Results 101 to 110 of about 1,108 (158)

WWOX Mutation as a Rare Cause of Neonatal‐Infantile Parkinsonism Mimicking a Neurotransmitter Disorder: A Case Report

Journal of Paediatrics and Child Health, Volume 62, Issue 7, Page 1273-1277, July 2026.
Ozge Serce Pehlevan, Gizem Gider Yaman, Anıl Gok, Leman Tekin Orgun   +3 more
wiley   +1 more source

Konstrukter for ekspresjon av WWOX i mammalske celler

, 2007
Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter på kromosom 16q i ulike krefttyper.
Bækken, Siri
core  

Modeling WWOX Loss of Function in vivo: What Have We Learned?

Frontiers in Oncology, 2018
The WW domain–containing oxidoreductase (WWOX) gene encompasses a common fragile sites (CFS) known as FRA16D, and is implicated in cancer. WWOX encodes a 46kDa adaptor protein, which contains two N-terminal WW–domains and a catalytic domain at its C ...
Mayur Tanna, Rami I. Aqeilan, Rami I. Aqeilan   +2 more
doaj   +1 more source

Karakterisering av regulatoriske regioner oppstrøms for WWOX

, 2005
Det humane genet WWOX har blitt identifisert av flere uavhengige forskningsgrupper i forbindelse med studier av strukturelle abnormaliteter av kromosom 16q i ulike krefttyper.
Lindeberg, Mona Mari
core  

WWOX gene expression abolishes ovarian cancer tumorigenicity in vivo and decreases attachment to Fibronectin via Integrin alpha(3)

, 2009
The WW domain-containing oxidoreductase (WWOX) gene Is located at FRA16D, a common fragile site involved in human cancer. Targeted deletion of Wwox in mice causes increased spontaneous tumor incidence, confirming that WWOX is a bona fide tumor suppressor
Janczar, Szymon, Muir, Morwenna, Ward, Carol, Zhang, Jieqing, Sun, Mingjun, Paige, Adam J. W., Gabra, Hani, Kuske, Barbara, Taylor, Karen J., Smyth, John F., Paige, Adam, Gourley, Charlie, Harrison, David J., Harrison, David J.; id_orcid   +13 more
core   +1 more source

WWOX, tumour suppressor and modifier gene, as a regulator of gene expression and apoptosis in ovarian cancer [PDF]

, 2010
WWOX is a tumour suppressor gene, as demonstrated by increased neoplasia incidence in Wwox-knock-out animals, and is frequently disrupted in human cancers.
Janczar, Szymon Lech
core   +1 more source

Role of WWOX and Zfra in limiting neurodegeneration

The FASEB Journal, 2019
Human and animal newborns with WWOX / Wwox gene deficiency suffer severe neural diseases, seizure, microcephaly, metabolic disorders, and early death. Neuronal heterotopia, which accounts for seizure, occurs in the newborns due to enhanced migration of ...
Nan‐Shan Chang, Yu‐Hao Lin
openaire   +1 more source

Wwox And Ap2 Gamma Expression Levels Predict Tamoxifen Response

, 2007
Purpose: Assessment of expression levels of Wwox, Wwox- interacting proteins Ap2 alpha, Ap2 gamma, and ErbB4, the Ap2 gamma transcriptional target protein Her2, and the possible Ap2 alpha transcriptional target Prka Rl alpha, in breast cancers, to ...
Guler, Gulnur, Hayran, Mutlu, Iliopoulos, Dimitrios, Guler, Nilufer, Huebner, Kay, Himmetoglu, Cigdem   +5 more
core   +1 more source

B-cell–specific Wwox deletion promotes plasmablastic tumor development and proinflammatory signatures in myeloma model

Blood Neoplasia
: Deletions and translocations affecting WWOX accompanied by loss of expression are frequently observed in B-cell neoplasms and are linked to poor prognosis.
Tabish Hussain, Matthew D. Bramble, Bin Liu, Martin C. Abba, Marta Chesi, C. Marcelo Aldaz   +5 more
doaj   +1 more source

WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia

, 2018
Liver cancer is one of the most lethal malignancies with very poor prognosis once diagnosed. The most common form of liver cancer is hepatocellular carcinoma (HCC). The WW domain-containing oxidoreductase (WWOX) is a large gene that is often perturbed in
Muhannad Abu-Remaileh, Eli Pikarsky, Rami I. Aqeilan, Abed Khalaileh   +3 more
core   +1 more source