Results 101 to 110 of about 6,450 (234)
Epilepsia Open, Volume 10, Issue 4, Page 1065-1073, August 2025.Abstract Objective Genetic testing is now included in the diagnostic assessment of childhood onset epilepsies. We evaluated the yield of a targeted next generation sequencing (TNGS) panel dedicated to pediatric epilepsies. Methods We tested by TNGS panel 1000 consecutive patients presenting with childhood onset epilepsies and including mainly patients ...
Giulia Barcia +21 more
wiley +1 more source
The role of AP-2 alpha in predicting response to chemotherapy in breast cancer patients [PDF]
, 2011 Breast cancer is the most frequent cancer occurring in women in Europe1. In Switzerland, the incidence in 2009 was 32,9% and it was the primary cause of cancer related death in women, with a mortality rate of 19.2%2. The management of this cancer depends
SICHITIU, J.
core
Role of NTRK Fusion Genes in the Tumor Immune Microenvironment of HPV (+/−) Cervical Cancer
Journal of Medical Virology, Volume 97, Issue 8, August 2025.ABSTRACT Cervical cancer, a prevalent gynecological malignancy, is primarily associated with human papillomavirus (HPV) infection. However, some cases display distinct molecular alterations beyond HPV, significantly impacting the tumor immune microenvironment (TIME) and posing therapeutic challenges.
Qiongying Wang +7 more
wiley +1 more source
Loss of lung WWOX expression causes neutrophilic inflammation [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2017 The tumor suppressor WW domain-containing oxidoreductase (WWOX) exhibits regulatory interactions with an array of transcription factors and signaling molecules that are positioned at the well-known crossroads between inflammation and cancer. WWOX is also subject to downregulation by genotoxic environmental exposures, making it of potential interest to ...
Sunit, Singla +6 more
openaire +2 more sources
Cellular Physiology and Biochemistry, 2014 Background: Extrahepatic cholangiocarcinoma (EHCC) is the second most common primary hepatic malignancy, and is associated with high morbidity and mortality.
Mei Wang +5 more
doaj +1 more source
Insight into the pathogenesis and nature of Central giant cell lesions of the jaws [PDF]
, 2015 Central giant cell lesions of the jaws are not uncommon. While the majority of these represent single, sporadic lesions, histologically identical lesions are seen in association with a number of other bone lesions, as well as in certain syndromes. This
Edwards, Paul Charles
core +3 more sources
The WWOX/HIF1A Axis Downregulation Alters Glucose Metabolism and Predispose to Metabolic Disorders [PDF]
, 2022 Izabela Baryła +4 more
openalex +1 more source
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, Volume 45, Issue 8, Page 476-485, August 2025.Abstract Objectives Second‐generation antipsychotic (SGA) medications are frequently prescribed for mental health conditions; however, they are associated with an increased risk of metabolic syndrome (MetS). We aimed to identify genetic associations of SGA‐associated MetS (SGA–MetS) using genome‐wide approaches within the UK Biobank. We also set out to
Nihal El Rouby +11 more
wiley +1 more source
Frontiers in Oncology, 2018 Recent findings indicate that the WW domain-containing oxidoreductase (WWOX) is a tumor suppressor protein that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. WWOX protein mediates multiple signaling networks
Chiemi Saigo +2 more
doaj +1 more source
A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets [PDF]
, 2012 Objective: Gastric cancer is a major gastrointestinal malignancy for which targeted therapies are emerging as treatment options. This study sought to identify the most prevalent molecular targets in gastric cancer and to elucidate systematic patterns of ...
Bell, S +28 more
core +2 more sources