Results 51 to 60 of about 1,108 (158)
Movement Disorders Clinical Practice, EarlyView.Abstract Background Childhood‐onset hyperkinetic movement disorders occur in a range of genetic conditions. Recently, there has been an increase in recognition of hyperkinetic movement disorders, mainly dystonia, chorea and dyskinesia, with monogenic conditions associated with neurodevelopmental delay (NDD) and also with developmental and epileptic ...
Hugo Morales‐Briceño +6 more
wiley +1 more source
The fragile site WWOX gene and the developing brain [PDF]
Experimental Biology and Medicine, 2014 WWOX was cloned as a tumor suppressor gene mapping to chromosomal fragile site FRA16D. Loss of WWOX is closely related to tumorigenesis, cancer progression, and therapy resistance. Recent studies demonstrate the growing role of WWOX gene in other human pathologies such as metabolic and nervous system-related conditions. The neurologic phenotype of WWOX
Brahim, Tabarki +2 more
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Characterization of WWOX Inactivation in Murine Mammary Gland Development [PDF]
, 2012 The WW domain-containing oxidoreductase (WWOX) is commonly inactivated in multiple human cancers, including breast cancer. Wwox null mice die prematurely precluding adult tumor analysis.
Khawaled, Saleh +3 more
core +1 more source
Natural Product‐Induced Ferroptosis to Overcome Therapy Resistance in Aggressive Cancers
ChemMedChem, Volume 21, Issue 20, 28 October 2026.Natural products trigger ferroptosis through iron overload, glutathione depletion, glutathione peroxidase 4 inhibition, and reactive oxygen species accumulation, selectively targeting aggressive, and drug‐resistant cancers. Polyphenols, alkaloids and terpenoids emerge as promising multi‐target agents to overcome therapy resistance and improve future ...
Giorgio Antoniolli
wiley +1 more source
Neurobiology of Disease, 2019 The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented.
Tabish Hussain +11 more
doaj +1 more source
Molecular Biology of the WWOX Gene That Spans Chromosomal Fragile Site FRA16D
Cells, 2021 It is now more than 20 years since the FRA16D common chromosomal fragile site was characterised and the WWOX gene spanning this site was identified. In this time, much information has been discovered about its contribution to disease; however, the normal
Cheng Shoou Lee +4 more
doaj +1 more source
AGING MEDICINE, Volume 9, Issue 5, Page 495-509, October 2026.Blood‐based biomarkers are emerging as accessible tools for Alzheimer's disease screening, diagnosis, risk stratification, and longitudinal monitoring. This review summarizes major biomarkers, including Aβ42/Aβ40, phosphorylated tau species, NfL, GFAP, genetic risk markers, and exploratory inflammatory, synaptic, and proteomic candidates.
Shuangshuang Li, Lin Huang, Qihao Guo
wiley +1 more source
WWOX-related epileptic encephalopathy caused by a novel mutation in the WWOX gene: a case report
Frontiers in PediatricsBackground WWOX -related epileptic encephalopathy is an autosomal recessive disorder caused by mutations in the WW-containing oxidoreductase gene, characterized by the onset of refractory seizures in infants. Early-onset epilepsy, electroencephalography abnormalities,
Dan Feng +5 more
openaire +3 more sources
Targeted deletion of Wwox reveals a tumor suppressor function
, 2011 The WW domain-containing oxidoreductase (WWOX) spans the second most common fragile site of the human genome, FRA16D, located at 16q23, and its expression is altered in several types of human cancer.
Lian, Jane B. +11 more
core +1 more source
Role of Tumor Suppressor WWOX in Modulating PD-L1 Expression in Breast Cancers
ExperimedObjective: This study aimed to determine the potential contribution of WWOX to the regulation of PD-L1 expression in breast cancer.Materials and Methods: MDA-MB-231, MCF-7, and MCF10A cell lines were used in this study. The WWOX gene was overexpressed in
Sümbül Gezer, Bahadır Batar
doaj +1 more source