Results 71 to 80 of about 1,015 (152)

Cellular Immunity Against BK Polyomavirus in Kidney Transplant Recipients: A Comprehensive Review

Transplant Infectious Disease, Volume 27, Issue 1, January/February 2025.
ABSTRACT BK polyomavirus (BKPyV) is an important opportunistic viral infection that complicates kidney transplantation. Uncontrolled viral replication may result in BKPyV‐associated nephropathy (BKPyVAN), a major cause of premature allograft damage and failure.
Mohammed Al‐Talib, Anna Skaria, Siân Griffin   +2 more
wiley   +1 more source

High-Throughput Characterization of Viral and Cellular Protein Expression Patterns During JC Polyomavirus Infection

Frontiers in Microbiology, 2019
JC polyomavirus (JCPyV) is a ubiquitous human pathogen and the causative agent of a fatal demyelinating disease in severely immunocompromised individuals.
Jeanne K. DuShane, Michael P. Wilczek, Mason A. Crocker, Melissa S. Maginnis, Melissa S. Maginnis   +4 more
doaj   +1 more source

Exploring the Causal Relationship Between Mitochondrial DNA Copy Number, Antibody‐Mediated Immune Response, and Risk of Kidney Stone Disease: A Mendelian Randomization Study

International Journal of Clinical Practice, Volume 2025, Issue 1, 2025.
Background Given the high recurrence rate of kidney stone disease (KSD), surgical interventions alone are not an optimal solution. Antibody‐mediated immune responses and mitochondrial dysfunction influence the risk and prognosis of KSD; however, the exact causal mechanisms underlying these relationships remain unclear.
Wenqiong Chen, Yan Qian, Zhongqiu Xie
wiley   +1 more source

Mouse polyomavirus infection induces lamin reorganisation

The FEBS Journal, Volume 291, Issue 23, Page 5133-5155, December 2024.
Here, we investigated the roles of lamins as important nuclear proteins in the replication cycle of the mouse polyomavirus. We detected accumulation of the major capsid protein VP1 under the nuclear lamina, defects in nuclear lamina staining and different lamin A/C phosphorylation patterns following viral infection.
Kateřina Bruštíková, Boris Ryabchenko, Sandra Žáčková, Vojtěch Šroller, Jitka Forstová, Lenka Horníková   +5 more
wiley   +1 more source

Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus

Cell Reports, 2019
Summary: JC polyomavirus (JCPyV) is a ubiquitous human pathogen that causes progressive multifocal leukoencephalopathy (PML). The entry receptors for JCPyV belong to the 5-hydroxytryptamine 2 receptor (5-HT2R) family, but how individual members of the ...
Benedetta Assetta, Jenna Morris-Love, Gretchen V. Gee, Abigail L. Atkinson, Bethany A. O’Hara, Melissa S. Maginnis, Sheila A. Haley, Walter J. Atwood   +7 more
doaj   +1 more source

BK Polyomavirus Infection of Bladder Microvascular Endothelial Cells Leads to the Activation of the cGAS‐STING Pathway

Journal of Medical Virology, Volume 96, Issue 11, November 2024.
ABSTRACT BK polyomavirus (BKPyV) infection in humans is usually asymptomatic but ultimately results in viral persistence. In immunocompromised hosts, virus reactivation can lead to nephropathy or hemorrhagic cystitis. The urinary tract serves as a silent reservoir for the virus.
Kateřina Bruštíková, Boris Ryabchenko, David Liebl, Lenka Horníková, Jitka Forstová, Sandra Huérfano   +5 more
wiley   +1 more source

Advancing the field of viroporins—Structure, function and pharmacology: IUPHAR Review 39

British Journal of Pharmacology, Volume 181, Issue 22, Page 4450-4490, November 2024.
Viroporins possess important potential as antiviral targets due to their critical roles during virus life cycles, spanning from virus entry to egress. Although the antiviral amantadine targets the M2 viroporin of influenza A virus, successful progression of other viroporin inhibitors into clinical use remains challenging.
Kira Devantier, Viktoria M. S. Kjær, Stephen Griffin, Birthe B. Kragelund, Mette M. Rosenkilde   +4 more
wiley   +1 more source

Merkel Cell Polyomavirus—Pathophysiology and Treatment in the Era of Gene‐Targeted Therapies

Reviews in Medical Virology, Volume 34, Issue 5, September 2024.
ABSTRACT Merkel cell polyomavirus (MCPyV) is a significant contributor to the development of Merkel cell carcinoma (MCC), an aggressive skin cancer with high recurrence and a low survival rate. In fact, it is the deadliest skin cancer. The precise routes of transmission for MCPyV‐positive MCC remain unclear, but several factors may trigger its ...
Trairong Chokwassanasakulkit, Nigel A. J. McMillan   +1 more
wiley   +1 more source

Increased prevalence of Human Polyomavirus JC viruria in Chronic Inflammatory Rheumatic Diseases patients in treatment with anti-TNF α: a 18 month follow-up study.

Frontiers in Microbiology, 2016
Chronic inflammatory rheumatic diseases (CIRDs) are immune-mediated pathologies involving joints. To date, TNFα-blocking agents administration is the most promising therapy, although these treatments are associated with an increased Polyomavirus JC ...
Donatella Maria Rodio, Elena eAnzivino, Monica eMischitelli, Anna eBellizzi, Rossana eScrivo, Daniela eScribano, Gianlorenzo eConte, Carla ePrezioso, Maria eTrancassini, Guido eValesini, Anna Teresa ePalamara, Valeria ePietropaolo   +11 more
doaj   +1 more source

High rates of anal Merkel Cell Polyomavirus and HPV co‐infection among people living with HIV

Journal of Medical Virology, Volume 96, Issue 8, August 2024.
Abstract Knowledge of Human Polyomavirus (HPyV) infection in the anal area and its association with sexually transmitted infections such as Human Papillomavirus (HPV) and Human Immunodeficiency Virus (HIV) remains limited. Therefore, anal specimens from 150 individuals of both sexes were analyzed for screening purposes.
Sara Passerini, Matteo Fracella, Domenico Benvenuto, Ginevra Bugani, Alessandra D'Auria, Eleonora Coratti, Giulia Babini, Ugo Moens, Eugenio Nelson Cavallari, Carlo Torti, Guido Antonelli, Massimo Ciccozzi, Alessandra Pierangeli, Gabriella d'Ettorre, Carolina Scagnolari, Valeria Pietropaolo   +15 more
wiley   +1 more source