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JC Polyomavirus Infection: A Narrative Review [PDF]

Infectious Diseases and Therapy
Progressive multifocal leukoencephalopathy (PML) is a devastating and often fatal central nervous system infection caused by John Cunningham polyomavirus virus (JCPyV).
Meital Elbaz, Dafna Yahav, Yair Mina, Alaa Atamna   +3 more
doaj   +4 more sources

Biogenesis of JC polyomavirus associated extracellular vesicles [PDF]

Journal of Extracellular Biology, 2022
JC polyomavirus (JCPyV) is a small, non‐enveloped virus that persists in the kidney in about half the adult population. In severely immune‐compromised individuals JCPyV causes the neurodegenerative disease progressive multifocal leukoencephalopathy (PML)
Jenna Morris‐Love, Bethany A. O'Hara, Gretchen V. Gee, Aisling S. Dugan, Ryan S. O'Rourke, Brandon E. Armstead, Benedetta Assetta, Sheila A. Haley, Walter J. Atwood   +8 more
doaj   +5 more sources

The oncogenic roles of JC polyomavirus in cancer [PDF]

Frontiers in Oncology, 2022
JC polyomavirus (JCPyV) belongs to the human polyomavirus family. Based on alternative splicing, the early region encodes the large and small T antigens, while the late region encodes the capsid structural proteins (VP1, VP2, and VP3) and the agnoprotein.
Hua-chuan Zheng, Hang Xue, Cong-yu Zhang
doaj   +4 more sources

Rad51 activates polyomavirus JC early transcription. [PDF]

PLoS ONE, 2014
The human neurotropic polyomavirus JC (JCV) causes the fatal CNS demyelinating disease progressive multifocal leukoencephalopathy (PML). JCV infection is very common and after primary infection, the virus is able to persist in an asymptomatic state ...
Martyn K White, Rafal Kaminski, Kamel Khalili, Hassen S Wollebo   +3 more
doaj   +4 more sources

Should SVGp12 Be Used for JC Polyomavirus Studies? Comment on Prezioso et al. COS-7 and SVGp12 Cellular Models to Study JCPyV Replication and MicroRNA Expression after Infection with Archetypal and Rearranged-NCCR Viral Strains. Viruses 2022, 14, 2070 [PDF]

Viruses, 2022
A recent paper in Viruses investigates the impact of the JC polyomavirus (JCPyV) microRNA on the replication of different JCPyV strains. Unfortunately, one of the cell lines used, the human fetal glial cell line SVGp12, is productively infected by the ...
Stian Henriksen, Christine Hanssen Rinaldo   +1 more
doaj   +2 more sources

Characterization of JC Polyomavirus Entry by Serotonin Receptors [PDF]

Proceedings, 2020
JC polyomavirus (JCPyV) causes a lifelong persistent infection in the kidney in the majority of the population. In severely immunocompromised individuals, JCPyV can become reactivated, spread in the central nervous system, and infect glial cells ...
Melissa Maginnis, Colleen L. Mayberry, Kashif Mehmood, Matthew Parent, Samuel Hess   +4 more
doaj   +2 more sources

Association between the JC polyomavirus infection and male infertility. [PDF]

PLoS ONE, 2012
In recent years the incidence of male infertility has increased. Many risk factors have been taken into consideration, including viral infections. Investigations into viral agents and male infertility have mainly been focused on human papillomaviruses ...
Manola Comar, Manola Comar, Nunzia Zanotta, Eleonora Croci, Immacolata Murru, Roberto Marci, Cecilia Pancaldi, Ornella Dolcet, Stefania Luppi, Monica Martinelli, Elena Giolo, Giuseppe Ricci, Mauro Tognon   +12 more
doaj   +5 more sources

Epigenetic regulation of polyomavirus JC [PDF]

Virology Journal, 2013
Abstract Background Polyomavirus JC (JCV) causes the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), which occurs almost exclusively in people with immune deficiencies, such as HIV-1/AIDS patients. JCV infection is very common and usually occurs early in life. After primary infection, virus
Wollebo, Hassen S, Woldemichaele, Baheru, Khalili, Kamel, Safak, Mahmut, White, Martyn K   +4 more
openaire   +2 more sources

JC Polyomavirus Infections in Transplant Patients [PDF]

Journal of Transplantation Technologies & Research, 2012
The polyomavirus JC virus (JCV) is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as Progressive Multifocal Leukoencephalopathy (PML ...
S. Delbue, M. Ferraresso
openaire   +1 more source

JC polyomavirus DNA detection in clinical practice

Journal of Clinical Virology, 2022
There are limited data about the use and clinical value of JC polyomavirus (JCPyV) DNA detection in various clinical indications.We reviewed the clinical records of 410 patients from whom cerebrospinal fluid (CSF), plasma, urine, or tissue samples had been collected for JCPyV DNA polymerase chain reaction (PCR) between 2012 and 2018.JCPyV DNA was ...
Kartau, Marge, Auvinen, Eeva, Verkkoniemi-Ahola, Auli, Mannonen, Laura, Helanterä, Ilkka, Anttila, Veli-Jukka   +5 more
openaire   +3 more sources