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Frontiers in Immunology, 2021 BackgroundMany investigations reported the association between human tumors and JCPyV, a polyomavirus with oncogenic potential. The association has been supported by studies that found JCPyV footprints in CRC and gliomas of different types. Indeed, JCPyV
Elena Torreggiani +7 more
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Pseudovirus mimics cell entry and trafficking of the human polyomavirus JCPyV [PDF]
Virus Research, 2013 The normally asymptomatic human polyomavirus, JCPyV, is the causative agent of a rare but fatal demyelinating disease known as progressive multifocal leukoencephalopathy (PML). Individuals at risk for developing PML include those with AIDS, with other underlying immunosuppressive diseases, and in patients treated with immunomodulatory regimens.
Gretchen V, Gee +3 more
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Polyomavirus Wakes Up and Chooses Neurovirulence
Viruses, 2023 JC polyomavirus (JCPyV) is a human-specific polyomavirus that establishes a silent lifelong infection in multiple peripheral organs, predominantly those of the urinary tract, of immunocompetent individuals.
Arrienne B. Butic +3 more
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Quantification and Stability of Human Adenoviruses and Polyomavirus JCPyV in Wastewater Matrices [PDF]
Applied and Environmental Microbiology, 2006 ABSTRACT Human adenoviruses (HAdV) and human polyomavirus JCPyV have been previously proposed as indicators of fecal viral contamination in the environment. Different wastewater matrices have been analyzed by applying real-time quantitative PCR procedures for the presence, quantity, and stability of a wide diversity of excreted HAdV and JCPyV.
Silvia, Bofill-Mas +7 more
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The differential presence of human polyomaviruses, JCPyV and BKPyV, in prostate cancer and benign prostate hypertrophy tissues [PDF]
BMC Cancer, 2021 Abstract Background Studies have shown that human polyomavirus infection may be associated with various human cancers. We investigated the potential relationship between the prevalence of JCPyVor BKPyV and prostate cancer (PC) in patients from Taiwan.
Chenghuang Shen +7 more
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Genetic diversity of human polyomavirus JCPyV in Southern California wastewater [PDF]
Journal of Water and Health, 2008 JC Polyomavirus (JCPyV) has the potential to be used as a viral marker for human waste contamination because at least 40% of the human population excretes this virus through its urine. In addition, each of 6 known subtypes of JCPyV is associated with a specific human ethnicity group, which has allowed for tracing of human migration.
Amana, Rafique, Sunny C, Jiang
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Mother-to-child transmission of oncogenic polyomaviruses BKPyV, JCPyV and SV40
Journal of Infection, 2020 Polyomavirus (PyV) infections have been associated with different diseases. BK (BKPyV), JC (JCPyV) and simian virus 40 (SV40) are the three main PyVs whose primary infection occurs early in life. Their vertical transmission was investigated in this study.PyV sequences were analyzed by the digital droplet PCR in blood, serum, placenta, amniotic fluid ...
Elisa Mazzoni +10 more
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Teriflunomide Inhibits JCPyV Infection and Spread in Glial Cells and Choroid Plexus Epithelial Cells [PDF]
International Journal of Molecular Sciences, 2021 Several classes of immunomodulators are used for treating relapsing-remitting multiple sclerosis (RRMS). Most of these disease-modifying therapies, except teriflunomide, carry the risk of progressive multifocal leukoencephalopathy (PML), a severely debilitating, often fatal virus-induced demyelinating disease.
Bethany A. O’Hara +12 more
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Complexities of JC Polyomavirus Receptor-Dependent and -Independent Mechanisms of Infection
Viruses, 2022 JC polyomavirus (JCPyV) is a small non-enveloped virus that establishes lifelong, persistent infection in most of the adult population. Immune-competent patients are generally asymptomatic, but immune-compromised and immune-suppressed patients are at ...
Jenna Morris-Love, Walter J. Atwood
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JCPyV-Induced MAPK Signaling Activates Transcription Factors during Infection [PDF]
International Journal of Molecular Sciences, 2019 JC polyomavirus (JCPyV), a ubiquitous human pathogen, is the etiological agent of the fatal neurodegenerative disease progressive multifocal leukoencephalopathy (PML). Like most viruses, JCPyV infection requires the activation of host-cell signaling pathways in order to promote viral replication processes.
DuShane, Jeanne K. +4 more
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