Results 81 to 90 of about 1,015 (152)

Concurrent JCPyV-DNAemia Is Correlated With Poor Graft Outcome in Kidney Transplant Recipients With Polyomavirus-associated Nephropathy. [PDF]

Transplantation
Background. Co-infection of JC polyomavirus (JCPyV) and BK polyomavirus (BKPyV) is uncommon in kidney transplant recipients, and the prognosis is unclear. This study aimed to investigate the effect of concurrent JCPyV-DNAemia on graft outcomes in BKPyV-infected kidney transplant recipients with polyomavirus-associated ...
Zhang H, Luo JQ, Zhao GD, Huang Y, Yang SC, Chen PS, Li J, Wu CL, Qiu J, Chen XT, Huang G.   +10 more
europepmc   +3 more sources

Molecular epidemiology and risk factors associated with BK and JC polyomavirus urinary shedding after kidney allograft

Journal of Medical Virology, Volume 96, Issue 6, June 2024.
Abstract Polyomaviruses BK (BKPyV) and JC (JCPyV), belonging to the Polyomaviridae, are responsible for human pathologies. In kidney transplant recipients, BKPyV replication can lead to irreversible nephron damage whereas JCPyV replication remains asymptomatic.
Baptiste Demey, Aurélien Aubry, Véronique Descamps, Virginie Morel, My Hanh Hillary Le, Claire Presne, François Brazier, François Helle, Etienne Brochot   +8 more
wiley   +1 more source

A functional and structural comparative analysis of large tumor antigens reveals evolution of different importin α‐dependent nuclear localization signals

Protein Science, Volume 33, Issue 2, February 2024.
Abstract Nucleocytoplasmic transport regulates the passage of proteins between the nucleus and cytoplasm. In the best characterized pathway, importin (IMP) α bridges cargoes bearing basic, classical nuclear localization signals (cNLSs) to IMPβ1, which mediates transport through the nuclear pore complex.
Emily M. Cross, Nasim Akbari, Hanieh Ghassabian, Mikayla Hoad, Silvia Pavan, Daryl Ariawan, Camilla M. Donnelly, Enrico Lavezzo, Gayle F. Petersen, Jade K. Forwood, Gualtiero Alvisi   +10 more
wiley   +1 more source

A Retrograde Trafficking Inhibitor of Ricin and Shiga-Like Toxins Inhibits Infection of Cells by Human and Monkey Polyomaviruses

mBio, 2013
Polyomaviruses are ubiquitous pathogens that cause severe disease in immunocompromised individuals. JC polyomavirus (JCPyV) is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML), whereas BK ...
Christian D. S. Nelson, Dan W. Carney, Aaron Derdowski, Alex Lipovsky, Gretchen V. Gee, Bethany O’Hara, Paul Williard, Daniel DiMaio, Jason K. Sello, Walter J. Atwood   +9 more
doaj   +1 more source

Progressive Multifocal Leukoencephalopathy-Associated Mutations in the JC Polyomavirus Capsid Disrupt Lactoseries Tetrasaccharide c Binding

mBio, 2013
The human JC polyomavirus (JCPyV) is the causative agent of the fatal, demyelinating disease progressive multifocal leukoencephalopathy (PML). The Mad-1 prototype strain of JCPyV uses the glycan lactoseries tetrasaccharide c (LSTc) and serotonin receptor
Melissa S. Maginnis, Luisa J. Ströh, Gretchen V. Gee, Bethany A. O’Hara, Aaron Derdowski, Thilo Stehle, Walter J. Atwood   +6 more
doaj   +1 more source

High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection

Antiviral Research
JC polyomavirus (JCPyV) is a nonenveloped, double-stranded DNA virus that infects the majority of the population. Immunocompetent individuals harbor infection in their kidneys, while severe immunosuppression can result in JCPyV spread to the brain, causing the neurodegenerative disease progressive multifocal leukoencephalopathy (PML).
Avery C.S. Bond, Mason A. Crocker, Michael P. Wilczek, Jeanne K. DuShane, Amanda L. Sandberg, Lucas J. Bennett, Nicholas R. Leclerc, Melissa S. Maginnis   +7 more
openaire   +2 more sources

Progressive multifocal leukoencephalopathy in HIV-infected patients: clinical features and diagnosis (literature review)

Журнал инфектологии, 2019
Progressive multifocal leukoencephalopathy (PML) is one of the most severe opportunistic diseases of the central nervous system, which leads to multiple demyelination of brain structures, neurological symptoms and frequent death or disability of the ...
E. A. Samotolkina, A. V. Pokrovskaya, S. V. Matosova, E. A. Domonova   +3 more
doaj   +1 more source

JCPyV Infection is Highly Prevalent in UTUC: Implications for Oncogenic Factors and Pathological Staging

Abstract Background Upper tract urothelial carcinoma (UTUC) is a subtype of urothelial carcinoma that shares similarities with bladder cancer but is more aggressive. Human polyomaviruses (HPyVs) have been found in UTUC; however, the association of the viral large T antigen (LT) protein and the tumor suppressor protein, p53, post-infection with
Chun‐Nun Chao, Chi-Feng Hung, Wei‑Hong Lai, Chun-Liang Tung, Wan-Yun Yeh, Kai-Wu Yang, Meilin Wang, Ya-Yan Lai, Pei-Lain Chen, Cheng-Huang Shen   +9 more
openaire   +1 more source

John Cunningham Virus and Progressive Multifocal Leukoencephalopathy: A Falsely Played Diagnosis

Diseases
Progressive Multifocal Leukoencephalopathy (PML) is a possibly fatal demyelinating disease and John Cunningham Polyomavirus (JCPyV) is believed to cause this condition.
Dimitra S. Mouliou
doaj   +1 more source

Nested PCR detection of JC polyomavirus large T-antigen in prostate cancer tissues: a case–control analysis in a Sudanese population

Journal of the Egyptian National Cancer Institute
Background The potential involvement of JC polyomavirus (JCPyV) in prostate cancer (PCa) remains a subject of debate, as existing in vitro studies have produced conflicting results.
Maria Ahmed Mohamed Higair, Babbiker Mohammed Taher Gorish, Sana Eltahir Abdallah   +2 more
doaj   +1 more source