WW-Domain Containing Protein Roles in Breast Tumorigenesis [PDF]
Frontiers in Oncology, 2018 Protein-protein interactions are key factors in executing protein function. These interactions are mediated through different protein domains or modules. An important domain found in many different types of proteins is WW domain.
Abrar Jamous, Zaidoun Salah
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The WW domain presents a promising target for the development of PCIF1 agonists in the treatment of glioma [PDF]
npj Precision OncologyPCIF1 is currently the sole m6Am methyltransferase in mammalian mRNA, but it was initially named for the interaction between its WW domain and RNA polymerase II.
Jiale Yin +9 more
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Decoding WW domain tandem-mediated target recognitions in tissue growth and cell polarity [PDF]
eLife, 2019 WW domain tandem-containing proteins such as KIBRA, YAP, and MAGI play critical roles in cell growth and polarity via binding to and positioning target proteins in specific subcellular regions. An immense disparity exists between promiscuity of WW domain-
Zhijie Lin +5 more
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WW Domain-Containing E3 Ubiquitin Protein Ligase 1: A Self-Disciplined Oncoprotein [PDF]
Frontiers in Cell and Developmental Biology, 2021 WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) is a member of C2-WW-HECT E3 ligase family. Although it may execute carcinostatic actions in some scenarios, WWP1 functions as an oncoprotein under most circumstances.
Linghan Kuang +5 more
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Functional role of WW domain‐containing proteins in tumor biology and diseases: Insight into the role in ubiquitin‐proteasome system [PDF]
FASEB BioAdvances, 2020 The ubiquitin‐proteasome system (UPS) governs the protein degradation process and balances proteostasis and cellular homeostasis. It is a well‐controlled mechanism, in which removal of the damaged or excessive proteins is essential in driving signal ...
Shenq‐Shyang Huang +2 more
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Structural Insights into the Protein Mannosyltransferase from Mycobacterium tuberculosis reveal a WW-Domain-Like Protein Motif in Bacteria [PDF]
Communications BiologyWe have previously demonstrated that protein-O-mannosylation (POM), a widespread post-translational glycosyl modification of proteins, is a key virulence factor of Mycobacterium tuberculosis (Mtb), the world’s deadliest infectious agent.
Nicolas Géraud +10 more
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Nuclear Condensates of WW Domain‐Containing Adaptor With Coiled‐Coil Regulate Mitophagy via Alternative Splicing [PDF]
Advanced ScienceBiomolecular condensates segregate nuclei into discrete regions, facilitating the execution of distinct biological functions. Here, it is identified that the WW domain containing adaptor with coiled‐coil (WAC) is localized to nuclear speckles via its WW ...
Jiahe Wang +13 more
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Cancerous Protein Network That Inhibits the Tumor Suppressor Function of WW Domain-Containing Oxidoreductase (WWOX) by Aberrantly Expressed Molecules [PDF]
Frontiers in Oncology, 2018 Recent findings indicate that the WW domain-containing oxidoreductase (WWOX) is a tumor suppressor protein that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. WWOX protein mediates multiple signaling networks
Chiemi Saigo +2 more
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WW domain-binding protein 2 overexpression prevents diet-induced liver steatosis and insulin resistance through AMPKβ1 [PDF]
Cell Death and Disease, 2021 Nonalcoholic fatty liver disease (NAFLD) is prevalent clinically and can lead to more serious chronic liver disease. However, the pathological mechanism is still unclear, and thus, there are no approved drugs on the market. Transcriptional coactivator WW
Zhe Zheng +7 more
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Docking analysis of verteporfin with YAP WW domain. [PDF]
Bioinformation, 2017 The YAP oncogene is a known cancer target. Therefore, it is of interest to understand the molecular docking interaction of verteporfin (a derivative of benzo-porphyrin) with the WW domain of YAP (clinically used for photo-dynamic therapy in macular degeneration) as a potential WW domain-ligand modulator by inhibition.
Kandoussi I +3 more
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