Results 21 to 30 of about 1,108 (158)
HYAL-2–WWOX–SMAD4 signaling in cell death and anticancer response
Frontiers in Cell and Developmental Biology, 2016 Hyaluronidase HYAL-2 is a membrane-anchored protein and also localizes, in part, in the lysosome. Recent study from animal models revealed that both HYAL-1 and HYAL-2 are essential for the metabolism of hyaluronan (HA).
Li-Jin Hsu +7 more
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WWOX somatic ablation in skeletal muscles alters glucose metabolism
Molecular Metabolism, 2019 Objective: WWOX, a well-established tumor suppressor, is frequently lost in cancer and plays important roles in DNA damage response and cellular metabolism.
Muhannad Abu-Remaileh +7 more
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WWOX in biological control and tumorigenesis [PDF]
Journal of Cellular Physiology, 2007 AbstractThe WW domain‐containing oxidoreductase (WWOX) gene is located at 16q23.1–16q23.2, a region that spans the second most common human fragile site, FRA16D. The WWOX protein contains two N‐terminal WW domains and a central short chain oxidoreductase‐like domain.
Rami I, Aqeilan, Carlo M, Croce
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The WWOX gene in brain development and pathology [PDF]
Experimental Biology and Medicine, 2020 Shortly after its discovery in 2000, WWOX was hailed as a tumor suppressor gene. In subsequent years of research, this function was confirmed indisputably. Majority of tumors show high rate of loss of heterozygosity and decreased expression of WWOX. Nevertheless, over the years, the range of its known functions, at the cellular, organ and system levels,
K Kośla, Ż Kałuzińska, AK Bednarek
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Association of Wwox with ErbB4 in Breast Cancer [PDF]
Cancer Research, 2007 Abstract WWOX, WW domain-containing oxidoreductase, is a tumor suppressor that is altered in many human cancers, including breast cancer. Wwox interacts with the ErbB4 receptor, reduces nuclear translocation of the cleaved intracellular domain of ErbB4, and inhibits its transactivation function mediated through Yes-associated protein.
Rami I, Aqeilan +11 more
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, 2023 Introduction: The discovery of non-coding RNA (ncRNA) dates back to the pre-genomics era, but the progress in this field is still dynamic and leverages current post-genomics solutions.
Żaneta Kałuzińska-Kołat (16538187) +11 more
core +1 more source
WWOX loss activates aerobic glycolysis [PDF]
Molecular & Cellular Oncology, 2014 Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch.
Abu-Remaileh, Muhannad +2 more
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Frontiers in Cell and Developmental Biology, 2020 Deficiency of tumor suppressor WW domain-containing oxidoreductase (WWOX) in humans and animals leads to growth retardation and premature death during postnatal developmental stages. Skin integrity is essential for organism survival due to its protection
Ying-Tsen Chou +6 more
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Communications Biology, 2021 Yu-An Chen et al characterize the role of cell surface epitopes of the tumor suppressor protein WWOX in cell–cell recognition. The find that cells expressing functional WWOX, repel cancer cells which express dysfunctional WWOX or lack this protein, in a ...
Yu-An Chen +9 more
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A Role for the WWOX Gene in Prostate Cancer [PDF]
Cancer Research, 2006 Abstract Expression of the WWOX gene, encompassing the common chromosome fragile site FRA16D, is altered in a large fraction of cancers of various types, including prostate cancer. We have examined expression and biological functions of WWOX in prostate cancer.
QIN HR +9 more
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