Results 91 to 100 of about 1,462 (171)

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier, Viktoria M. S. Kjær, Stephen Griffin, Birthe B. Kragelund, Mette M. Rosenkilde   +4 more
wiley   +1 more source

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source

High rates of anal Merkel Cell Polyomavirus and HPV co‐infection among people living with HIV

Journal of Medical Virology, Volume 96, Issue 8, August 2024.
Abstract Knowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens from 150 individuals of both sexes were analyzed for screening purposes.
Sara Passerini, Matteo Fracella, Domenico Benvenuto, Ginevra Bugani, Alessandra D'Auria, Eleonora Coratti, Giulia Babini, Ugo Moens, Eugenio Nelson Cavallari, Carlo Torti, Guido Antonelli, Massimo Ciccozzi, Alessandra Pierangeli, Gabriella d'Ettorre, Carolina Scagnolari, Valeria Pietropaolo   +15 more
wiley   +1 more source

High-throughput drug screen identifies calcium and calmodulin inhibitors that reduce JCPyV infection

Antiviral Research
JC polyomavirus (JCPyV) is a nonenveloped, double-stranded DNA virus that infects the majority of the population. Immunocompetent individuals harbor infection in their kidneys, while severe immunosuppression can result in JCPyV spread to the brain, causing the neurodegenerative disease progressive multifocal leukoencephalopathy (PML).
Avery C.S. Bond, Mason A. Crocker, Michael P. Wilczek, Jeanne K. DuShane, Amanda L. Sandberg, Lucas J. Bennett, Nicholas R. Leclerc, Melissa S. Maginnis   +7 more
openaire   +2 more sources

Association between colorectal carcinoma and the oncogenic polyomavirus JCPyV

, 2016
Il carcinoma al colon-retto (CRC) può essere di tipo sporadico, familiare o ereditario. La forma sporadica, comprende circa il 70% dei casi di CRC, mentre le alterazioni del DNA nelle cellule somatiche sono causate da diversi fattori.
PIETROBON, SILVIA
core  

A Retrograde Trafficking Inhibitor of Ricin and Shiga-Like Toxins Inhibits Infection of Cells by Human and Monkey Polyomaviruses

mBio, 2013
Polyomaviruses are ubiquitous pathogens that cause severe disease in immunocompromised individuals. JC polyomavirus (JCPyV) is the causative agent of the fatal demyelinating disease progressive multifocal leukoencephalopathy (PML), whereas BK ...
Christian D. S. Nelson, Dan W. Carney, Aaron Derdowski, Alex Lipovsky, Gretchen V. Gee, Bethany O’Hara, Paul Williard, Daniel DiMaio, Jason K. Sello, Walter J. Atwood   +9 more
doaj   +1 more source

Highly restrictive and directional penetration of the blood cerebral spinal fluid barrier by JCPyV

PLOS Pathogens
The human polyomavirus JCPyV is an opportunistic pathogen that infects greater than 60% of the world’s population. The virus establishes a persistent and asymptomatic infection in the urogenital system but can cause a fatal demyelinating disease in immunosuppressed or immunomodulated patients following invasion of the CNS.
Bethany A. O’Hara, Avraham S. Lukacher, Kaitlin Garabian, Jacob Kaiserman, Evan MacLure, Hiroshi Ishikawa, Horst Schroten, Sheila A. Haley, Walter J. Atwood   +8 more
openaire   +3 more sources

Progressive Multifocal Leukoencephalopathy-Associated Mutations in the JC Polyomavirus Capsid Disrupt Lactoseries Tetrasaccharide c Binding

mBio, 2013
The human JC polyomavirus (JCPyV) is the causative agent of the fatal, demyelinating disease progressive multifocal leukoencephalopathy (PML). The Mad-1 prototype strain of JCPyV uses the glycan lactoseries tetrasaccharide c (LSTc) and serotonin receptor
Melissa S. Maginnis, Luisa J. Ströh, Gretchen V. Gee, Bethany A. O’Hara, Aaron Derdowski, Thilo Stehle, Walter J. Atwood   +6 more
doaj   +1 more source

Additional file 2 of The differential presence of human polyomaviruses, JCPyV and BKPyV, in prostate cancer and benign prostate hypertrophy tissues

, 2021
Additional file 2: Table S2. Characteristics of benign prostate hypertrophy (BPH) samples and summary of the analysis of human polyomavirus (JCPyV and BKPyV) DNA and ...
Chunnun Chao (11600522), Chunliang Tung (11600519), Shupei Huang (4975709), Chenghuang Shen (11600516), Peilain Chen (11600528), Yeongchin Jou (11600525), Deching Chang (2847464), Menghsiao Meng (163766)   +7 more
core   +1 more source

EV mediated infection of SVG-A cells with externally associated virus can be blocked with anti-JCPyV antisera.

, 2020
(A) EVJC+ from infected CPEL cells were concentrated by differential ultracentrifugation and purified over a qEV column. Western blot analysis of each fraction showed that the viral protein VP1 and the EV marker CD9 co-purifed in fraction 7. (B) EVs from
Sheila A. Haley (8532747), Walter J. Atwood (469045), Bethany A. O’Hara (8532741), Jenna Morris-Love (5904533), Gretchen V. Gee (8532744)   +4 more
core   +1 more source