IFNα and β Mediated JCPyV Suppression through C/EBPβ-LIP Isoform [PDF]
Viruses, 2021 Polyomavirus JC (JCPyV) causes the demyelinating disease progressive multifocal leukoencephalopathy (PML). JCPyV infection is very common in childhood and, under conditions of severe immunosuppression, JCPyV may reactivate to cause PML. JC viral proteins
Dana May +5 more
doaj +4 more sources
The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes [PDF]
Viruses, 2021 JC polyomavirus (JCPyV) is a neuroinvasive pathogen causing a fatal, demyelinating disease of the central nervous system (CNS) known as progressive multifocal leukoencephalopathy (PML).
Michael P. Wilczek +6 more
doaj +4 more sources
Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population [PDF]
Virology Journal, 2017 Background The BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively.
Iqra Hussain +6 more
doaj +5 more sources
Human Polyomavirus JCPyV and Its Role in Progressive Multifocal Leukoencephalopathy and Oncogenesis [PDF]
Frontiers in Oncology, 2019 The human neurotropic virus JCPyV, a member of the Polyomaviridiae family, is the opportunistic infectious agent of Progressive Multifocal Leukoencephalopathy (PML), a fatal disease seen in severe immunosuppressive conditions and, during the last decade,
Luis Del Valle, Sergio Piña-Oviedo
doaj +5 more sources
PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes [PDF]
Cells, 2021 Astrocytes are a main target of JC polyomavirus (JCPyV) in the central nervous system (CNS), where the destruction of these cells, along with oligodendrocytes, leads to the fatal disease progressive multifocal leukoencephalopathy (PML).
Michael P. Wilczek +4 more
doaj +4 more sources
Divergent Trends of Anti-JCPyV Serum Reactivity and Neutralizing Activity in Multiple Sclerosis (MS) Patients during Treatment with Natalizumab [PDF]
Viruses, 2016 The association between natalizumab and progressive multifocal leukoencephalopathy (PML) is established, but a reliable clinical risk stratification flow-chart is lacking. New risk factors are needed, such as the possible role of the anti-JC polyomavirus
Roberta Antonia Diotti +9 more
doaj +7 more sources
Human polyomaviruses JCPyV and MCPyV in urothelial cell carcinoma: a single institution experience [PDF]
Frontiers in Oncology, 2023 ObjectiveUrothelial cell carcinoma (UCC) is the most common type of urinary bladder. JCPyV and BKPyV have been detected in the urine and tissue of urothelial cell carcinomas (UCC) in immunocompetent patients. Here, we investigated the presence of several HPyVs in UCC samples using diverse molecular techniques to study the prevalence of HPyVs in UCC ...
Faisal Klufah +11 more
openaire +4 more sources
JCPyV-Induced MAPK Signaling Activates Transcription Factors during Infection [PDF]
International Journal of Molecular Sciences, 2019 JC polyomavirus (JCPyV), a ubiquitous human pathogen, is the etiological agent of the fatal neurodegenerative disease progressive multifocal leukoencephalopathy (PML). Like most viruses, JCPyV infection requires the activation of host-cell signaling pathways in order to promote viral replication processes.
DuShane, Jeanne K. +4 more
openaire +3 more sources
The human
APMIS, 2013 JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964, PyV particles were revealed by electron microscopy in progressive multifocal leukoencephalopathy (PML) tissues. JCPyV infection is common in 35–70% of the general population, and the virus thereafter persists in the renourinary tract.
Hirsch, H. H. +3 more
openaire +5 more sources
Polyomavirus JCPyV infrequently detectable in adenoid cystic carcinoma of the oral cavity and the airways [PDF]
Virchows Archiv, 2019 Our objective was to assess the presence of three polyomaviruses, namely SV40, JCPyV, and BKPyV, and human papillomaviruses (HPV) in adenoid cystic carcinomas (ACC) of the minor salivary glands (MiSG) in the head and neck region. The study comprised 68 MiSG ACC patients operated during 1974-2012 at the Helsinki University Hospital (Helsinki, Finland ...
Hämetoja, Hanna +5 more
core +9 more sources