Central role of Yes-associated protein and WW-domain-containing transcriptional co-activator with PDZ-binding motif in pancreatic cancer development. [PDF]
World J Gastroenterol, 2019 Pancreatic ductal adenocarcinoma (PDAC) remains a deadly disease with no efficacious treatment options. PDAC incidence is projected to increase, which may be caused at least partially by the obesity epidemic.
Rozengurt E, Eibl G.
europepmc +3 more sources
Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders [PDF]
Frontiers in Oncology, 2019 Nan-Shan Chang +3 more
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Structure, 1996 WW domains are recently described protein-protein interaction modules; they bind to proline-rich sequences that usually also contain a tyrosine. These domains have been detected in several unrelated proteins, often alongside other domains. Recent studies suggest that WW domains in specific proteins may play a role in diseases such as hypertension or ...
Staub, Olivier, Rotin, Daniela
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WW domains of the yes-kinase-associated-protein (YAP) transcriptional regulator behave as independent units with different binding preferences for PPxY motif-containing ligands. [PDF]
PLoS ONE, 2015 YAP is a WW domain-containing effector of the Hippo tumor suppressor pathway, and the object of heightened interest as a potent oncogene and stemness factor. YAP has two major isoforms that differ in the number of WW domains they harbor.
Manuel Iglesias-Bexiga +5 more
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Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. [PDF]
PLoS Pathogens, 2017 Ebola (EBOV) and Marburg (MARV) viruses are members of the Filoviridae family which cause outbreaks of hemorrhagic fever. The filovirus VP40 matrix protein is essential for virus assembly and budding, and its PPxY L-domain motif interacts with WW-domains
Jingjing Liang +6 more
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Frontiers in Cell and Developmental Biology, 2021 PLEKHA5, PLEKHA6, and PLEKHA7 (WW-PLEKHAs) are members of the PLEKHA family of proteins that interact with PDZD11 through their tandem WW domains.
Sophie Sluysmans +3 more
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WW domain sequence activity relationships identified using ligand recognition propensities of 42 WW domains [PDF]
Protein Science, 2003 AbstractWW domains mediate protein–protein interactions in a number of different cellular functions by recognizing proline‐containing peptide sequences. We determined peptide recognition propensities for 42 WW domains using NMR spectroscopy and peptide library screens. As potential ligands, we studied both model peptides and peptides based on naturally
Otte, Livia +9 more
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Dominant folding pathways of a WW domain [PDF]
Proceedings of the National Academy of Sciences, 2012 We investigate the folding mechanism of the WW domain Fip35 using a realistic atomistic force field by applying the Dominant Reaction Pathways approach. We find evidence for the existence of two folding pathways, which differ by the order of formation of the two hairpins.
S. a. Beccara +3 more
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WW or WoW: The WW domains in a union of bliss [PDF]
IUBMB Life (International Union of Biochemistry and Molecular Biology: Life), 2005 WW domains are small protein modules that recognize proline-rich peptide motifs or phosphorylated-serine/threonine proline sites in cognate proteins. Within host proteins these modules are joined to other protein domains or to a variety of catalytic domains acting together as adaptors or targeting anchors of enzymes. An important aspect of signaling by
Marius, Sudol +4 more
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WWOX (WW domain containing oxidoreductase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008 Review on WWOX (WW domain containing oxidoreductase), with data on DNA, on the protein encoded, and where the gene is implicated.
Druck, Teresa +2 more
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