Results 41 to 50 of about 1,108 (158)
The effects of protocadherin 8 and WWOX in prostate adenocarcinoma
Journal of Men's Health, 2022 Objective: The protocadherin 8 (PCDH8) gene, located on chromosome 13q14.3 encodes an integral membrane protein. WWOX (fragile site FRA16D oxido-reductase) is a tumor suppressor gene located in region 16q23.324.1. The aim of this study was to investigate
Mürüvvet Akçay Çelik +3 more
doaj +1 more source
LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX [PDF]
Cancer Biology & Therapy, 2020 Increasing evidence has revealed that long noncoding RNAs (lncRNAs) emerge as pivotal regulators in diverse cancers, including hepatocellular carcinoma (HCC). This study was conducted to investigate the role of lncRNA WWOX antisense RNA 1 (WWOX-AS1) in HCC progression.
Dafeng Xu +8 more
openaire +2 more sources
Cell Communication and Signaling, 2019 Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we investigated the formation of WWOX/TIAF1/p53 triad and its regulation of cancer cell ...
Pei-Yi Chou +5 more
doaj +1 more source
Tumor suppressive functions of WWOX.
, 2016 WWOX interacts with signaling molecules in the cytoplasm and prevents their entry to the nucleus to modulate their tumorigenic pathways. Upon stress such as ionizing radiation (IR), ultraviolet radiation (UV), or maybe even neuronal injury, WWOX enters ...
Thomas G. Hofmann (196333) +2 more
core +1 more source
Phosphorylation/de-phosphorylation in specific sites of tumor suppressor WWOX and control of distinct biological events [PDF]
, 2018 Abnormal differentiation and growth of hematopoietic stem cells cause the development of hematopoietic diseases and hematopoietic malignancies. However, the molecular events underlying leukemia development are not well understood.
Nan-Shan Chang +3 more
core +1 more source
Frontiers in Oncology, 2018 It has become clear from multiple studies that WWOX (WW domain-containing oxidoreductase) operates as a “non-classical” tumor suppressor of significant relevance in cancer progression.
Tabish Hussain +4 more
doaj +1 more source
Wwox mRNA expression in BK5-Cre model of Wwox deletion.
, 2012 qRT-PCR was used to determine the mRNA expression of Wwox in mammary epithelial organoids from BK5 Wwox WT and KO animals. The box plots show dramatically decreased Wwox mRNA levels in epithelium from 8 week virgin (A) and P18.5 days (B) Wwox KO mammary ...
Xinsheng Gao (167498) +6 more
core +1 more source
WWOX: a tumor suppressor gene mutated in multiple cancers [PDF]
, 2001 The present invention provides the isolation and cloning of WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3–24.1, a region frequently affected in several cancers.
Aldaz, C. Marcelo, Bednarek, Andrzej
core +1 more source
CellsThe human WWOX gene resides on a common fragile site and is frequently deleted or altered during DNA replication. WWOX mutations are associated with various human diseases, including cancer, neurodegeneration, and developmental deficits.
Yu-Han Su +8 more
doaj +1 more source
Introduction to a Thematic Issue for WWOX [PDF]
Experimental Biology and Medicine, 2015 Since its discovery in 2000, WW domain-containing oxidoreductase (WWOX, FOR or WOX1) has been considered as a tumor suppressor protein. Global research focus has been aimed mainly toward this direction. In this thematic issue, updated information has been collected regarding the structure, function and signaling of WWOX, along with its critical role as
openaire +1 more source