Results 21 to 30 of about 5,637 (202)

The degree of segmental aneuploidy measured by total copy number abnormalities predicts survival and recurrence in superficial gastroesophageal adenocarcinoma [PDF]

, 2014
Background: Prognostic biomarkers are needed for superficial gastroesophageal adenocarcinoma (EAC) to predict clinical outcomes and select therapy. Although recurrent mutations have been characterized in EAC, little is known about their clinical and ...
A Janssen, AH Marx, AJ Lee, AM Dulak, AM Dulak, B Fu, BJ Reid, CA Ong, CD Schweighofer, Christin M. Sciulli, CM Jacobsen, D Choma, D Hanahan, D Hirsch, DJ Nancarrow, DP Cahill, ER Thompson, F Boudreau, G Ng, GA Prasad, George K. Michalopoulos, GJ Kops, H Lango Allen, H Pohl, HJ Stein, J Gu, J Theisen, J. Michael Krill-Burger, James D. Luketich, JC Saldivar, JO Korbel, Jon M. Davison, Katie S. Nason, L Lin, LA Lai, LO Baumbusch, Lori A. Kelly, M Greaves, M Sarbia, M Schweigert, M Tuefferd, Maureen A. Lyons-Weiler, MB Menke-Pluymers, Melissa Yee, N Deng, N McGranahan, NJ Birkbak, NS Chang, O Pech, OM Radu, PJ Stephens, R Beroukhim, R Roylance, S Bayraktar, S Li, SE Araujo, SL Carter, Svetlana Pack, T Nakamura, TM Kim, TW Rice, TW Rice, VI Gaidzik, William A. LaFramboise, WJ Blot, WJ Kent, XY Goh, YJ Bang   +67 more
core   +10 more sources

Characterization of WWOX expression and function in canine mast cell tumors and malignant mast cell lines

BMC Veterinary Research, 2020
Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA
Rebecca Makii, Hanna Cook, Darian Louke, Justin Breitbach, Ryan Jennings, Christopher Premanandan, Eric M. Green, Joelle M. Fenger   +7 more
doaj   +1 more source

WWOX loss activates aerobic glycolysis [PDF]

Molecular & Cellular Oncology, 2014
Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis-a state known as "aerobic glycolysis." Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch.
Abu-Remaileh, Muhannad, Seewaldt, Victoria L, Aqeilan, Rami I   +2 more
openaire   +2 more sources

Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. [PDF]

PLoS ONE, 2012
Loss of WWOX expression has been reported in many different cancers including breast cancer. Elucidating the function of this gene in adult tissues has not been possible with full Wwox knockout models. Here we characterize the first conditional models of
Brent W Ferguson, Xinsheng Gao, Hyunsuk Kil, Jaeho Lee, Fernando Benavides, Martin C Abba, C Marcelo Aldaz   +6 more
doaj   +1 more source

Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk. [PDF]

PLoS ONE, 2017
BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Human WW domain-containing oxidoreductase (WWOX) gene has been identified as a tumor suppressor gene in multiple cancers.
Hsiang-Lin Lee, Hsin-Lin Cheng, Yu-Fan Liu, Ming-Chih Chou, Shun-Fa Yang, Ying-Erh Chou   +5 more
doaj   +1 more source

WWOX in biological control and tumorigenesis [PDF]

Journal of Cellular Physiology, 2007
AbstractThe WW domain‐containing oxidoreductase (WWOX) gene is located at 16q23.1–16q23.2, a region that spans the second most common human fragile site, FRA16D. The WWOX protein contains two N‐terminal WW domains and a central short chain oxidoreductase‐like domain.
Rami I, Aqeilan, Carlo M, Croce
openaire   +2 more sources

Tumor Suppressor WWOX Contributes to the Elimination of Tumorigenic Cells in Drosophila melanogaster. [PDF]

PLoS ONE, 2015
WWOX is a >1 Mb gene spanning FRA16D Common Chromosomal Fragile Site, a region of DNA instability in cancer. Consequently, altered WWOX levels have been observed in a wide variety of cancers. In vitro studies have identified a large number and variety of
Louise V O'Keefe, Cheng Shoou Lee, Amanda Choo, Robert I Richards   +3 more
doaj   +1 more source

Single Nucleotide Polymorphism Microarray Analysis Unveils Copy-Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B-Cell Precursor Acute Lymphoblastic Leukemia. [PDF]

Mol Genet Genomic Med
B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) is a prevalent pediatric hematologic malignancy characterized by diverse chromosomal aberrations that significantly influence its prognosis. This study aimed to comprehensively characterize the genomic landscape of childhood BCP‐ALL in a cohort of 55 Malaysian patients.
Mohd Dali NS, Aziz NA, Zulkifle MF, Zamri DA, Kamaluddin NR, Yeoh SL, Ho BL, Din ND, Ab Ghani AS, Wan Hassan WAH, Zakaria Z, Esa E, Mat Yusoff Y.   +12 more
europepmc   +2 more sources

Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. [PDF]

, 2014
BackgroundSince tumor suppressor gene function may be lost through hypermethylation, we assessed whether the demethylating agent decitabine could increase tumor suppressor gene expression clinically.
Aldaz, Marcelo, Gupta, Sanjay, Hong, David, Issa, Jean-Pierre, Jelinek, Jaroslav, Kurzrock, Razelle, Nunez, Maria I, Stewart, David J, Wistuba, Ignacio I   +8 more
core   +3 more sources

Wwox Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin

Frontiers in Cell and Developmental Biology, 2020
Deficiency of tumor suppressor WW domain-containing oxidoreductase (WWOX) in humans and animals leads to growth retardation and premature death during postnatal developmental stages. Skin integrity is essential for organism survival due to its protection
Ying-Tsen Chou, Feng-Jie Lai, Feng-Jie Lai, Nan-Shan Chang, Nan-Shan Chang, Li-Jin Hsu, Li-Jin Hsu   +6 more
doaj   +1 more source