Results 31 to 40 of about 169,270 (280)
A course space construction based on local Dirichlet-to-Neumann maps [PDF]
, 2011 Coarse-grid correction is a key ingredient of scalable domain decomposition methods. In this work we construct coarse-grid space using the low-frequency modes of the subdomain Dirichlet-to-Neumann maps and apply the obtained two-level preconditioners to ...
Dohrmann C. R. +4 more
core +4 more sources
Structure–function–folding relationship in a WW domain [PDF]
Proceedings of the National Academy of Sciences, 2006 Protein folding barriers result from a combination of factors including unavoidable energetic frustration from nonnative interactions, natural variation and selection of the amino acid sequence for function, and/or selection pressure against aggregation. The rate-limiting step for human Pin1 WW domain folding is the formation of the loop 1 substructure.
Marcus, Jäger +8 more
openaire +2 more sources
SIMPLE/LITAF expression induces the translocation of the ubiquitin ligase itch towards the lysosomal compartments. [PDF]
PLoS ONE, 2011 LITAF is a small cellular protein with an unknown function. The C-terminus of LITAF contains a highly conserved domain termed the SIMPLE-like domain (SLD), while the N-terminus contains two PPXY motifs that mediate protein-protein interactions with WW ...
Heather E Eaton +5 more
doaj +1 more source
Balancing domain decomposition by constraints and perturbation [PDF]
, 2016 In this paper, we formulate and analyze a perturbed formulation of the balancing domain decomposition by constraints (BDDC) method. We prove that the perturbed BDDC has the same polylogarithmic bound for the condition number as the standard formulation ...
Badia, Santiago, Nguyen, Hieu Trung
core +3 more sources
WW Domain Folding Complexity Revealed by Infrared Spectroscopy [PDF]
Biochemistry, 2014 Although the intrinsic tryptophan fluorescence of proteins offers a convenient probe of protein folding, interpretation of the fluorescence spectrum is often difficult because it is sensitive to both global and local changes. Infrared (IR) spectroscopy offers a complementary measure of structural changes involved in protein folding, because it probes ...
Davis, Caitlin M., Dyer, R. Brian
openaire +2 more sources
Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress
Diseases, 2018 Lassa fever virus (LFV) belongs to the Arenaviridae family and can cause acute hemorrhagic fever in humans. The LFV Z protein plays a central role in virion assembly and egress, such that independent expression of LFV Z leads to the production of virus ...
Ziying Han +11 more
doaj +1 more source
WW domain-containing oxidoreductase-related epileptic encephalopathy in Two Omani Children.
Journal of Biochemical and Clinical Genetics, 2023 Background: Autosomal recessive developmental and epileptic encephalopathy type 28 (DEE28) is a rare genetic disorder that affects children in the early months of life.
Moosa Al-Lawati +7 more
doaj +1 more source
Identification and stage-specific association with the translational apparatus of TbZFP3, a CCCH protein that promotes trypanosome life-cycle development [PDF]
, 2006 The post-transcriptional control of gene expression is becoming increasingly important in the understanding of regulated events in eukaryotic cells. The parasitic kinetoplastids have a unique reliance on such processes, because their genome is organized ...
Athina Paterou +48 more
core +1 more source
Testing Simplified Proteins Models of the hPin1 WW Domain [PDF]
Biophysical Journal, 2006 The WW domain of the human Pin1 protein for its simple topology and the large amount of experimental data is an ideal candidate to assess theoretical approaches to protein folding. The purpose of the present work is to compare the reliability of the chemically-based Sorenson/Head-Gordon (SHG) model and a standard native centric model in reproducing ...
F. CECCONI, C. GUARDIANI, LIVI, ROBERTO
openaire +7 more sources
NOD2 and inflammation: current insights [PDF]
, 2018 The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan and promotes their clearance through activation of a proinflammatory ...
Cucchiara, Salvatore +3 more
core +2 more sources