Results 31 to 40 of about 1,015 (152)

The oncogenic roles of JC polyomavirus in cancer

Frontiers in Oncology, 2022
JC polyomavirus (JCPyV) belongs to the human polyomavirus family. Based on alternative splicing, the early region encodes the large and small T antigens, while the late region encodes the capsid structural proteins (VP1, VP2, and VP3) and the agnoprotein.
Hua-chuan Zheng, Hang Xue, Cong-yu Zhang
doaj   +1 more source

High-level JCPyV viruria after kidney transplantation—Clinical and histopathological findings [PDF]

Journal of Clinical Virology, 2016
The significance of JC polyomavirus (JCPyV) after kidney transplantation ranges from irrelevant to full-blown nephropathy or PML.To investigate the clinical significance of high-level JCPyV viruria and JCPyV primary infections after kidney transplantation.JCPyV viruria was detected in routine screening by quantitative real-time PCR in 40/238 kidney ...
Helantera, I., Hirsch, H. H., Auvinen, E., Mannonen, L., Nummi, M., Wernli, M., Ortiz, F., Raisanen-Sokolowski, A., Lempinen, M., Lautenschlager, I.   +9 more
openaire   +5 more sources

The human JC polyomavirus (JCPyV): virological background and clinical implications [PDF]

APMIS, 2013
JC polyomavirus (JCPyV) was the first of now 12 PyVs detected in humans, when in 1964, PyV particles were revealed by electron microscopy in progressive multifocal leukoencephalopathy (PML) tissues. JCPyV infection is common in 35–70% of the general population, and the virus thereafter persists in the renourinary tract.
Hirsch, H. H., Kardas, P., Kranz, D., Leboeuf, C.   +3 more
openaire   +4 more sources

JC Polyomavirus Infection of Primary Human Renal Epithelial Cells Is Controlled by a Type I IFN-Induced Response

mBio, 2016
The JC and BK human polyomaviruses (JCPyV and BKPyV, respectively) establish lifelong persistent infections in the kidney. In immunosuppressed individuals, JCPyV causes progressive multifocal leukoencephalopathy (PML), a fatal neurodegenerative disease ...
Benedetta Assetta, Marco De Cecco, Bethany O’Hara, Walter J. Atwood   +3 more
doaj   +1 more source

Unusually high incidence of polyomavirus JC infection in the higher grade of colorectal cancer tissues in Taiwan

European Journal of Medical Research, 2022
Introduction The human JC polyomavirus (JCPyV) has been detected in colorectal cancer (CRC) tissues and is suggested to contribute to CRC tumorigenesis. The rearrangement of the JCPyV regulatory region is supposedly associated with CRC development.
Chuan-Yin Fang, San-Yuan Chen, Bo-Xiu Hsiao, Hsin-Yi Huang, Yi-Ju Chen, Chun-Liang Tung, Chiung-Yao Fang   +6 more
doaj   +1 more source

Polyomavirus JCPyV infrequently detectable in adenoid cystic carcinoma of the oral cavity and the airways [PDF]

Virchows Archiv, 2019
Our objective was to assess the presence of three polyomaviruses, namely SV40, JCPyV, and BKPyV, and human papillomaviruses (HPV) in adenoid cystic carcinomas (ACC) of the minor salivary glands (MiSG) in the head and neck region. The study comprised 68 MiSG ACC patients operated during 1974-2012 at the Helsinki University Hospital (Helsinki, Finland ...
Hämetoja, Hanna, Hagström, Jaana, Haglund, Caj, Bäck, Leif, Mäkitie, Antti, Syrjänen, Stina   +5 more
openaire   +5 more sources

Detection and analysis of variants of JC polyomavirus in urine samples from HIV-1-infected patients in China’s Zhejiang Province

Journal of International Medical Research, 2018
Objectives Human JC polyomavirus (JCPyV) infection has an increased risk of developing progressive multifocal leukoencephalopathy (PML). Different JCPyV subtypes differ in the virulence with which they cause PML. Currently, the JCPyV infection status and
Caiqin Hu, Ying Huang, Junwei Su, Mengyan Wang, Qihui Zhou, Biao Zhu   +5 more
doaj   +1 more source

Traces of JC polyomavirus in papillary thyroid cancer: a comprehensive study in Iran

Virology Journal, 2022
Background JC polyomavirus (JCPyV) is known to induce solid tumors such as astrocytomas, glioblastomas, and neuroblastomas in experimental animals, and recent studies have shown that the virus may be correlated with carcinogenesis.
Amir Ali Karimi, Rahil Tarharoudi, Zahra Kianmehr, Fatemeh Sakhaee, Fatemeh Rahimi Jamnani, Seyed Davar Siadat, Abolfazl Fateh   +6 more
doaj   +1 more source

Comprehensive proteomic analysis of JC polyomavirus-infected human astrocytes and their extracellular vesicles

Microbiology Spectrum, 2023
JC polyomavirus (JCPyV) is an opportunistic virus that remains in a latent state in the kidneys and lymphoid organs of more than half of the human adult population.
Larise Oberholster, Amandine Mathias, Sylvain Perriot, Emma Blaser, Mathieu Canales, Samuel Jones, Lucas Culebras, Marie Gimenez, G. Campbell Kaynor, Alexey Sapozhnik, Kevin Richetin, Susan Goelz, Renaud Du Pasquier   +12 more
doaj   +1 more source

The presence of human polyomavirus JC (JCPyV) in pediatric brain tumors: a plausible trigger in Wnt/β-catenin pathway. [PDF]

J Neurovirol
Abstract JC polyomavirus (JCPyV) is associated with progressive multifocal leukoencephalopathy (PML), but its plausible role in brain cancers is also disputed. One candidate to mediate cell transformation is the Large T antigen (LTAg), which has the capability to bind the Wnt pathway protein β-catenin, thus ...
Passerini S, Messina S, De Angelis M, Nencioni L, Gianno F, Antonelli M, Pietropaolo V.   +6 more
europepmc   +3 more sources