Results 31 to 40 of about 1,108 (158)
WWOX Tumor Suppressor Gene in Breast Cancer, a Historical Perspective and Future Directions
Frontiers in Oncology, 2018 The WWOX tumor suppressor gene is located at 16q23. 1–23.2, which covers the region of FRA16D—a common fragile sites. Deletions within the WWOX coding sequence are observed in up to 80% of breast cancer cases, which makes it one of the most common ...
Karolina Pospiech +2 more
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Epigenetic and genetic alterations affect the WWOX gene in head and neck squamous cell carcinoma. [PDF]
PLoS ONE, 2015 Different types of genetic and epigenetic changes are associated with HNSCC. The molecular mechanisms of HNSCC carcinogenesis are still undergoing intensive investigation.
Seda Ekizoglu +4 more
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VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX
BMC Biology, 2018 Background The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α ...
Florian Bonin +18 more
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WWOX Oxidoreductase - Substrate and Enzymatic Characterization
Zeitschrift für Naturforschung C, 2011 WWOX is a tumour suppressor gene that spans the common fragile site FRA16D. Analysis of the WWOX expression pattern in normal human tissues showed the highest expression in testis, prostate, and ovary. Its altered expression has been demonstrated in different tissues and tumour types.
Anna, Sałuda-Gorgul +3 more
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Alteration of WWOX in human cancer, a clinical view [PDF]
Experimental Biology and Medicine, 2015 WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3–24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors.
Izabela, Baryła +2 more
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WWOX, A NEW POTENTIAL TUMOR SUPPRESSOR GENE [PDF]
Biomedical Papers, 2007 WWOX (WW domain-containing oxidoreductase) gene, located on chromosome 16q 23.3-24.1 in the region recognized as the common fragile site FRA16D is considered to be a tumor suppressor gene involved in various cancers: breast, ovarian, prostate, esophageal, lung, pancreatic, gastric and hepatic.
Renata, Hezova +2 more
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Frontiers in Genetics, 2023 Introduction: The discovery of non-coding RNA (ncRNA) dates back to the pre-genomics era, but the progress in this field is still dynamic and leverages current post-genomics solutions.
Damian Kołat +5 more
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WWOX expression in giant cell lesions of the jaws [PDF]
Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 2013 To investigate WWOX messenger RNA (mRNA) transcriptional levels in giant cell lesions (GCLs) of the jaws and associate its expression with clinical parameters.In this pilot study, quantitative reverse-transcription polymerase chain reaction was performed to analyze WWOX expression in 6 central giant cell lesions (CGCLs) (including 2 aggressive), 5 ...
Amaral, Fabrício Rezende +5 more
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WWOX : A fragile tumor suppressor
Experimental Biology and Medicine, 2014 WWOX, the WW domain-containing oxidoreductase gene at chromosome region 16q23.3–q24.1, spanning chromosomal fragile site FRA16D, encodes the 46 kDa Wwox protein, a tumor suppressor that is lost or reduced in expression in a wide variety of cancers, including breast, prostate, ovarian, and lung.
Morgan S, Schrock, Kay, Huebner
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Frontiers in Oncology, 2021 IntroductionThe presence of common fragile sites is associated with no-accidental chromosomal instability which occurs prior to carcinogenesis. The WWOX gene spans the second most active fragile site: FRA16D.
Damian Kołat +3 more
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