Results 11 to 20 of about 5,637 (202)

WWOX and Its Binding Proteins in Neurodegeneration [PDF]

Cells, 2021
WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β ...
Che-Yu Hsu, Kuan-Ting Lee, Tzu-Yu Sun, Chun-I. Sze, Shenq-Shyang Huang, Li-Jin Hsu, Nan-Shan Chang   +6 more
doaj   +5 more sources

Association of WWOX Gene Expression with Chronic Lymphocytic Leukemia

Namık Kemal Tıp Dergisi, 2020
Aim:The WW domain-containing oxidoreductase (WWOX) gene is located on chromosome 16q23.3-q24.1 and contains the common chromosomal fragile site, FRA16D. The WWOX gene encodes a Wwox tumor suppressor protein with a molecular weight of 46 kDa.
Halil HANCI, Birol TOPÇU, Seval AKPINAR, Burhan TURGUT, Bahadır BATAR   +4 more
doaj   +4 more sources

Normal cells repel WWOX-negative or -dysfunctional cancer cells via WWOX cell surface epitope 286-299 [PDF]

Communications Biology, 2021
Yu-An Chen et al characterize the role of cell surface epitopes of the tumor suppressor protein WWOX in cell–cell recognition. The find that cells expressing functional WWOX, repel cancer cells which express dysfunctional WWOX or lack this protein, in a ...
Yu-An Chen, Yong-Da Sie, Tsung-Yun Liu, Hsiang-Ling Kuo, Pei-Yi Chou, Yu-Jie Chen, Kuan-Ting Lee, Pin-Jun Chen, Shur-Tzu Chen, Nan-Shan Chang   +9 more
doaj   +3 more sources

LINC01137/miR-186-5p/WWOX: a novel axis identified from WWOX-related RNA interactome in bladder cancer

Frontiers in Genetics, 2023
Introduction: The discovery of non-coding RNA (ncRNA) dates back to the pre-genomics era, but the progress in this field is still dynamic and leverages current post-genomics solutions.
Damian Kołat, Żaneta Kałuzińska-Kołat, Katarzyna Kośla, Magdalena Orzechowska, Elżbieta Płuciennik, Andrzej K. Bednarek   +5 more
doaj   +3 more sources

WWOX Modulates ROS-Dependent Senescence in Bladder Cancer

Molecules, 2022
The tumor-suppressor gene, WW domain-containing oxidoreductase (WWOX), has been found to be lost in various types of cancers. ROS result as a tightly regulated signaling process for the induction of cell senescence.
Ching-Wen Liu, Po-Hen Chen, Tsan-Jung Yu, Kai-Jen Lin, Li-Ching Chang   +4 more
doaj   +3 more sources

WWOX Phosphorylation, Signaling, and Role in Neurodegeneration [PDF]

Frontiers in Neuroscience, 2018
Homozygous null mutation of tumor suppressor WWOX/Wwox gene leads to severe neural diseases, metabolic disorders and early death in the newborns of humans, mice and rats.
Chan-Chuan Liu, Chan-Chuan Liu, Pei-Chuan Ho, I.-Ting Lee, Yu-An Chen, Chun-Hsien Chu, Chih-Chuan Teng, Sheng-Nan Wu, Chun-I. Sze, Chun-I. Sze, Ming-Fu Chiang, Nan-Shan Chang, Nan-Shan Chang, Nan-Shan Chang, Nan-Shan Chang   +14 more
doaj   +3 more sources

Endogenous Processes Underlying Clock-Like Mutational Signatures. [PDF]

Genes Chromosomes Cancer
ABSTRACT Wellcome Trust scientists have shown that “mutational signatures” in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single‐base substitution (SBS) signatures, with SBS1, SBS5, and SBS40 linked to aging ...
Druck T, Aqeilan RI, Aldaz CM, Zanesi N, Huebner K.   +4 more
europepmc   +2 more sources

Folate Interaction With Genetic Risk for Neural Tube Defects Among Infants in Bangladesh. [PDF]

Birth Defects Res
ABSTRACT Background Neural tube defects such as spina bifida (SB) are congenital anomalies associated with significant morbidity and mortality worldwide. Environmental factors, particularly folate, modify SB risk. Based on recurrence rates of SB within families, genetic risk also contributes to SB development.
Mondragon-Estrada E, Wang X, Uhler MD, Farooque A, Liu K, Mukherjee SK, Ekramullah SM, Arman DM, Islam J, Suchanda HS, Christiani DC, Warf BC, Mazumdar M, Morton SU.   +13 more
europepmc   +2 more sources

Loss of wwox expression in zebrafish embryos causes edema and alters Ca2+ dynamics [PDF]

PeerJ, 2015
We investigated the role of the WW domain-containing oxidoreductase (wwox) gene in the embryonic development of zebrafish, with particular emphasis on intracellular Ca2+ dynamics because Ca2+ is an important intracellular messenger.
Yusuke Tsuruwaka, Masataka Konishi, Eriko Shimada   +2 more
doaj   +2 more sources

WWOX Controls Cell Survival, Immune Response and Disease Progression by pY33 to pS14 Transition to Alternate Signaling Partners

Cells, 2022
Tumor suppressor WWOX inhibits cancer growth and retards Alzheimer’s disease (AD) progression. Supporting evidence shows that the more strongly WWOX binds intracellular protein partners, the weaker is cancer cell growth in vivo.
Tsung-Yun Liu, Ganesan Nagarajan, Ming-Fu Chiang, Shenq-Shyang Huang, Tzu-Chia Lin, Yu-An Chen, Chun-I Sze, Nan-Shan Chang   +7 more
doaj   +1 more source