Results 51 to 60 of about 5,637 (202)

Expression of the IL-11 Gene in Metastatic Cells Is Supported by Runx2-Smad and Runx2-cJun Complexes Induced by TGFβ1. [PDF]

, 2015
In tumor cells, two factors are abnormally increased that contribute to metastatic bone disease: Runx2, a transcription factor that promotes expression of metastasis related and osteolytic genes; and IL-11, a secreted osteolytic cytokine.
Afzal, Akech, Ali, Aqeilan, Bamba, Begley, Buijs, Calon, Campbell, Casimiro, D'Alonzo, Deng, Dutta, Eswaraka, Fradet, Furuya, Gordon, Hess, Huang, Ikushima, Iranikhah, Javed, Kamradt, Kang, Koeneman, Lay, Leong, Massague, Mathew, Matsumoto, Matsumura, McCoy, Mendoza-Villanueva, Morrissey, Necula, Ortiz, Padua, Pratap, Pratap, Pratap, Schroeder, Selvamurugan, Shen, Sottnik, Stein, Tang, Tang, Tohjima, van der Deen, Wan, Weilbaecher, Xiang, Yang, Yang, Yang, Young, Zaidi, Zhang, Zhang, Zurita   +59 more
core   +2 more sources

WWOX Oxidoreductase - Substrate and Enzymatic Characterization

Zeitschrift für Naturforschung C, 2011
WWOX is a tumour suppressor gene that spans the common fragile site FRA16D. Analysis of the WWOX expression pattern in normal human tissues showed the highest expression in testis, prostate, and ovary. Its altered expression has been demonstrated in different tissues and tumour types.
Anna, Sałuda-Gorgul, Karolina, Seta, Magdalena, Nowakowska, Andrzej K, Bednarek   +3 more
openaire   +2 more sources

Genome-wide association analysis identifies six new loci associated with forced vital capacity [PDF]

, 2014
Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and ...
A Bill Musk, A Hofman, A Rosendahl, A Sountoulidis, Adaikalavan Ramasamy, Akshay Sood, AL Dixon, Alan F Wright, Alan L James, Alanna C Morrison, Albert Hofman, Albert Vernon Smith, Alexander Teumer, Alexessander Couto Alves, Alicja R Rudnicka, Ana Viñuela, Andrew P Morris, André G Uitterlinden, Ani Manichaikul, Anne Newman, Anne Viljanen, Anneli Pouta, AP Boyle, AS Dimas, AT Kho, B Devlin, B Gombojav, B Servin, Beate Koch, Bharat Thyagarajan, BL Browning, Blair H Smith, Bonnie R Joubert, Bruce M Psaty, Bruno H Stricker, Caroline Hayward, CE Elks, Chris Oldmeadow, Christian Gieger, Christopher J Hammond, Cisca Wijmenga, CJ Willer, CJ Zappala, Claudia Flexeder, CM Lindgren, CS Carlson, Daan W Loth, Dana B Hancock, David Couper, David J Lederer, David J Porteous, David P Strachan, DB Hancock, DB Hancock, Deborah L Jarvis, Dirkje S Postma, DJ Gottlieb, DR Nyholt, E Hodge, E Melén, E Repapi, EE Eichler, Elizabeth G Holliday, Erik Ingelsson, Erik Melén, Ernst Omenaas, Esteban G Burchard, Eva Albrecht, F Ashley, Fernando Rivadeneira, Fien M Verhamme, G Lettre, G Raghu, Gail Davies, Generation Scotland, George T O'Connor, Gudny Eiriksdottir, Guo Li, Guy G Brusselle, H Lango Allen, H Marike Boezen, H Takizawa, Harald Grallert, Harry Campbell, Henry Völzke, HJ Westra, HM Lee, Holger Schulz, Holly Trochet, Ian J Deary, Ian P Hall, Ian Sayers, Ida Surakka, Igor Rudan, Isabelle Pin, Ivana Kolcic, J Li, J Marchini, J Sung, J Sung, J Yang, Jaakko Kaprio, James F Wilson, JB Wilk, JB Wilk, Jemma B Wilk, Jennie Hui, Jennifer E Huffman, Jerome I Rotter, JH Park, Jing Hua Zhao, JM Cheverud, Joachim Heinrich, John Beilby, John M Starr, John R Attia, Joohon Sung, Josée Dupuis, Joyce B J van Meurs, JR Gibbs, Judith M Vonk, Juha Pekkanen, K Musunuru, K Zhang, Kari E North, Ken R Bracke, Kim de Jong, Kirsi H Pietiläinen, Kristin M Burkart, Kurt Lohman, Lars Lind, Laura R Loehr, Lenore J Launer, Leslie A Lange, Lewis J Smith, Lies Lahousse, Lina Zgaga, LJ Palmer, Lorna M Lopez, Louise V Wain, M Kimura, M Soler Artigas, M Uhlen, Marcy F Petrini, Marjo-Riitta Jarvelin, Marjolein J Peters, Markku Heliövaara, Martin D Tobin, Mary Wojczynski, María Soler Artigas, Matthias Wjst, Melissa Garcia, Mi Kyeong Lee, Mika Kähönen, Myriam Fornage, N van Putte-Katier, Nadia Hansel, Nathan C Gaddis, Nicholas D Hastie, Nicholas J Wareham, Nora Franceschini, O Dale Williams, Ozren Polasek, P Lange, Patricia A Cassano, Pau Navarro, Peter K Joshi, PG Burney, Pieter S Hiemstra, Pirro G Hysi, PJ McLaughlin, Qing Duan, R Graham Barr, Rajesh Kumar, Regina Hampel, Robert A Scott, Rodney J Scott, Ryan L Minster, Samuli Ripatti, Sarah H Wild, Sina A Gharib, SR Browning, ST Weiss, Stefan Enroth, Stefan Karrasch, Stephanie J London, Stephen B Kritchevsky, Stephen S Rich, Susan Campbell, Susan R Heckbert, Susan Redline, Sven Gläser, Taina Rantanen, Tamara B Harris, Tatijana Zemunik, Tess D Pottinger, Thomas Lumley, Thor Aspelund, Timothy D Spector, Tove Fall, Ulf Gyllensten, Veronique Vitart, Vilmundur Gudnason, WB Kannel, Wei Gao, Wenbo Tang, Wendy B White, Wendy L McArdle, WI de Boer, Woo Jin Kim, Xiangjun Gu, Xin-Qun Wang, Y Li, Yeon-Mok Oh, Yongmei Liu, YS Cho, Åsa Johansson   +216 more
core   +4 more sources

