Results 111 to 120 of about 1,108 (158)

Novel Hydrogel-Mediated Lentiviral Gene Delivery via Intravesical Administration for Bladder Cancer Treatment

Pharmaceutics
Background/Objectives: Bladder urothelial carcinoma is a frequent malignant tumor of the urinary system, characterized by its high rates of recurrence and resistance to chemotherapy.
Ching-Wen Liu, Po-Hen Chen, Kai-Jen Lin, Yu-Ting Cheng, Li-Ching Chang   +4 more
doaj   +1 more source

WWOX Drives T Leukemia Cell Maturation via IκBα/WWOX/ERK Signal Pathway

Journal of Tumor Research, 2017
Forced differentiation therapy has been shown to be effective in suppressing promyelocytic leukemia cell growth and other types of cancer cells in patients. A combination of calcium ionophore and phorbol ester is effective in inducing terminal maturation of T-cell acute lymphoblastic leukemia (T-ALL), in which it requires the signaling of IκBα/WWOX/ERK.
openaire   +1 more source

Zfra Overrides WWOX in Suppressing the Progression of Neurodegeneration

International Journal of Molecular Sciences
We reported that a 31-amino-acid Zfra protein (zinc finger-like protein that regulates apoptosis) blocks neurodegeneration and cancer growth. Zfra binds WW domain-containing oxidoreductase (WWOX) to both N- and C-termini, which leads to accelerated WWOX degradation.
Yu-An Chen, Tsung-Yun Liu, Kuan-Yu Wen, Che-Yu Hsu, Chun-I Sze, Nan-Shan Chang   +5 more
openaire   +2 more sources

Low expression of WW domain‐containing oxidoreductase associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection

Cancer Medicine, 2018
WW domain‐containing oxidoreductase (WWOX), which has a protein‐interaction domain and is regarded to be a tumor suppressor, has been known to play an important role in anti‐angiogenesis and cancer progression.
Chenhao Zhou, Wanyong Chen, Jialei Sun, Manar Atyah, Yirui Yin, Wentao Zhang, Lei Guo, Qinghai Ye, Qiongzhu Dong, Yi Shi, Ning Ren   +10 more
doaj   +1 more source

WWOX-Related Epileptic Encephalopathy (WOREE Syndrome): Clinical Case Study and Literature Review

Current Issues in Molecular Biology
The WW domain-containing oxidoreductase (WWOX) gene, well-known as a tumor suppressor, also has a crucial role as a transcription factor in the developing brain.
Annamaria Sapuppo, Roberta Rizzo, Gaia Fusto, Roberta Rocca, Vincenzo Sortino, Xena Giada Pappalardo, Martino Ruggieri, Raffaele Falsaperla   +7 more
doaj   +1 more source

Abstract 4303: Vopp1 physically interacts with Wwox and inhibits its apoptotic function in breast cancer

, 2017
WWOX is a tumor suppressor gene spanning the fragile site FRA16D and targeted by loss of heterozygosity or homozygous deletion in several tumor types. Wwox protein consists of two N-terminal WW domains that mediate protein-protein interactions and a C ...
Florian Bonin, Rosette Lidereau, François Lallemand, Keltouma Driouch   +3 more
core   +1 more source

WWOX (WW domain containing oxidoreductase) [PDF]

, 2007
Review on WWOX (WW domain containing oxidoreductase), with data on DNA, on the protein encoded, and where the gene is ...
Druck, Teresa, Hagrass, Hoda, Huebner, Kay   +2 more
core  

Additional file 3: of A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism

, 2019
Video S2. Migration of knockout Wwox−/− MEF cells as determined by time-lapse microscopy. Knockout Wwox −/−MEF cells were cultured in the right and left chambers of a culture-insert (ibidi) for 24 h.
Nan-Shan Chang (76035), Lori Schultz (76032), Sing-Ru Lin (257489), Chun-I Sze (257501), Pei-Yi Chou (6991742), Ming-Hui Lee (257492)   +5 more
core   +1 more source

Conditional KO of Wwox via BK5-Cre and MMTV-Cre.

, 2012
(A–F) Immunostaining of formalin-fixed histological sections of mammary glands from each model of deletion reveals strong cytoplasmic Wwox staining in WT samples and significant loss of Wwox protein expression in KO animals. (A) 8 week virgin BK5 Wwox WT,
Xinsheng Gao (167498), C. Marcelo Aldaz (167521), Fernando Benavides (29259), Martin C. Abba (167514), Brent W. Ferguson (167494), Jaeho Lee (167509), Hyunsuk Kil (167504)   +6 more
core   +1 more source

Location of coding sequence alterations of the WWOX gene.

, 2015
Location of coding sequence alterations of the WWOX gene.
Pelin Bulut (685421), Erkan Kilic (685423), Seda Ekizoglu (685420), Nur Buyru (685424), Emin Karaman (685422)   +4 more
core   +1 more source