Results 11 to 20 of about 5,167 (169)

Rad51 activates polyomavirus JC early transcription. [PDF]

PLoS ONE, 2014
The human neurotropic polyomavirus JC (JCV) causes the fatal CNS demyelinating disease progressive multifocal leukoencephalopathy (PML). JCV infection is very common and after primary infection, the virus is able to persist in an asymptomatic state ...
Martyn K White, Rafal Kaminski, Kamel Khalili, Hassen S Wollebo   +3 more
doaj   +4 more sources

Association between the JC polyomavirus infection and male infertility. [PDF]

PLoS ONE, 2012
In recent years the incidence of male infertility has increased. Many risk factors have been taken into consideration, including viral infections. Investigations into viral agents and male infertility have mainly been focused on human papillomaviruses ...
Manola Comar, Manola Comar, Nunzia Zanotta, Eleonora Croci, Immacolata Murru, Roberto Marci, Cecilia Pancaldi, Ornella Dolcet, Stefania Luppi, Monica Martinelli, Elena Giolo, Giuseppe Ricci, Mauro Tognon   +12 more
doaj   +5 more sources

JC Polyomavirus in Prostate Cancer-Friend or Foe? [PDF]

Cancers (Basel)
Background/Objectives: Recently, many researchers have evaluated various viruses, including polyomaviruses (JCV, BKV) and EBV, as potential factors playing a role in the development and/or progression of prostate cancer (PCa), one of the most common cancers in men.
Kiś J, Sikora D, Jarosz MJ, Polz-Dacewicz M.   +3 more
europepmc   +3 more sources

Neurovascular pericytes are susceptible to infection by JC polyomavirus. [PDF]

J Virol
ABSTRACT Progressive multifocal leukoencephalopathy (PML), an often-fatal neurodegenerative disease, is caused by the neuroinvasive polyomavirus JCPyV. Peripheral organs, including the kidney, are the site of lifelong persistent infections that are asymptomatic. In a subset of immunosuppressed
O'Hara BA, Garabian K, Yuan W, Atwood WJ, Haley SA.   +4 more
europepmc   +3 more sources

Epigenetic regulation of polyomavirus JC [PDF]

Virology Journal, 2013
Abstract Background Polyomavirus JC (JCV) causes the CNS demyelinating disease progressive multifocal leukoencephalopathy (PML), which occurs almost exclusively in people with immune deficiencies, such as HIV-1/AIDS patients. JCV infection is very common and usually occurs early in life. After primary infection, virus
Wollebo, Hassen S, Woldemichaele, Baheru, Khalili, Kamel, Safak, Mahmut, White, Martyn K   +4 more
openaire   +2 more sources

JC Polyomavirus Infections in Transplant Patients [PDF]

Journal of Transplantation Technologies & Research, 2012
The polyomavirus JC virus (JCV) is a small nonenveloped DNA virus that asymptomatically infects about 80% of healthy adults and establishes latency in the kidney tissue. In case of immunodeficient hosts, JCV can lytically infect the oligodendrocytes, causing a fatal demyelinating disease, known as Progressive Multifocal Leukoencephalopathy (PML ...
S. Delbue, M. Ferraresso
openaire   +1 more source

Human polyomavirus JC virus genome [PDF]

Journal of Virology, 1984
The complete DNA sequence of the human JC virus, which was found to consist of 5,130 nucleotide pairs, is presented. The amino acid sequence of six proteins could be deduced: the early, nonstructural proteins, large T and small t antigens; the late capsid proteins, VP1, VP2, and VP3; and the agnogene product encoded within the late leader sequence ...
R J, Frisque, G L, Bream, M T, Cannella
openaire   +2 more sources

JC polyomavirus DNA detection in clinical practice

Journal of Clinical Virology, 2022
There are limited data about the use and clinical value of JC polyomavirus (JCPyV) DNA detection in various clinical indications.We reviewed the clinical records of 410 patients from whom cerebrospinal fluid (CSF), plasma, urine, or tissue samples had been collected for JCPyV DNA polymerase chain reaction (PCR) between 2012 and 2018.JCPyV DNA was ...
Kartau, Marge, Auvinen, Eeva, Verkkoniemi-Ahola, Auli, Mannonen, Laura, Helanterä, Ilkka, Anttila, Veli-Jukka   +5 more
openaire   +3 more sources

Phosphoinositide 3′-Kinase γ Facilitates Polyomavirus Infection

Viruses, 2020
Polyomaviruses are small, non-enveloped DNA tumor viruses that cause serious disease in immunosuppressed people, including progressive multifocal leukoencephalopathy (PML) in patients infected with JC polyomavirus, but the molecular events mediating ...
Paul Clark, Gretchen V. Gee, Brandon S. Albright, Benedetta Assetta, Ying Han, Walter J. Atwood, Daniel DiMaio   +6 more
doaj   +1 more source

Polyomaviruses BK and JC DNA infection in peripheral blood cells from blood donors

Brazilian Journal of Infectious Diseases, 2019
Objectives: To investigate the prevalence of human polyomavirus (BK and JC viruses) infection in peripheral blood mononuclear cells of healthy blood donors. Methods: The study included 250 healthy blood donors.
Malihe Fathi Haghighi, Noorossadat Seyyedi, Ali Farhadi, Farahnaz Zare, Leila Kasraian, Gholam Reza Refiei Dehbidi, Reza Ranjbaran, Abbas Behzad-Behbahani   +7 more
doaj   +3 more sources