Results 71 to 80 of about 1,108 (158)
Epileptic Disorders, Volume 28, Issue 4, Page 1252-1273, August 2026.Abstract Objective To evaluate the diagnostic utility and genetic spectrum of next‐generation sequencing (NGS) in a large, well‐phenotyped cohort of Turkish pediatric patients with epilepsy of unknown etiology. Methods Between January 2021 and December 2024, 250 children (115 female, 135 male) with unexplained epilepsy underwent either whole‐exome ...
Derya Karaer +4 more
wiley +1 more source
Decreased WWOX expression promotes angiogenesis in osteosarcoma
Oncotarget, 2017 WWOX (WW domain-containing oxidoreductase) is known to be an important tumor suppressor in cancer. In this study, we used samples from 201 osteosarcoma patients to investigate the effects of WWOX on angiogenesis and invasion. WWOX levels were negatively correlated with RUNX2 and VEGF levels, but were not correlated with OPN levels.
Wen, Jia +7 more
openaire +3 more sources
Neurobiology of Disease, 2021 Summary: Loss of function mutations of the WW domain-containing oxidoreductase (WWOX) gene are associated with severe and fatal drug-resistant pediatric epileptic encephalopathy.
Vanessa L. Breton +8 more
doaj +1 more source
Astrocytes in Genetic Epilepsies: Supporting Actor or Key Player?
Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.Astrocytes contribute to the pathophysiology of acquired epilepsy. However, less is known about their contribution to genetic epilepsy syndromes which often exhibit frequent comorbidity with neurodevelopmental and psychiatric disorders. Epileptic seizures are also frequently present in neurodevelopmental disorders.
Jenny Lange +4 more
wiley +1 more source
Biology, 2023 Following the discovery of WWOX, research has moved in many directions, including the role of this putative tumor suppressor in the central nervous system and related diseases.
Żaneta Kałuzińska-Kołat +4 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, Volume 20, Issue 7, Page 1667-1693, July 2026.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Genotypes of pups from Wwox+/ΔCre × Wwox+/ΔCre crosses.
, 2013 Genotypes of pups from Wwox+/ΔCre × Wwox+/ΔCre crosses.
Mark T. Bedford (182601) +5 more
core +1 more source
Frontiers in Cellular Neuroscience, 2019 The brain is the most functionally organized structure of all organs. It manages behavior, perception and higher cognitive functions. The WWOX gene is non-classical tumor suppressor gene, which has been shown to have an impact on proliferation, apoptosis
Katarzyna Kośla +5 more
doaj +1 more source
Correlation between osteosarcoma and the expression of WWOX and p53
Oncology Letters, 2017 The objective of this study was to analyze the effect of the expression of WWOX and p53 on the growth of MG-63 osteosarcoma cells and to explore the correlation between osteosarcoma and the expression of WWOX and p53. WWOX and p53-overexpressing MG-63 osteosarcoma cell lines were established by transfection and named the MW and MP cell lines ...
Liu, Pingtao +3 more
openaire +3 more sources
Deletion of Wwox results in defective mammary branching and lobuloalveolar development.
, 2012 (A–B) Representative microphotographs obtained from whole mounts of 12 week virgin BK5 Wwox WT (A) and KO (B) mammary glands. The impaired branching phenotype was also dramatically evident in mammary gland from MMTV KO mice as illustrated in (C), extreme
Xinsheng Gao (167498) +6 more
core +1 more source