Results 81 to 90 of about 1,108 (158)

WWOX in brain development and disease: Molecular mechanisms and therapeutic opportunities

Neurobiology of Disease
The WW domain–containing oxidoreductase (WWOX) gene, located at the common fragile site FRA16D, has emerged as a key molecular link between genome instability and nervous system biology.
Mustafa Obeid, Jingkai Wang, Baraa Abudiab, Rania Akkawi, Rami I. Aqeilan   +4 more
doaj   +1 more source

Novel homozygous mutation in the WWOX gene causes seizures and global developmental delay: Report and review

Translational Neuroscience, 2018
The WWOX gene has a WW domain containing oxidoreductase, which is located at the common fragile site FRA16D at chromosome 16q23. WWOX is a tumor suppressor gene that has been associated with several types of cancer such as hepatic, breast, lung, prostate,
Ehaideb Salleh N., Al-Bu Ali Majed J., Al-obaid Jaafer J., Aljassim Kareemah M., Alfadhel Majid   +4 more
doaj   +1 more source

Toosendanin Alleviates Cerebral Ischemia/Reperfusion Injury via Inhibiting Neural Ferroptosis Through Lipid Metabolic Reprogramming in MCAO Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
Post‐stroke administration of TSN significantly reduced infarct volume, neuroinflammation, and improved functional recovery of MCAO mice. TSN alleviated neural oxidative stress, lipid peroxidation, and ferroptosis in MCAO mice. TSN modulated the infiltration of immune cells in MCAO mice in vivo and T cell differentiation in vitro.
Xinyun Li, Zhiyong Zhao, Jingting Zhao, Xiangming Ye, Zhenfei Xiong, Jiejin Zhao   +5 more
wiley   +1 more source

Additional file 1: of A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

, 2019
Figure S1. Wild type MEF cells migrate collectively, whereas Wwox knockout MEF cells migrate individually. Shown is the imaging of cell migration at 0 and 48 h by time-lapse microscopy.
Nan-Shan Chang (76035), Lori Schultz (76032), Sing-Ru Lin (257489), Chun-I Sze (257501), Pei-Yi Chou (6991742), Ming-Hui Lee (257492)   +5 more
core   +1 more source

Exploring the Potential of Calebin‐A in Targeting Obesity‐Related Genes and Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Obesity is a global health crisis affecting millions, associated with metabolic disorders such as type 2 diabetes and cardiovascular disease. Calebin‐A, a bioactive compound derived from Curcuma species, has shown promise in managing obesity and its complications.
Ali Mahmoudi, Ali Saeedi‐Boroujeni, Sercan Karav, Prashant Kesharwani, Amirhossein Sahebkar   +4 more
wiley   +1 more source

Ectopic Egr/TNFα has no obvious effect on cytoplasmically localized WWOX.

, 2015
(A) Ectopic expression of GFP and WWOX in the posterior portion of wing discs of wandering third instar larvae (hh>GFP>WWOX), GFP shows the region of ectopic expression.
Cheng Shoou Lee (786444), Robert I. Richards (159264), Amanda Choo (786445), Louise V. O’Keefe (159252)   +3 more
core   +1 more source

Exosomal Non‐Coding RNAs in Gastrointestinal Cancer Drug Resistance: A Systematic Review of Emerging Mechanisms and Clinical Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak, Zahra Sadeghloo, Fateme Binayi, Stefania Nobili, Sara Ashtari, Amir Sadeghi, Nayeralsadat Fatemi   +6 more
wiley   +1 more source

Molecular alterations of the WWOX gene in nasopharyngeal carcinoma

Neoplasma, 2014
The WW domain-containing oxidoreductase (WWOX) gene is a candidate tumor suppressor gene. However, its exact mechanism is unclear. This study aimed to investigate the role of the WWOX gene in the development of nasopharyngeal carcinoma (NPC). Tissues were collected from 65 NPC patients.
Z, Yang, H, Lan, X, Chen, P, Li, S, Li, W, Mo, A, Tang   +6 more
openaire   +3 more sources

Hematolojik milignitelerde wwox’ ın prognostik öneminin araştırılması [PDF]

, 2019
WW alanı içeren oksidoredüktaz (WW domain-containing oxidoreductase, WWOX) geni kromozom 16q23.3-q24.1 bölgesinde bulunmaktadır ve yaygın kromozomal frajil bölge, FRA16D, içermektedir.
Hancı, Halil
core   +1 more source

Molecular Alterations in Osteosarcomas of the Oral and Maxillofacial Region: A Scoping Review

Journal of Oral Pathology &Medicine, Volume 55, Issue 4, Page 439-447, April 2026.
ABSTRACT Background Given the rarity and aggressive nature of osteosarcomas (OS) in the oral and maxillofacial region, understanding their molecular alterations is essential to improve diagnosis, prognosis, and guide targeted therapies. This study aimed to map molecular alterations associated with oral and maxillofacial OS, providing an overview of the
Iara Vieira Ferreira, Reydson Alcides de Lima‐Souza, Moisés Willian Aparecido Gonçalves, Carlos Takahiro Chone, Arthur Antolini‐Tavares, Albina Altemani, Fernanda Viviane Mariano   +6 more
wiley   +1 more source