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JC Polyomavirus Infection: A Narrative Review [PDF]
Infectious Diseases and TherapyProgressive multifocal leukoencephalopathy (PML) is a devastating and often fatal central nervous system infection caused by John Cunningham polyomavirus virus (JCPyV).
Meital Elbaz +3 more
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The oncogenic roles of JC polyomavirus in cancer [PDF]
Frontiers in Oncology, 2022 JC polyomavirus (JCPyV) belongs to the human polyomavirus family. Based on alternative splicing, the early region encodes the large and small T antigens, while the late region encodes the capsid structural proteins (VP1, VP2, and VP3) and the agnoprotein.
Hua-chuan Zheng, Hang Xue, Cong-yu Zhang
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Biogenesis of JC polyomavirus associated extracellular vesicles [PDF]
Journal of Extracellular Biology, 2022 JC polyomavirus (JCPyV) is a small, non‐enveloped virus that persists in the kidney in about half the adult population. In severely immune‐compromised individuals JCPyV causes the neurodegenerative disease progressive multifocal leukoencephalopathy (PML)
Jenna Morris‐Love +8 more
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JC Polyomavirus-Associated Nephropathy Case Report: Clinical and Laboratory Learning [PDF]
British Journal of Biomedical ScienceIntroductionJohn Cunningham (JC) virus is commonly associated with progressive multifocal leukoencephalopathy. However, this polyomavirus can also be a rare etiological agent of nephropathy in renal transplant recipients.
Rachael M. Tomb +5 more
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Current Perspectives on JC Polyomavirus Transmission and Associated Diseases: Implications for Prevention in Risk Populations [PDF]
VirusesJC polyomavirus (JCPyV) is a worldwide-distributed human virus. Primary infection with JCPyV is usually asymptomatic and followed by a lifelong persistent infection.
Joana M Oliveira +2 more
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JC Polyomavirus Nephropathy: A Rare Complication Late after Kidney Transplantation [PDF]
Case Reports in Nephrology and DialysisIntroduction: JC-polyomavirus-associated nephropathy (JC-PVAN) is a rare cause of allograft dysfunction with only a few cases described in the literature.
Jennifer Scotti Gerber +4 more
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GPCR Inhibitors Have Antiviral Properties against JC Polyomavirus Infection [PDF]
VirusesJC polyomavirus (JCPyV) infects the majority of the population and initially establishes a persistent but asymptomatic infection of the kidneys. In healthy individuals, the infection remains controlled by the host immune system, but for individuals ...
Amanda L. Sandberg +9 more
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Insights into the genetic characteristics, clustering patterns, and phylogeographic dynamics of the JC polyomavirus, 1993 to 2023 [PDF]
Virus ResearchThe human JC polyomavirus (JCV) is a widespread, neurotropic, opportunistic pathogen responsible for progressive multifocal leukoencephalopathy (PML) as well as other diseases in immunosuppressed individuals, including granule cell neuronopathy, JCV ...
Pir Tariq Shah +5 more
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Viruses, 2022 A recent paper in Viruses investigates the impact of the JC polyomavirus (JCPyV) microRNA on the replication of different JCPyV strains. Unfortunately, one of the cell lines used, the human fetal glial cell line SVGp12, is productively infected by the ...
Stian Henriksen +1 more
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AIDS Research and Therapy, 2020 The human neurotropic virus JC Polyomavirus, a member of the Polyomaviridae family, is the opportunistic infectious agent causing progressive multifocal leukoencephalopathy, typically in immunocompromised individuals.
Vijay Harypursat +3 more
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