Results 61 to 70 of about 169,270 (280)

Gears-In-Motion: The Interplay of WW and PPIase Domains in Pin1

open access: yesFrontiers in Oncology, 2018
Pin1 belongs to the family of the peptidyl-prolyl cis-trans isomerase (PPIase), which is a class of enzymes that catalyze the cis/trans isomerization of the Proline residue. Pin1 is unique and only catalyzes the phosphorylated Serine/Threonine-Proline (S/
Yew Mun Lee, Yih-Cherng Liou
doaj   +1 more source

Effectiveness of rTMS on Working Memory and Inhibitory Impairments in Patients With Post‐Stroke Executive Deficits

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Considerable efforts have been dedicated to developing effective treatments for post‐stroke executive impairment (PSEI), among which repetitive transcranial magnetic stimulation (rTMS) has shown great potential. This study aimed to investigate the therapeutic effects of high‐frequency rTMS on working memory (WM) and response ...
Mengting Lao   +6 more
wiley   +1 more source

A Novel Scheme for Quantitative Electromagnetic Inversion of Non-Cooperative Translational Targets Under Limited-Aperture Scenarios

open access: yesSensors
To achieve accurate localization and tackle the inevitable dual challenges of ill-posedness and strong nonlinearity in limited-aperture translational target inversion, this paper proposes a novel integrated scheme that synergistically combines a domain ...
Yitao Lin   +4 more
doaj   +1 more source

Smurf2 suppresses the metastasis of hepatocellular carcinoma via ubiquitin degradation of Smad2

open access: yesOpen Medicine, 2022
Smurf2, one of C2-WW-HECT domain E3 ubiquitin ligases, is closely related to the development and progression in different cancer types, including hepatocellular carcinoma (HCC).
Song Dongqiang   +4 more
doaj   +1 more source

The Renal Activity Index for Lupus Identifies Active Renal Disease and Treatment Response in Adult Patients With Systemic Lupus Erythematosus and Lupus Nephritis

open access: yesArthritis Care &Research, EarlyView.
Objective We evaluated the ability of the Renal Activity Index for Lupus (RAIL) to discriminate active lupus nephritis (LN) in adult patients with active systemic lupus erythematosus (SLE) and differentiate LN treatment response. Methods Urine samples from adults with biopsy‐proven active class III and IV LN from TULIP‐LN (active LN group ...
Hermine I. Brunner   +12 more
wiley   +1 more source

Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain

open access: yesCommunications Biology, 2021
In order to advance our understanding of the regulation of Ubiquitin-specific protease 8 (USP8), which is known to play a role in Cushing’s Disease, Kakihara et al identify and characterise amino acids 645–684 of USP8, which serve as an autoinhibitory ...
Keijun Kakihara   +10 more
doaj   +1 more source

The Dominant Negative IQGAP1(IR-WW) Domain as a Potential Therapy in Brain Cancer

open access: yesTranslation, 2023
Please view the PDF to see the formatted meeting abstract.  
Mahasin Osman
doaj   +1 more source

Cumulative Social Disadvantage and Disease Activity in Juvenile Idiopathic Arthritis: A Childhood Arthritis and Rheumatology Research Alliance Registry Study

open access: yesArthritis Care &Research, EarlyView.
Objective Social determinants of health (SDOH) contribute to juvenile idiopathic arthritis (JIA) disparities, but most studies have assessed SDOH independently rather than cumulatively across individual, family, and neighborhood levels. Using a socioecological framework, we investigated the relationship among cumulative social disadvantage ...
William Daniel Soulsby   +448 more
wiley   +1 more source

Maize open-pollinated populations physiological improvement: validating tools for drought response participatory selection [PDF]

open access: yes, 2019
Participatory selection—exploiting specific adaptation traits to target environments—helps to guarantees yield stability in a changing climate, in particular under low-input or organic production.
Araus   +25 more
core   +2 more sources

WW domain-containing FBP-30 is regulated by p53 [PDF]

open access: yesCell Death & Differentiation, 1999
A subtractive cloning approach was used to clone genes transcriptionally induced in thymocytes undergoing programmed cell death after gamma-irradiation. We thus identified about 60 upregulated genes. One of these genes encodes a WW domain previously briefly reported by others, which defines this gene as FBP-30.
V, Depraetere, P, Golstein
openaire   +2 more sources

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