Results 91 to 100 of about 5,637 (202)

WWOX Drives T Leukemia Cell Maturation via IκBα/WWOX/ERK Signal Pathway

Journal of Tumor Research, 2017
Forced differentiation therapy has been shown to be effective in suppressing promyelocytic leukemia cell growth and other types of cancer cells in patients. A combination of calcium ionophore and phorbol ester is effective in inducing terminal maturation of T-cell acute lymphoblastic leukemia (T-ALL), in which it requires the signaling of IκBα/WWOX/ERK.
openaire   +1 more source

The RAG Model: a new paradigm for genetic risk stratification in multiple myeloma [PDF]

, 2014
Molecular studies have shown that multiple myeloma is a highly genetically heterogonous disease which may manifest itself as any number of diverse subtypes each with variable clinicopathological features and outcomes.
Chevassut, Timothy J, Conway O'Brien, Emma, Prideaux, Steven M   +2 more
core   +3 more sources

The Role of DNA Methyltransferases in Urinary System Diseases

Cancer Innovation, Volume 4, Issue 6, December 2025.
Multiple signaling pathways mediated by DNMTs in the formation of renal fibrosis: (a) DNMTs suppress the expression of transcription factor KLF4 by mediating promoter hypermethylation, thereby promoting epithelial–mesenchymal transition and contributing to the development of renal fibrosis; (b) oxidative stress can upregulate the levels of DNMTs, which
Wei Dong, Shengbin Pei, Dacheng Zhu, Cheng Zeng, Yue Qiu, Yuxin Wu, Xinlu Jia, Siqi Zhang, Chao Li, Wenjuan Zhang, Wenbing Zhang, Zhihua Chen   +11 more
wiley   +1 more source

WWOX Mutation as a Rare Cause of Neonatal‐Infantile Parkinsonism Mimicking a Neurotransmitter Disorder: A Case Report

Journal of Paediatrics and Child Health, EarlyView.
Ozge Serce Pehlevan, Gizem Gider Yaman, Anıl Gok, Leman Tekin Orgun   +3 more
wiley   +1 more source

Decoding the Cryptic Proteome Between Antigens and Novel Functional Proteins

European Journal of Immunology, Volume 55, Issue 12, December 2025.
Unannotated splicing and translation of non‐canonical open reading frames generate a diverse repertoire of cryptic proteins. Most are rapidly degraded, rendering them possible MHC‐I substrates. Yet, a subpopulation can adopt stable structures and impart advantageous functions.
Emma G. Bawden, Sebastian Amigorena, Yago A. Arribas   +2 more
wiley   +1 more source

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Acta Neuropathologica Communications, 2020
Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations in both alleles of WWOX gene lead to autosomal recessive abnormalities in pediatric ...
Ya-Yun Cheng, Ying-Tsen Chou, Feng-Jie Lai, Ming-Shiou Jan, Tsung-Hao Chang, I-Ming Jou, Pei-Shiuan Chen, Jui-Yen Lo, Shiang-Suo Huang, Nan-Shan Chang, Yung-Tsai Liou, Po-Chih Hsu, Hui-Ching Cheng, Yee-Shin Lin, Li-Jin Hsu   +14 more
doaj   +1 more source

HACE1 deficiency causes an autosomal recessive neurodevelopmental syndrome [PDF]

, 2015
Background: The genetic etiology of neurodevelopmental defects is extremely diverse, and the lack of distinctive phenotypic features means that genetic criteria are often required for accurate diagnostic classification. We aimed to identify the causative
Abdel-Salam, Ahram, Alexander F Markham, Anglesio, Au, Carr, Chang, Christopher P Bennett, Clare V Logan, Corcoran, David A Parry, David T Bonthron, Deciphering Developmental Disorders Study, Eamonn G Sheridan, Frank J Kaiser, Gabriele Gillessen-Kaesbach, Georg C Korenke, Hadchouel, Haruta, Hibi, Hu, Ian M Carr, Kaartinen, Lachance, Lewerenz, Lisa Nalbach, Luo, Mallaret, Mulherkar, Mushtaq Ahmed, Nagase, Parry, Ronja Hollstein, Sakata, Sandeep Uppal, Schwarz, Slade, Song, Tang, Thomas Wieland, Tim M Strom, Torrino, Verity L Hartill, Yu, Zhang, Zhao   +45 more
core   +3 more sources

Loss of lung WWOX expression causes neutrophilic inflammation [PDF]

American Journal of Physiology-Lung Cellular and Molecular Physiology, 2017
The tumor suppressor WW domain-containing oxidoreductase (WWOX) exhibits regulatory interactions with an array of transcription factors and signaling molecules that are positioned at the well-known crossroads between inflammation and cancer. WWOX is also subject to downregulation by genotoxic environmental exposures, making it of potential interest to ...
Sunit, Singla, Jiwang, Chen, Shruthi, Sethuraman, Justin R, Sysol, Amulya, Gampa, Shuangping, Zhao, Roberto F, Machado   +6 more
openaire   +2 more sources

WWOX Suppresses Cell Growth and Induces Cell Apoptosis via Inhibition of P38 Nuclear Translocation in Cholangiocarcinoma

Cellular Physiology and Biochemistry, 2014
Background: Extrahepatic cholangiocarcinoma (EHCC) is the second most common primary hepatic malignancy, and is associated with high morbidity and mortality.
Mei Wang, Yongmei Li, Meihong Wu, Wei Wang, Biao Gong, Yajie Wang   +5 more
doaj   +1 more source

Genome-Wide Copy Number Analysis in Esophageal Adenocarcinoma Using High-Density Single-Nucleotide Polymorphism Arrays [PDF]

, 2008
We applied whole-genome single-nucleotide polymorphism arrays to define a comprehensive genetic profile of 23 esophageal adenocarcinoma (EAC) primary tumor biopsies based on loss of heterozygosity (LOH) and DNA copy number changes.
Clouston, Andrew D, Drew, Paul Anthony, Gotley, David C, Handoko, Herlina Y, Hayward, Nicholas K, Nancarrow, Derek J, Smithers, B Mark, Watson, David Ian, Whiteman, David C   +8 more
core   +1 more source