Results 61 to 70 of about 1,108 (158)
Frontiers in Oncology, 2019 WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature of various B cell neoplasms such ...
Kevin M. McBride +8 more
doaj +1 more source
Alzheimer's &Dementia, Volume 22, Issue 10, October 2026.Abstract INTRODUCTION Novel tools for absolute quantification of established and emerging fluid neuro‐biomarkers are required to advance diagnostic studies and improve biological insights. METHODS We conducted an extensive analytical and clinical validation of the Olink™ Target 48 Neurodegeneration panel (T48 Neuropanel) in 352 paired cerebrospinal ...
Yanaika S. Hok‐A‐Hin +8 more
wiley +1 more source
Altered WWOX modifies ectopic Egr/TNFα-mediated eye phenotype.
, 2015 (A) Ectopic expression of Egr/TNFα (GMR>egr+w>empty vector (EV)) results in a decrease in eye size and disruption to ommatidial patterning. (B) The ectopic Egr/TNFα phenotype is completely suppressed by decreased levels of TNFR (GMR>egr+w>wengen/TNFR-IR).
Cheng Shoou Lee (786444) +3 more
core +1 more source
BMC Cancer, 2005 Background The putative tumor suppressor WWOX gene spans the common chromosomal fragile site 16D (FRA16D) at chromosome area 16q23.3-24.1. This region is a frequent target for loss of heterozygosity and chromosomal rearrangement in ovarian, breast ...
Liu Jinsong +10 more
doaj +1 more source
Movement Disorders in Developmental and Epileptic Encephalopathies
Movement Disorders Clinical Practice, Volume 13, Issue 10, Page 2328-2340, October 2026.Abstract Background Monogenic developmental and epileptic encephalopathies (DEE) frequently feature co‐occurring movement disorders. Gene discovery has expanded epilepsy‐dyskinesia syndromes (EDS) from classic associations such as stereotypies in Rett syndrome to PRRT2‐related infantile seizures with paroxysmal dyskinesia and crouched gait in SCN1A ...
Shekeeb Mohammad +2 more
wiley +1 more source
WWOX guards genome stability by activating ATM [PDF]
Molecular & Cellular Oncology, 2015 Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be "hot spots" for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates ...
Hazan, Idit +3 more
openaire +2 more sources
Quantitation of WWOX and phospho-WWOX levels in LNCaP cells.
, 2013 The amount of WWOX protein (in panel A) and phospho-WWOX protein (in panel B), are shown for LNCaP cells adjacent to HUVECs (in red) and those cells non-adjacent to HUVECs (in black).
Andrew Hill (95939) +5 more
core +1 more source
Epilepsia, Volume 67, Issue 9, Page 4536-4550, September 2026.Abstract Objective Developmental and epileptic encephalopathies (DEEs) are characterized by drug‐resistant seizures and developmental slowing/regression. We examined the efficacy and tolerability of fenfluramine (FFA) in pediatric and adult patients with Lennox–Gastaut syndrome (LGS), Dravet syndrome (DS), and other DEEs.
Vicente Villanueva +29 more
wiley +1 more source
WW domain-containing oxidoreductase-related epileptic encephalopathy in Two Omani Children.
Journal of Biochemical and Clinical Genetics, 2023 Background: Autosomal recessive developmental and epileptic encephalopathy type 28 (DEE28) is a rare genetic disorder that affects children in the early months of life.
Moosa Al-Lawati +7 more
doaj +1 more source
The WWOX Tumor Suppressor Is Essential for Postnatal Survival and Normal Bone Metabolism
, 2008 The WW domain-containing oxidoreductase (WWOX) gene encodes a tumor suppressor. We have previously shown that targeted ablation of the Wwox gene in mouse increases the incidence of spontaneous and chemically induced tumors.
Carlo M. Croce +24 more
core +2 more sources