Results 21 to 30 of about 4,990 (166)

Small‐molecule inhibitors of JC polyomavirus infection [PDF]

Journal of Peptide Science, 2014
The JC polyomavirus (JCPyV) infects approximately 50% of the human population. In healthy individuals, the infection remains dormant and asymptomatic, but in immuno‐suppressed patients, it can cause progressive multifocal leukoencephalopathy (PML), a potentially fatal demyelinating disease.
Achani, Yatawara, Gabriel, Gaidos, Chamila N, Rupasinghe, Bethany A, O'Hara, Maria, Pellegrini, Walter J, Atwood, Dale F, Mierke   +6 more
openaire   +2 more sources

A polyomavirus peptide binds to the capsid VP1 pore and has potent antiviral activity against BK and JC polyomaviruses

eLife, 2020
In pursuit of therapeutics for human polyomaviruses, we identified a peptide derived from the BK polyomavirus (BKV) minor structural proteins VP2/3 that is a potent inhibitor of BKV infection with no observable cellular toxicity.
Joshua R Kane, Susan Fong, Jacob Shaul, Alexandra Frommlet, Andreas O Frank, Mark Knapp, Dirksen E Bussiere, Peter Kim, Elizabeth Ornelas, Carlos Cuellar, Anastasia Hyrina, Johanna R Abend, Charles A Wartchow   +12 more
doaj   +1 more source

Taking the Scenic Route: Polyomaviruses Utilize Multiple Pathways to Reach the Same Destination

Viruses, 2020
Members of the Polyomaviridae family differ in their host range, pathogenesis, and disease severity. To date, some of the most studied polyomaviruses include human JC, BK, and Merkel cell polyomavirus and non-human subspecies murine and simian virus 40 ...
Colleen L. Mayberry, Melissa S. Maginnis
doaj   +1 more source

Polyomavirus infections and its clinical relevance in cancer patients: A Prospective Study

Journal of Infection and Public Health, 2017
Summary: BK and JC polyomaviruses (PyV) have been demonstrated to be associated with the pathogenesis of various human cancers. We aimed to investigate the impact of BK and JC polyomavirus infections on several clinical parameters in different human ...
Samah A. Loutfy, Manar M. Moneer, Salem E. Salem, Emad A. El-Moniem Abada, Entsar A. El-Moniem Ahmed, Lamiaa H. Ibrahim, EL-Chaimaa B. Mohamed   +6 more
doaj   +1 more source

Efficient uptake of blood-borne BK and JC polyomavirus-like particles in endothelial cells of liver sinusoids and renal vasa recta. [PDF]

PLoS ONE, 2014
Liver sinusoidal endothelial cells (LSECs) are specialized scavenger cells that mediate high-capacity clearance of soluble waste macromolecules and colloid material, including blood-borne adenovirus.
Jaione Simon-Santamaria, Christine Hanssen Rinaldo, Piotr Kardas, Ruomei Li, Ivana Malovic, Kjetil Elvevold, Peter McCourt, Bård Smedsrød, Hans H Hirsch, Karen Kristine Sørensen   +9 more
doaj   +1 more source

Establishment of COS‐JC cells persistently producing archetype JC polyomavirus [PDF]

Microbiology and Immunology, 2018
ABSTRACTJC polyomavirus (JCPyV) is the causative agent of progressive multifocal leukoencephalopathy (PML), a demyelinating disease of the central nervous system in immunocompromised patients. Archetype JCPyV circulates in the human population. There have been several reports of archetype JCPyV replication in cultured cells, in which propagation was ...
Souichi, Nukuzuma, Chiyoko, Nukuzuma, Masanori, Kameoka, Shigeki, Sugiura, Kazuo, Nakamichi, Takafumi, Tasaki, Koushi, Hidaka, Tsutomu, Takegami   +7 more
openaire   +2 more sources

The Potential Role of BK and JC Polyomaviruses in Urothelial Cancer

The Iraqi Journal of Medical Sciences
Background:    BK and JC polyomaviruses are perceived as the two most common human polyomaviruses (HPyVs). These two viruses inhabit the epithelial surfaces of the bladder and kidney as the primary site of replication and latency.
Kawther A. AlMalaki, Asmaa' B. Al-Obaidi, Haider F. Ghazi   +2 more
doaj   +3 more sources

ERK Is a Critical Regulator of JC Polyomavirus Infection [PDF]

Journal of Virology, 2018
ABSTRACTThe human JC polyomavirus (JCPyV) infects the majority of the population worldwide and presents as an asymptomatic, persistent infection in the kidneys. In individuals who are immunocompromised, JCPyV can become reactivated and cause a lytic infection in the central nervous system resulting in the fatal, demyelinating disease progressive ...
Jeanne K, DuShane, Michael P, Wilczek, Colleen L, Mayberry, Melissa S, Maginnis   +3 more
openaire   +2 more sources

Infectious Entry and Neutralization of Pathogenic JC Polyomaviruses

Cell Reports, 2017
Summary: Progressive multifocal leukoencephalopathy (PML) is a lethal brain disease caused by uncontrolled replication of JC polyomavirus (JCV). JCV strains recovered from the brains of PML patients carry mutations that prevent the engagement of ...
Eileen M. Geoghegan, Diana V. Pastrana, Rachel M. Schowalter, Upasana Ray, Wei Gao, Mitchell Ho, Gary T. Pauly, Dina M. Sigano, Campbell Kaynor, Ellen Cahir-McFarland, Benoit Combaluzier, Jan Grimm, Christopher B. Buck   +12 more
doaj   +1 more source

Persistence and pathogenesis of the neurotropic polyomavirus JC [PDF]

Annals of Neurology, 2015
Many neurological diseases of the central nervous system (CNS) are underpinned by malfunctions of the immune system, including disorders involving opportunistic infections. Progressive multifocal leukoencephalopathy (PML) is a lethal CNS demyelinating disease caused by the human neurotropic polyomavirus JC (JCV) and is found almost exclusively in ...
Hassen S, Wollebo, Martyn K, White, Jennifer, Gordon, Joseph R, Berger, Kamel, Khalili   +4 more
openaire   +2 more sources