Results 21 to 30 of about 1,462 (171)

Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells [PDF]

International Journal of Molecular Sciences, 2021
Several classes of immunomodulators are used for treating relapsing-remitting multiple sclerosis (RRMS). Most of these disease-modifying therapies, except teriflunomide, carry the risk of progressive multifocal leukoencephalopathy (PML), a severely debilitating, often fatal virus-induced demyelinating disease.
Bethany A. O’Hara, Gretchen V. Gee, Sheila A. Haley, Jenna Morris-Love, Charlotte Nyblade, Chris Nieves, Barbara A. Hanson, Xin Dang, Timothy J. Turner, Jeffrey M. Chavin, Alex Lublin, Igor J. Koralnik, Walter J. Atwood   +12 more
openaire   +4 more sources

High-level JCPyV viruria after kidney transplantation—Clinical and histopathological findings [PDF]

Journal of Clinical Virology, 2016
The significance of JC polyomavirus (JCPyV) after kidney transplantation ranges from irrelevant to full-blown nephropathy or PML.To investigate the clinical significance of high-level JCPyV viruria and JCPyV primary infections after kidney transplantation.JCPyV viruria was detected in routine screening by quantitative real-time PCR in 40/238 kidney ...
Helantera, I., Hirsch, H. H., Auvinen, E., Mannonen, L., Nummi, M., Wernli, M., Ortiz, F., Raisanen-Sokolowski, A., Lempinen, M., Lautenschlager, I.   +9 more
openaire   +7 more sources

Mother-to-child transmission of oncogenic polyomaviruses BKPyV, JCPyV and SV40

Journal of Infection, 2020
Polyomavirus (PyV) infections have been associated with different diseases. BK (BKPyV), JC (JCPyV) and simian virus 40 (SV40) are the three main PyVs whose primary infection occurs early in life. Their vertical transmission was investigated in this study.PyV sequences were analyzed by the digital droplet PCR in blood, serum, placenta, amniotic fluid ...
Elisa Mazzoni, Elena Pellegrinelli, Chiara Mazziotta, Carmen Lanzillotti, John Charles Rotondo, Ilaria Bononi, Maria Rosa Iaquinta, Marco Manfrini, Fortunato Vesce, Mauro Tognon, Fernanda Martini   +10 more
openaire   +3 more sources

Quantification and Stability of Human Adenoviruses and Polyomavirus JCPyV in Wastewater Matrices [PDF]

Applied and Environmental Microbiology, 2006
ABSTRACT Human adenoviruses (HAdV) and human polyomavirus JCPyV have been previously proposed as indicators of fecal viral contamination in the environment. Different wastewater matrices have been analyzed by applying real-time quantitative PCR procedures for the presence, quantity, and stability of a wide diversity of excreted HAdV and JCPyV.
Silvia, Bofill-Mas, Nestor, Albinana-Gimenez, Pilar, Clemente-Casares, Ayalkibet, Hundesa, Jesus, Rodriguez-Manzano, Annika, Allard, Miquel, Calvo, Rosina, Girones   +7 more
openaire   +3 more sources

Human polyomavirus BKPyV and JCPyV serostatus has no impact on women´s human papillomavirus infection outcome [PDF]

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionPolyomaviruses have both structural and functional similarities with papillomaviruses. Accordingly, their role in human papillomavirus (HPV) associated malignancies has been studied with conflicting results. Our goal was to disclose any association between BK (BKPyV) and/or JC (JCPyV) polyomavirus serology and HPV data derived from Finnish ...
Hanna K. Laine, Hanna K. Laine, Tim Waterboer, Kari Syrjänen, Seija Grenman, Karolina Louvanto, Karolina Louvanto, Stina Syrjänen, Stina Syrjänen   +8 more
core   +9 more sources

Inhibition of JCPyV infection mediated by targeted viral genome editing using CRISPR/Cas9 [PDF]

Scientific Reports, 2016
AbstractProgressive multifocal leukoencephalopathy (PML) is a debilitating disease resulting from infection of oligodendrocytes by the JC polyomavirus (JCPyV). Currently, there is no anti-viral therapeutic available against JCPyV infection. The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system ...
Chou, Yi-Ying, Krupp, Annabel, Kaynor, Campbell, Gaudin, Raphael, Ma, Minghe, Cahir-Mcfarland, Ellen, Kirchhausen, Tom   +6 more
openaire   +6 more sources

Alterations of the miR-126-3p/POU2AF1/Spi-B Axis and JCPyV Reactivation in Multiple Sclerosis Patients Receiving Natalizumab [PDF]

Frontiers in Neurology, 2022
Natalizumab (NTZ) can reactivate human polyomavirus John Cunningham polyomavirus (JCPyV) latent infection and lead to progressive multifocal leukoencephalopathy (PML). NTZ modulates the expression of microRNA-126-3p (miR-126-3p) and its target genes, Spi-
Roberta Mancuso, Simone Agostini, Ambra Hernis, Domenico Caputo, Daniela Galimberti, Daniela Galimberti, Elio Scarpini, Elio Scarpini, Mario Clerici, Mario Clerici   +9 more
doaj   +2 more sources

JCPyV NCCR analysis in PML patients with different risk factors: exploring common rearrangements as essential changes for neuropathogenesis [PDF]

Virology Journal, 2020
Abstract Background During severe immunosuppression or treatment with specific biological drugs, human polyomavirus JC (JCPyV) may establish a lytic infection in oligodendrocytes, leading to progressive multifocal leukoencephalopathy (PML).
Ciardi M. R., Zingaropoli M. A., Iannetta M., Prezioso C., Perri V., Pasculli P., Lichtner M., D'Ettorre G., Altieri M., Conte A., Pietropaolo V., Mastroianni C. M., Vullo V.   +12 more
openaire   +8 more sources

Genetic diversity of the JC polyomavirus (JCPyV) and mitochondrial DNA ancestry in Misiones, Argentina

Infection, Genetics and Evolution, 2019
The use of human and viral genetic markers offers a novel way to study human migration in multiethnic populations of Latin America.Our goal was to characterize the genetic diversity and geographical origins of JC Polyomavirus (JCPyV) and the genetic ancestry of mitochondrial DNA (mtDNA) in inhabitants from 25 de Mayo, Misiones-Argentina, a small ...
Sanabria, Daiana Jimena, Mojsiejczuk, Laura Noelia, Torres, Carolina, Meyer, Alejandro G., Mbayed, Viviana Andrea, Liotta, Domingo Javier, Campos, Rodolfo Hector, Schurr, Theodore G., Badano, Ines   +8 more
openaire   +4 more sources

Identification of JC polyomavirus in upper respiratory samples from Portuguese children [PDF]

Heliyon
Background: JC polyomavirus (JCPyV) is ubiquitous in the human population and the causative agent of a rare, fatal and demyelinating disease of the central nervous system named Progressive Multifocal Leukoencephalopathy (PML).
Joana M. Oliveira, Daniela Veiga, Helena Martins, Cristina Luxo, Ana M. Matos   +4 more
doaj   +2 more sources