Results 121 to 130 of about 5,535 (193)

Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection

Cell Death Discovery
Breast cancer is the leading cause of cancer-related deaths in women worldwide, with the basal-like or triple-negative breast cancer (TNBC) subtype being particularly aggressive and challenging to treat. Understanding the molecular mechanisms driving the
Tirza Bidany-Mizrahi, Aya Shweiki, Kian Maroun, Lina Abu-Tair, Bella Mali, Rami I. Aqeilan   +5 more
doaj   +1 more source

A novel approach to simultaneously scan genes at fragile sites

BMC Cancer, 2006
Background Fragile sites are regions of the genome sensitive to replication stress and to exposure to environmental carcinogens. The two most commonly expressed fragile sites FRA3B and FRA16D host the histidine triad (FHIT) and WW domain containing ...
Brown Jacqueline, Willem Pascale, Schouten Jan   +2 more
doaj   +1 more source

The function and mechanism of ENO1 in glioma cell model [PDF]

, 2016
神经胶质瘤是一种发生在脑和脊髓的胶质细胞癌变的肿瘤。胶质瘤占脑和中枢系统肿瘤的30%，占脑恶性肿瘤的80%，年发病率约为3-8人/10万人口。ENO1是糖酵解中催化磷酸烯醇式丙酮酸和磷酸甘油酸相互转化的限速酶，在多种肿瘤中，ENO1表达水平均上调。 本研究通过对以WBP2为诱饵的pull-down/MS结果分析得到ENO1为可能与WBP2相互作用的蛋白质。体外表达并纯化了ENO1蛋白质，并通过Pull-down实验证实了ENO1和WBP2间存在相互作用，即二者能够在体外结合 ...
李芳芳
core  

Integrating bulk RNA-seq and scRNA-seq data to explore diverse cell death patterns and develop a programmed cell death-related relapse prediction model in pediatric B-ALL

Scientific Reports
Acute B-lymphoblastic leukemia (B-ALL) is a hematologic malignancy with diverse mechanisms of PCD influencing its progression. This study aimed to identify PCD-related biomarkers and develop a predictive model for relapse in pediatric B-ALL patients ...
Yaxin Luo, Lin Tan, Chuikai Meng, Jingyu Gao, Hongxin Chen, Ruihan Fang, Xuedong Wu   +6 more
doaj   +1 more source

Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease [PDF]

, 2018
We review the putative functions and malfunctions of proteins encoded by genes mutated in Charcot-Marie-Tooth disease (CMT; inherited motor and sensory neuropathies) in normal and affected peripheral nerves. Some proteins implicated in demyelinating CMT,
Berger, Philipp, Niemann, Axel, Suter, Ueli   +2 more
core  

WW Domain-Containing Oxidoreductase [PDF]

, 2020
openaire   +1 more source

Down-regulation of WW Domain-containing Oxidoreductase Induces Tau Phosphorylation in Vitro [PDF]

Journal of Biological Chemistry, 2004
Chun-I Sze, Meng Su, Subbiah Pugazhenthi, Purevsuren Jambal, Li-Jin Hsu, John Heath, Lori Schultz, Nan-Shan Chang   +7 more
openaire   +1 more source

The role of WW domain-containing oxidoreductase in lymphocyte development

Frontiers in Immunology, 2013
Jui Yen, Lo, Li-Jin, Hsu
openaire   +1 more source

WWOX promotes osteosarcoma development via upregulation of Myc

Cell Death and Disease
Osteosarcoma is an aggressive bone tumor that primarily affects children and adolescents. This malignancy is highly aggressive, associated with poor clinical outcomes, and primarily metastasizes to the lungs.
Rania Akkawi, Osama Hidmi, Ameen Haj-Yahia, Jonathon Monin, Judith Diment, Yotam Drier, Gary S. Stein, Rami I. Aqeilan   +7 more
doaj   +1 more source

Dissociation of the nuclear WWOX/TRAF2 switch renders UV/cold shock-mediated nuclear bubbling cell death at low temperatures

Cell Communication and Signaling
Background Normal cells express functional tumor suppressor WW domain-containing oxidoreductase (WWOX), designated WWOXf. UV irradiation induces WWOXf cells to undergo bubbling cell death (BCD) — an event due to the accumulation of nuclear nitric oxide ...
Szu-Jung Chen, Cheng-Chang Tsai, Sing-Ru Lin, Ming-Hui Lee, Shenq-Shyang Huang, Han-Yan Zeng, Lu-Hai Wang, Ming-Fu Chiang, Hamm-Ming Sheu, Nan-Shan Chang   +9 more
doaj   +1 more source