Results 11 to 20 of about 1,108 (158)

WWOX and Its Binding Proteins in Neurodegeneration [PDF]

Cells, 2021
WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β ...
Che-Yu Hsu, Kuan-Ting Lee, Tzu-Yu Sun, Chun-I. Sze, Shenq-Shyang Huang, Li-Jin Hsu, Nan-Shan Chang   +6 more
doaj   +7 more sources

WWOX Modulates ROS-Dependent Senescence in Bladder Cancer

Molecules, 2022
The tumor-suppressor gene, WW domain-containing oxidoreductase (WWOX), has been found to be lost in various types of cancers. ROS result as a tightly regulated signaling process for the induction of cell senescence.
Ching-Wen Liu, Po-Hen Chen, Tsan-Jung Yu, Kai-Jen Lin, Li-Ching Chang   +4 more
doaj   +2 more sources

Loss of tumor suppressor WWOX accelerates pancreatic cancer development through promotion of TGFβ/BMP2 signaling

Cell Death and Disease, 2022
Pancreatic cancer is one of the most lethal cancers, owing to its late diagnosis and resistance to chemotherapy. The tumor suppressor WW domain-containing oxidoreductase (WWOX), one of the most active fragile sites in the human genome (FRA16D), is ...
Hussam Husanie, Muhannad Abu-Remaileh, Kian Maroun, Lina Abu-Tair, Hazem Safadi, Karine Atlan, Talia Golan, Rami I. Aqeilan   +7 more
doaj   +2 more sources

WWOX tumor suppressor gene. [PDF]

Histology and histopathology, 2008
Loss of heterozygosity and chromosomal rearrangement of the WWOX gene, which is located at 16q23.3-24.1, have been detected in ovarian, breast, hepatocellular, and prostate carcinomas and in other neoplasias. This gene, which spans the common chromosomal fragile site 16D, contains 9 exons and encodes a 46 kDa WWOX protein that contains 414 amino acids.
Yang, Jilong, Zhang, Wei
openaire   +4 more sources

Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Frontiers in Oncology, 2013
Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs.
Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang   +7 more
doaj   +2 more sources

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene.

PLoS ONE, 2009
WWOX, the gene that spans the second most common human chromosomal fragile site, FRA16D, is inactivated in multiple human cancers and behaves as a suppressor of tumor growth.
John H Ludes-Meyers, Hyunsuk Kil, Jan Parker-Thornburg, Donna F Kusewitt, Mark T Bedford, C Marcelo Aldaz   +5 more
doaj   +2 more sources

Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development [PDF]

Frontiers in Neuroscience, 2020
Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with a high likelihood of premature death in animal models as well as in humans.
Michele Iacomino, Simona Baldassari, Yuki Tochigi, Katarzyna Kośla, Francesca Buffelli, Annalaura Torella, Annalaura Torella, Mariasavina Severino, Dario Paladini, Luana Mandarà, Antonella Riva, Marcello Scala, Marcello Scala, Ganna Balagura, Ganna Balagura, Andrea Accogli, Andrea Accogli, Vincenzo Nigro, Vincenzo Nigro, Carlo Minetti, Carlo Minetti, Ezio Fulcheri, Ezio Fulcheri, Federico Zara, Federico Zara, Andrzej K. Bednarek, Pasquale Striano, Pasquale Striano, Hiroetsu Suzuki, Vincenzo Salpietro, Vincenzo Salpietro, Vincenzo Salpietro   +31 more
doaj   +3 more sources

WWOX Phosphorylation, Signaling, and Role in Neurodegeneration [PDF]

Frontiers in Neuroscience, 2018
Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural diseases, metabolic disorders and early death in the newborns of humans, mice and rats.
Chan-Chuan Liu, Chan-Chuan Liu, Pei-Chuan Ho, I.-Ting Lee, Yu-An Chen, Chun-Hsien Chu, Chih-Chuan Teng, Sheng-Nan Wu, Chun-I. Sze, Chun-I. Sze, Ming-Fu Chiang, Nan-Shan Chang, Nan-Shan Chang, Nan-Shan Chang, Nan-Shan Chang   +14 more
doaj   +3 more sources

WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma [PDF]

Cancer Research, 2016
Abstract Osteosarcoma is a highly metastatic form of bone cancer in adolescents and young adults that is resistant to existing treatments. Development of an effective therapy has been hindered by very limited understanding of the mechanisms of osteosarcomagenesis. Here, we used genetically engineered mice to investigate the effects of
Del Mare, Sara, Husanie, Hussam, Iancu, Ortal, Abu Odeh, Mohammad, Evangelou, Konstantinos, Lovat, Francesca, VOLINIA, Stefano, Gordon, Jonathan, Amir, Gail, Stein, Janet, Stein, Gary S., CROCE, Carlo Maria, Gorgoulis, Vassilis, Lian, Jane B., Aqeilan, Rami I.   +14 more
openaire   +5 more sources

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science
Despite WWOX's established role as a tumor suppressor, conclusive evidence linking germline WWOX loss‐of‐function variants to oncogenesis remains scarce.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
doaj   +2 more sources