Induction of Brain Tumors by the Archetype Strain of Human Neurotropic JCPyV in a Transgenic Mouse Model [PDF]
Viruses, 2021 JC Virus (JCPyV), a member of the Polyomaviridiæ family, is a human neurotropic virus with world-wide distribution. JCPyV is the established opportunistic infectious agent of progressive multifocal leukoencephalopathy, a fatal demyelinating disease ...
Kamel Khalili +2 more
exaly +5 more sources
IFNα and β Mediated JCPyV Suppression through C/EBPβ-LIP Isoform [PDF]
Viruses, 2021 Polyomavirus JC (JCPyV) causes the demyelinating disease progressive multifocal leukoencephalopathy (PML). JCPyV infection is very common in childhood and, under conditions of severe immunosuppression, JCPyV may reactivate to cause PML. JC viral proteins
Dana May +5 more
doaj +3 more sources
The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes [PDF]
Viruses, 2021 JC polyomavirus (JCPyV) is a neuroinvasive pathogen causing a fatal, demyelinating disease of the central nervous system (CNS) known as progressive multifocal leukoencephalopathy (PML).
Michael P. Wilczek +6 more
doaj +3 more sources
Specific and quantitative detection of Human polyomaviruses BKPyV and JCPyV in the healthy Pakistani population [PDF]
Virology Journal, 2017 Background The BK Polyomavirus (BKPyV) and JC polyomavirus (JCPyV) infections are widespread in human population and have been associated with severe kidney and brain disorders, respectively.
Iqra Hussain +6 more
doaj +4 more sources
PI3K/AKT/mTOR Signaling Pathway Is Required for JCPyV Infection in Primary Astrocytes [PDF]
Cells, 2021 Astrocytes are a main target of JC polyomavirus (JCPyV) in the central nervous system (CNS), where the destruction of these cells, along with oligodendrocytes, leads to the fatal disease progressive multifocal leukoencephalopathy (PML).
Michael P. Wilczek +4 more
doaj +3 more sources
A study on the distribution of BK and JC polyomavirus in discarded donor kidneys [PDF]
Frontiers in TransplantationIntroductionBK polyomavirus (BKPyV) and JC polyomavirus (JCPyV) are thought to establish persistent, low-grade infections in the kidney. However, their specific intrarenal reservoirs remain unclear.
Wouter T. Moest +15 more
doaj +2 more sources
Divergent Trends of Anti-JCPyV Serum Reactivity and Neutralizing Activity in Multiple Sclerosis (MS) Patients during Treatment with Natalizumab [PDF]
Viruses, 2016 The association between natalizumab and progressive multifocal leukoencephalopathy (PML) is established, but a reliable clinical risk stratification flow-chart is lacking. New risk factors are needed, such as the possible role of the anti-JC polyomavirus
Roberta Antonia Diotti +9 more
doaj +4 more sources
Beyond Human Papillomavirus (HPV): Detection of EBV and Polyomaviruses in Cervical and Anal Samples. [PDF]
J Med VirolABSTRACT Colorectal and cervical cancers represent an important public health problem worldwide, particularly in Brazil. Colorectal cancer is one of the most frequently diagnosed malignancies worldwide and the most common cancer in both men and woman in Brazil.
Guimarães ACS +11 more
europepmc +2 more sources
Scientific Reports, 2023 BK (BKPyV) and JC (JCPyV) polyomavirus infections are commonly subclinical and known infrequently to cause serious clinical diseases. Longitudinal follow-up studies regarding JCPyV and BKPyV serological outcomes are scanty.
Hanna K. Laine +5 more
doaj +1 more source
Archetype JC Polyomavirus (JCPyV) Prevails in a Rare Case of JCPyV Nephropathy and in Stable Renal Transplant Recipients With JCPyV Viruria [PDF]
The Journal of Infectious Diseases, 2017 JC polyomavirus (JCPyV) is reactivated in approximately 20% of renal transplant recipients, and it may rarely cause JCPyV-associated nephropathy (JCPyVAN). Whereas progressive multifocal leukoencephalopathy of the brain is caused by rearranged neurotropic JCPyV, little is known about viral sequence variation in JCPyVAN owing to the rarity of this ...
Auvinen Eeva +15 more
openaire +2 more sources