Results 111 to 120 of about 5,637 (202)

miRNA Signature of Schwannomas: Possible Role(s) of “Tumor Suppressor” miRNAs in Benign Tumors [PDF]

, 2013
miRNAs have been recently implicated as drivers in several carcinogenic processes, where they can act either as oncogenes or as tumor suppressors. Schwannomas arise from Schwann cells, the myelinating cells of the peripheral nervous system.
Breakefield, Xandra Owens, Erkan, Erdogan Pekcan, Saydam, Okay   +2 more
core   +1 more source

Genetic etiologies with a large NGS panel in a monocentric cohort of 1000 patients with pediatric onset epilepsies

Epilepsia Open, Volume 10, Issue 4, Page 1065-1073, August 2025.
Abstract Objective Genetic testing is now included in the diagnostic assessment of childhood onset epilepsies. We evaluated the yield of a targeted next generation sequencing (TNGS) panel dedicated to pediatric epilepsies. Methods We tested by TNGS panel 1000 consecutive patients presenting with childhood onset epilepsies and including mainly patients ...
Giulia Barcia, Nicole Chemaly, Stéphanie Gobin‐Limballe, Emma Losito, Mélodie Aubart, Eugénie Sarda, Zahra Assouline, Pauline Plante‐Bordeneuve, Marie Hully, Remi Barrois, Christine Barnerias, Doxa Sareidaki, Delphine Coste Zeitoun, Monika Eisermann, Cécile Fourrage, Sylvain Hanein, Marlène Rio, Nathalie Boddaert, Isabelle Desguerre, Anna Kaminska, Julie Steffann, Rima Nabbout   +21 more
wiley   +1 more source

Modeling WWOX Loss of Function in vivo: What Have We Learned?

Frontiers in Oncology, 2018
The WW domain–containing oxidoreductase (WWOX) gene encompasses a common fragile sites (CFS) known as FRA16D, and is implicated in cancer. WWOX encodes a 46kDa adaptor protein, which contains two N-terminal WW–domains and a catalytic domain at its C ...
Mayur Tanna, Rami I. Aqeilan, Rami I. Aqeilan   +2 more
doaj   +1 more source

53BP1 can limit sister-chromatid rupture and rearrangements driven by a distinct ultrafine DNA bridging-breakage process [PDF]

, 2018
Chromosome missegregation acts as one of the driving forces for chromosome instability and cancer development. Here, we find that in human cancer cells, HeLa and U2OS, depletion of 53BP1 (p53-binding protein 1) exacerbates chromosome non-disjunction ...
A Biebricher, A Coquelle, A Janssen, A Moreno, A Xie, AM Casper, B McClintock, B Nera, B Wang, BA Weaver, BC Turner, C Baumann, C Escribano-Diaz, C Lengauer, C Lukas, D Jullien, F Ochs, H Wang, IM Ward, IM Ward, J Karlseder, J Maciejowski, J Maciejowski, JA Harrigan, JM Spence, JR Chapman, K Crasta, KL Chan, KL Chan, KL Chan, KL Chan, LC Funk, M Macville, M Schwartz, M Virgilio Di, M Zimmermann, MF Arlt, N Dimitrova, P Baumann, R Beroukhim, RA Burrell, RC Hengeveld, S Sengupta, S Ying, SF Bunting, SJ Xia, T Caspersson, T Davoli, T Taniguchi, TW Glover, V Naim, V Naim, V Tripathi, V Tripathi   +53 more
core   +2 more sources

Role of NTRK Fusion Genes in the Tumor Immune Microenvironment of HPV (+/−) Cervical Cancer

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT Cervical cancer, a prevalent gynecological malignancy, is primarily associated with human papillomavirus (HPV) infection. However, some cases display distinct molecular alterations beyond HPV, significantly impacting the tumor immune microenvironment (TIME) and posing therapeutic challenges.
Qiongying Wang, Chan Zhang, Shijia Liu, Wangshu Li, Wenjuan Wei, Aziz ur Rehman Aziz, Han Lu, Daqing Wang   +7 more
wiley   +1 more source

Introduction to a Thematic Issue for WWOX [PDF]

Experimental Biology and Medicine, 2015
Since its discovery in 2000, WW domain-containing oxidoreductase (WWOX, FOR or WOX1) has been considered as a tumor suppressor protein. Global research focus has been aimed mainly toward this direction. In this thematic issue, updated information has been collected regarding the structure, function and signaling of WWOX, along with its critical role ...
openaire   +1 more source

Characterization of 1-ACBP B-ACBP and PBR in oesophageal cancer [PDF]

, 2006
Faculty of Science; School of molecular and Cell Biology; MSC DissertationBackground: Cancer of the oesophagus ranks as the ninth most common malignancy in the world, and recent evidence shows that its incidence is increasing.
McCabe, Michelle Lynn
core  

Nuclear hyaluronidase 2 drives alternative splicing of CD44 pre-mRNA to determine profibrotic or antifibrotic cell phenotype [PDF]

, 2017
The cell surface protein CD44 is involved in diverse physiological processes, and its aberrant function is linked to various pathologies such as cancer, immune dysregulation, and fibrosis.
Hascall, Vincent, Meran, Soma, Midgley, Adam C., Oltean, Sebastian, Phillips, Aled O., Steadman, Robert, Woods, Emma L.   +6 more
core   +2 more sources

The role of AP-2 alpha in predicting response to chemotherapy in breast cancer patients [PDF]

, 2011
Breast cancer is the most frequent cancer occurring in women in Europe1. In Switzerland, the incidence in 2009 was 32,9% and it was the primary cause of cancer related death in women, with a mortality rate of 19.2%2. The management of this cancer depends
SICHITIU, J.
core  

FANCD2 facilitates replication through common fragile sites [PDF]

, 2016
Common fragile sites (CFSs) are genomic regions that are unstable under conditions of replicative stress. Although the characteristics of CFSs that render them vulnerable to stress are mainly associated with replication, the cellular pathways that ...
Aguilera López, Andrés, García Rubio, María Luisa, Herrera Moyano, Emilia, Madireddy, Advaitha, Olson, Susan, Owen, Nichole   +5 more
core   +1 more source