Results 91 to 100 of about 1,108 (158)

Analysis of WWOX gene expression and protein levels in pterygium

International Ophthalmology, 2020
Pterygium, a degenerative and hyperplastic lesion, has premalignant properties as a tumor analog. WWOX is a tumor suppressor gene and involved in many signal pathways, such as cell proliferation, embryonic development, metabolism and apoptosis. In many cancers, the loss of WWOX or the presence of abnormal transcripts indicates the tumor suppressor ...
Bozkurt, Nihan, Ates, Omer
openaire   +3 more sources

Single Nucleotide Polymorphism Microarray Analysis Unveils Copy‐Number Abnormalities and Genetic Heterogeneity in Malaysian Childhood B‐Cell Precursor Acute Lymphoblastic Leukemia

Molecular Genetics &Genomic Medicine, Volume 14, Issue 3, March 2026.
B‐cell precursor acute lymphoblastic leukemia (BCP‐ALL) is a prevalent pediatric hematologic malignancy characterized by diverse chromosomal aberrations that significantly influence its prognosis. This study aimed to comprehensively characterize the genomic landscape of childhood BCP‐ALL in a cohort of 55 Malaysian patients.
Nor Soleha Mohd Dali, Nursaedah Abdullah Aziz, Muhamad Farid Zulkifle, Durar Aqilah Zamri, Nor Rizan Kamaluddin, Seoh‐Leng Yeoh, Betty Lee‐Sue Ho, Nazzlin Dizana Din, Azly Sumanty Ab Ghani, Wan Amal Hayati Wan Hassan, Zubaidah Zakaria, Ezalia Esa, Yuslina Mat Yusoff   +12 more
wiley   +1 more source

Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice

Acta Neuropathologica Communications, 2020
Human WWOX gene resides in the chromosomal common fragile site FRA16D and encodes a tumor suppressor WW domain-containing oxidoreductase. Loss-of-function mutations in both alleles of WWOX gene lead to autosomal recessive abnormalities in pediatric ...
Ya-Yun Cheng, Ying-Tsen Chou, Feng-Jie Lai, Ming-Shiou Jan, Tsung-Hao Chang, I-Ming Jou, Pei-Shiuan Chen, Jui-Yen Lo, Shiang-Suo Huang, Nan-Shan Chang, Yung-Tsai Liou, Po-Chih Hsu, Hui-Ching Cheng, Yee-Shin Lin, Li-Jin Hsu   +14 more
doaj   +1 more source

Epidemiology of progressive intellectual and neurological deterioration in UK children

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 418-428, March 2026.
This study of PIND in UK children was carried out via the British Paediatric Surveillance Unit from 1997 to 2024. It identified six cases of vCJD. 2367 children had other diagnoses explain their deterioration. There were 259 other diseases in the diagnosed group.
Christopher M. Verity, Polly J. Maunder, Anne Marie Winstone, Suvankar Pal   +3 more
wiley   +1 more source

WWOX Suppresses Cell Growth and Induces Cell Apoptosis via Inhibition of P38 Nuclear Translocation in Cholangiocarcinoma

Cellular Physiology and Biochemistry, 2014
Background: Extrahepatic cholangiocarcinoma (EHCC) is the second most common primary hepatic malignancy, and is associated with high morbidity and mortality.
Mei Wang, Yongmei Li, Meihong Wu, Wei Wang, Biao Gong, Yajie Wang   +5 more
doaj   +1 more source

The insider's perspective: The intracellular complosome and immune cell dynamics in cancer

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Intracellular complement (complosome) shapes the tumour immune microenvironment. Complosome's role in cancer is underrecognised yet central to tumour immunity. C3/C5‐driven complosome signals rewire T‐cell activation, fate and metabolism. Complosome activity can promote pro‐tumour immune cell function.
Alexandra Bennion, Joanne Lysaght, Niamh Lynam‐Lennon   +2 more
wiley   +1 more source

The WWOX tumor suppressor gene in endometrial adenocarcinoma

International Journal of Molecular Medicine, 2013
Endometrial cancer is a lethal malignancy, the causes of which remain to be determined. The aim of the present study, carried out on tumor samples from 79 patients, was to evaluate the role of the WWOX tumor suppressor gene in endometrial adenocarcinoma.
Elżbieta, Płuciennik, Katarzyna, Kośla, Katarzyna, Wójcik-Krowiranda, Andrzej, Bieńkiewicz, Andrzej K, Bednarek   +4 more
openaire   +3 more sources

WWOX gene restoration prevents lung cancer growth in vitro and in vivo

, 2005
The WWOX (WW domain containing oxidoreductase) gene at the common fragile site, FRA16D, is altered in many types of cancer, including lung cancer. We have examined the tumor suppressor function of WWOX in preclinical lung cancer models. The WWOX gene was
AMADORI D., TRAPASSO F., AQEILAN R. I., HUEBNER K., FABBRI M., ILIOPOULOS D., YENDAMURI S., HAN S. Y., CIMMINO A., CROCE, Carlo Maria, ZANESI N.   +10 more
core   +1 more source

Cancerous Protein Network That Inhibits the Tumor Suppressor Function of WW Domain-Containing Oxidoreductase (WWOX) by Aberrantly Expressed Molecules

Frontiers in Oncology, 2018
Recent findings indicate that the WW domain-containing oxidoreductase (WWOX) is a tumor suppressor protein that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. WWOX protein mediates multiple signaling networks
Chiemi Saigo, Yusuke Kito, Tamotsu Takeuchi   +2 more
doaj   +1 more source

Endogenous Processes Underlying Clock‐Like Mutational Signatures

Genes, Chromosomes and Cancer, Volume 65, Issue 1, January 2026.
ABSTRACT Wellcome Trust scientists have shown that “mutational signatures” in specific nucleotide contexts accumulate in genomes of mammalian tissues, providing clues to underlying causes of specific signatures. Analysis of cancer genomes has identified more than 50 single‐base substitution (SBS) signatures, with SBS1, SBS5, and SBS40 linked to aging ...
Teresa Druck, Rami I. Aqeilan, C. Marcelo Aldaz, Nicola Zanesi, Kay Huebner   +4 more
wiley   +1 more source