Results 41 to 50 of about 5,637 (202)
LncRNA WWOX-AS1 sponges miR-20b-5p in hepatocellular carcinoma and represses its progression by upregulating WWOX [PDF]
Cancer Biology & Therapy, 2020 Increasing evidence has revealed that long noncoding RNAs (lncRNAs) emerge as pivotal regulators in diverse cancers, including hepatocellular carcinoma (HCC). This study was conducted to investigate the role of lncRNA WWOX antisense RNA 1 (WWOX-AS1) in HCC progression.
Dafeng Xu +8 more
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VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
BMC Biology, 2018 Background The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α ...
Florian Bonin +18 more
doaj +1 more source
WWOX, A NEW POTENTIAL TUMOR SUPPRESSOR GENE [PDF]
Biomedical Papers, 2007 WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic.
Renata, Hezova +2 more
openaire +2 more sources
PLoS ONE, 2009 WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor growth.
John H Ludes-Meyers +5 more
doaj +1 more source
Mouse Models of Osteosarcoma: Unraveling Disease Mechanisms and Accelerating Drug Discovery and Development. [PDF]
Cancer Rep (Hoboken)ABSTRACT Background Osteosarcoma is the most frequent primary bone malignancy, affecting mainly children, adolescents, and young adults. For the past 40 years, improvements in the survival of patients with osteosarcoma have been minimal, primarily as a consequence of the lack of systemic therapy options beyond traditional cytotoxic agents.
Haney SL, Holstein SA.
europepmc +2 more sources
A nuclear role for the respiratory enzyme CLK-1 in regulating mitochondrial stress responses and longevity [PDF]
, 2015 The coordinated regulation of mitochondrial and nuclear activities is essential for cellular respiration and its disruption leads to mitochondrial dysfunction, a hallmark of ageing.
A Dillin +58 more
core +2 more sources
WWOX (WW domain containing oxidoreductase) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2008 Review on WWOX (WW domain containing oxidoreductase), with data on DNA, on the protein encoded, and where the gene is implicated.
Druck, Teresa +2 more
openaire +1 more source
Frontiers in Oncology, 2021 IntroductionThe presence of common fragile sites is associated with no-accidental chromosomal instability which occurs prior to carcinogenesis. The WWOX gene spans the second most active fragile site: FRA16D.
Damian Kołat +3 more
doaj +1 more source
WWOX: A fragile tumor suppressor
Experimental Biology and Medicine, 2014 WWOX, the WW domain-containing oxidoreductase gene at chromosome region 16q23.3–q24.1, spanning chromosomal fragile site FRA16D, encodes the 46 kDa Wwox protein, a tumor suppressor that is lost or reduced in expression in a wide variety of cancers, including breast, prostate, ovarian, and lung.
Morgan S, Schrock, Kay, Huebner
openaire +3 more sources
Cell Death and Disease, 2022 Pancreatic cancer is one of the most lethal cancers, owing to its late diagnosis and resistance to chemotherapy. The tumor suppressor WW domain-containing oxidoreductase (WWOX), one of the most active fragile sites in the human genome (FRA16D), is ...
Hussam Husanie +7 more
doaj +1 more source