious threat to public health. Currently, there is no specific therapeutic agent available for JEV infection, primarily due to the complexity of its infection mechanism and pathogenesis.
Junyao Xiong, Ling'en Yang, Xiaowei Nan, Shuo Zhu, Mengxue Yan, Shengxian Xiang, Luping Zhang, Qi Li, Chengjie Yang, Xugang Wang, Ning Wei, Huanchun Chen, Youhui Si, Shengbo Cao, Jing Ye   +14 more
wiley   +1 more source