Dynamic expression of genes associated with schizophrenia and bipolar disorder across development [PDF]

, 2019
Common genetic variation contributes a substantial proportion of risk for both schizophrenia and bipolar disorder. Furthermore, there is evidence of significant, but not complete, overlap in genetic risk between the two disorders.
Clifton, Nicholas E., Di Florio, Arianna, Hall, Jeremy, Hannon, Eilis, Harwood, Janet C., Holmans, Peter A., O'Donovan, Michael, Owen, Michael J., Pocklington, Andrew J., Thomas, Kerrie L., Walters, James T. R.   +10 more
core   +3 more sources

WWOX guards genome stability by activating ATM [PDF]

Molecular & Cellular Oncology, 2015
Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be "hot spots" for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates ...
Hazan, Idit, Abu-Odeh, Mohammad, Hofmann, Thomas G, Aqeilan, Rami I   +3 more
openaire   +2 more sources

A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

Cell Communication and Signaling, 2019
Background Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we investigated the formation of WWOX/TIAF1/p53 triad and its regulation of cancer cell ...
Pei-Yi Chou, Sing-Ru Lin, Ming-Hui Lee, Lori Schultz, Chun-I Sze, Nan-Shan Chang   +5 more
doaj   +1 more source

The effects of protocadherin 8 and WWOX in prostate adenocarcinoma

Journal of Men's Health, 2022
Objective: The protocadherin 8 (PCDH8) gene, located on chromosome 13q14.3 encodes an integral membrane protein. WWOX (fragile site FRA16D oxido-reductase) is a tumor suppressor gene located in region 16q23.324.1. The aim of this study was to investigate
Mürüvvet Akçay Çelik, Havva Erdem, Soner Çankaya, Yeliz Kaşko Arıcı   +3 more
doaj   +1 more source

Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved

Frontiers in Oncology, 2018
It has become clear from multiple studies that WWOX (WW domain-containing oxidoreductase) operates as a “non-classical” tumor suppressor of significant relevance in cancer progression.
Tabish Hussain, Jaeho Lee, Martin C. Abba, Junjie Chen, C. Marcelo Aldaz   +4 more
doaj   +1 more source

WWOX promotes osteosarcoma development via upregulation of Myc

Cell Death & Disease, 2023
Abstract Osteosarcoma is an aggressive bone tumor that primarily affects children and adolescents. This malignancy is highly aggressive, associated with poor clinical outcomes, and primarily metastasizes to the lungs.
Rania Akkawi, Osama Hidmi, Ameen Haj-Yahia, Jonathon Monin, Judith Diment, Yotam Drier, Gary S. Stein, Rami I. Aqeilan   +7 more
openaire   +3 more sources

Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Frontiers in Oncology, 2013
Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs.
Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang   +7 more
doaj   +1 more source