Results 41 to 50 of about 169,270 (280)
Control of tissue growth and cell transformation by the Salvador/Warts/Hippo pathway.
PLoS ONE, 2012 The Salvador-Warts-Hippo (SWH) pathway is an important regulator of tissue growth that is frequently subverted in human cancer. The key oncoprotein of the SWH pathway is the transcriptional co-activator, Yes-associated protein (YAP).
Xiaomeng Zhang +2 more
doaj +1 more source
Cell Death and Disease, 2021 WW domain binding protein-2 (WBP2) can function as a Yes-associated protein/transcriptional co-activator with PDZ-binding motif (YAP/TAZ) co-activator and has a crucial role in promoting breast cancer progression.
Qiang Han +6 more
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Minimax frequency domain performance and robustness optimization of linear feedback systems [PDF]
, 1985 It is shown that feedback system design objectives, such as disturbance attenuation and rejection, power and bandwidth limitation, and robustness, may be expressed in terms of required bounds of the sensitivity function and its complement on the ...
Kwakernaak, Huibert
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Versatile communication strategies among tandem WW domain repeats [PDF]
Experimental Biology and Medicine, 2015 Interactions mediated by short linear motifs in proteins play major roles in regulation of cellular homeostasis since their transient nature allows for easy modulation. We are still far from a full understanding and appreciation of the complex regulation patterns that can be, and are, achieved by this type of interaction.
E. J. Dodson +3 more
openaire +2 more sources
Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]
, 2014 BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo +8 more
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A de novo redesign of the WW domain [PDF]
Protein Science, 2003 AbstractWe have used a sequence prediction algorithm and a novel sampling method to design protein sequences for the WW domain, a small β‐sheet motif. The procedure, referred to as SPANS, designs sequences to be compatible with an ensemble of closely related polypeptide backbones, mimicking the inherent flexibility of proteins.
Christina M, Kraemer-Pecore +2 more
openaire +2 more sources
PLoS Pathogens, 2020 Ebola (EBOV) and Marburg (MARV) are members of the Filoviridae family, which continue to emerge and cause sporadic outbreaks of hemorrhagic fever with high mortality rates.
Ziying Han +14 more
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A PDE-constrained optimization formulation for discrete fracture network flows [PDF]
, 2013 We investigate a new numerical approach for the computation of the 3D flow in a discrete fracture network that does not require a conforming discretization of partial differential equations on complex 3D systems of planar fractures.
Cacas M. C. +4 more
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Molecular mechanisms underlying the evolution of the slp76 signalosome
Scientific Reports, 2017 The well-defined mammalian slp76-signalosome is crucial for T-cell immune response, yet whether slp76-signalosome exists in invertebrates and how it evolved remain unknown.
Xuemei Qu +6 more
doaj +1 more source
Downhill versus two-state protein folding in a statistical mechanical model
, 2007 The authors address the problem of downhill protein folding in the framework of a simple statistical mechanical model, which allows an exact solution for the equilibrium and a semianalytical treatment of the kinetics.
Bruscolini, P. +2 more
core +1 more source