Results 101 to 110 of about 5,637 (202)

Long‐term outcomes of a cohort of patients with pharmacoresistant neonatal epilepsy and negative brain MRI

Epilepsia Open, Volume 10, Issue 5, Page 1605-1616, October 2025.
Abstract Objective Neonatal seizures initiate the onset of epilepsy in less than 20% of cases. Establishing accurate and prompt diagnosis for precision medicine, offering tailored care, and informing families about neurodevelopmental prognosis represents a significant challenge.
Thibault Beretti, William Rozalen, Laurent Villard, Florence Riccardi, Geraldine Daquin, Anne Lepine, Nathalie Villeneuve, Mathieu Milh, Béatrice Desnous   +8 more
wiley   +1 more source

Dissecting Intra-Tumor Heterogeneity by the Analysis of Copy Number Variations in Single Cells: The Neuroblastoma Case Study [PDF]

, 2019
Tumors often show intra-tumor heterogeneity because of genotypic differences between all the cells that compose it and that derive from it. Recent studies have shown significant aspects of neuroblastoma heterogeneity that may affect the diagnostic ...
Borrillo, Francesca, Cariati, Federica, D'Argenio, Valeria, Nunziato, Marcella, Shankar, Varun, Tomaiuolo, Rossella   +5 more
core   +1 more source

Ancestral genomic functional differences in oligodendroglia: implications for Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 9, September 2025.
Abstract INTRODUCTION This study investigates ancestry‐specific changes in induced pluripotent stem cell (iPSC)‐derived oligodendroglia genomic regulation in Alzheimer's disease (AD), addressing diversity gaps by including African, Amerindian, and European ancestries in the analysis. METHODS We generated 12 iPSC lines from AD patients and controls with
Aura M. Ramirez, Luciana Bertholim Nasciben, Sofia Moura, Lauren Coombs, Farid Rajabli, Brooke A. DeRosa, Patrice L. Whitehead, Larry D. Adams, Takiyah D. Starks, Pedro R. Mena, Maryenela Illanes‐Manrique, Sergio Tejada, Goldie S. Byrd, Allison Caban‐Holt, Michael L Cuccaro, Katalina McInerney, Mario R. Cornejo‐Olivas, Briseida E. Feliciano‐Astacio, Liyong Wang, Maria C. Robayo, Wanying Xu, Fulai Jin, Margaret A. Pericak‐Vance, Anthony J. Griswold, Juan I. Young, Derek M. Dykxhoorn, Jeffery M. Vance   +26 more
wiley   +1 more source

Alteration of WWOX in human cancer, a clinical view [PDF]

Experimental Biology and Medicine, 2015
WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3–24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors.
Izabela, Baryła, Ewa, Styczeń-Binkowska, Andrzej K, Bednarek   +2 more
openaire   +2 more sources

Cancerous Protein Network That Inhibits the Tumor Suppressor Function of WW Domain-Containing Oxidoreductase (WWOX) by Aberrantly Expressed Molecules

Frontiers in Oncology, 2018
Recent findings indicate that the WW domain-containing oxidoreductase (WWOX) is a tumor suppressor protein that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. WWOX protein mediates multiple signaling networks
Chiemi Saigo, Yusuke Kito, Tamotsu Takeuchi   +2 more
doaj   +1 more source

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer [PDF]

, 2019
BACKGROUND: Even though liver kinase B1 (LKB1) is usually described as a tumor suppressor in a wide variety of tissues, it has been shown that LKB1 aberrant expression is associated with bad prognosis in Hepatocellular Carcinoma (HCC).
Díaz Moreno, Irene, Díaz Quintana, Antonio Jesús, García Rodríguez, JL, Serrano Macía, M., Zubiete Franco, I   +4 more
core   +1 more source

Intermediate Conductance Calcium‐Dependent Potassium Channel (KCa3.1) Interacting Proteins Using Turboid‐Based Proximity Labeling Technology: Insights Into Interactome and Related Signaling Pathways in Pancreatic Tumors

Journal of Cellular Physiology, Volume 240, Issue 9, September 2025.
ABSTRACT KCa3.1 ion channel is a calcium‐activated potassium channel expressed in various tissues, showing dual localization to the plasma membrane and to mitochondria. This channel is highly expressed in numerous cancers and has been implicated in the regulation of proliferation and migration.
Veronica Carpanese, Soha Sadeghi, Luca Matteo Todesca, Ildikò Szabò, Vanessa Checchetto   +4 more
wiley   +1 more source

WWOX somatic ablation in skeletal muscles alters glucose metabolism

Molecular Metabolism, 2019
Objective: WWOX, a well-established tumor suppressor, is frequently lost in cancer and plays important roles in DNA damage response and cellular metabolism.
Muhannad Abu-Remaileh, Monther Abu-Remaileh, Rania Akkawi, Ibrahim Knani, Shiran Udi, Micheal E. Pacold, Joseph Tam, Rami I. Aqeilan   +7 more
doaj   +1 more source

Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ionizing radiation in DLD-1 cells [PDF]

, 2018
Indexación: Scopus.Departamento de Oncología Básico-Clínica, Facultad de Medicina, Universidad de Chile, Santiago, Chile 2Comisión Chilena de Energía Nuclear, Santiago, Chile 3Center for Research and Applications in Plasma Physics and Pulsed Power, P4 ...
Andaur, R., Armisen, R., Marcelain, K., Moreno, J., Soto, L., Tapia, J.C.   +5 more
core   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, Volume 12, Issue 29, August 7, 2025.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source