Results 71 to 80 of about 5,637 (202)
WWOX, large common fragile site genes, and cancer [PDF]
Experimental Biology and Medicine, 2015 WWOX is a gene that spans an extremely large chromosomal region. It is derived from within chromosomal band 16q23.2 which is a region with frequent deletions and other alterations in a variety of different cancers. This chromosomal band also contains the FRA16D common fragile site (CFS).
Ge, Gao, David I, Smith
openaire +2 more sources
Frontiers in Oncology, 2019 WWOX (WW domain containing oxidoreductase) expression loss is common in various cancers and characteristic of poor prognosis. Deletions, translocations, and loss of expression affecting the WWOX gene are a common feature of various B cell neoplasms such ...
Kevin M. McBride +8 more
doaj +1 more source
WW domain-containing oxidoreductase-related epileptic encephalopathy in Two Omani Children.
Journal of Biochemical and Clinical Genetics, 2023 Background: Autosomal recessive developmental and epileptic encephalopathy type 28 (DEE28) is a rare genetic disorder that affects children in the early months of life.
Moosa Al-Lawati +7 more
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Neurobiology of Disease, 2021 Summary: Loss of function mutations of the WW domain-containing oxidoreductase (WWOX) gene are associated with severe and fatal drug-resistant pediatric epileptic encephalopathy.
Vanessa L. Breton +8 more
doaj +1 more source
Synorth: exploring the evolution of synteny and long-range regulatory interactions in vertebrate genomes [PDF]
, 2009 Genomic regulatory blocks are chromosomal regions spanned by long clusters of highly conserved noncoding elements devoted to long-range regulation of developmental genes, often immobilizing other, unrelated genes into long-lasting syntenic arrangements ...
Dong, Xianjun +2 more
core +3 more sources
Epidemiology of progressive intellectual and neurological deterioration in UK children
Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity +3 more
wiley +1 more source
Association of Wwox with ErbB4 in Breast Cancer [PDF]
Cancer Research, 2007 Abstract WWOX, WW domain-containing oxidoreductase, is a tumor suppressor that is altered in many human cancers, including breast cancer. Wwox interacts with the ErbB4 receptor, reduces nuclear translocation of the cleaved intracellular domain of ErbB4, and inhibits its transactivation function mediated through Yes-associated protein.
Rami I, Aqeilan +11 more
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Biology, 2023 Following the discovery of WWOX, research has moved in many directions, including the role of this putative tumor suppressor in the central nervous system and related diseases.
Żaneta Kałuzińska-Kołat +4 more
doaj +1 more source
The insider's perspective: The intracellular complosome and immune cell dynamics in cancer
Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.Intracellular complement (complosome) shapes the tumour immune microenvironment. Complosome's role in cancer is underrecognised yet central to tumour immunity. C3/C5‐driven complosome signals rewire T‐cell activation, fate and metabolism. Complosome activity can promote pro‐tumour immune cell function.
Alexandra Bennion +2 more
wiley +1 more source
Decreased WWOX expression promotes angiogenesis in osteosarcoma
Oncotarget, 2017 WWOX (WW domain-containing oxidoreductase) is known to be an important tumor suppressor in cancer. In this study, we used samples from 201 osteosarcoma patients to investigate the effects of WWOX on angiogenesis and invasion. WWOX levels were negatively correlated with RUNX2 and VEGF levels, but were not correlated with OPN levels.
Wen, Jia +7 more
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