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WWOX: Its Genomics, Partners, and Functions
Journal of Cellular Biochemistry, 2009AbstractThe WW domain‐containing oxidoreductase (WWOX) spans one of the most active common fragile sites (CFSs) involved in cancer, FRA16D. WWOX encodes a 46‐kDa protein that contains two N‐terminal WW domains and a central short‐chain dehydrogenase/reductase (SDR) domain.
Rami I Aqeilan +2 more
exaly +3 more sources
Molecular Functions of WWOX Potentially Involved in Cancer Development
Cells, 2021 The WW domain-containing oxidoreductase gene (WWOX) was cloned 21 years ago as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. The localization of WWOX in a chromosomal region frequently altered in human cancers has initiated
François Lallemand, Rosette Lidereau
exaly +2 more sources
WWOX and Metabolic Regulation in Normal and Pathological Conditions
Journal of Molecular Medicine, 2022 AbstractWW domain-containing oxidoreductase (WWOX) spans the common fragile site FRA16D. There is evidence that translocations and deletions affecting WWOX accompanied by loss of expression are frequent in many cancers and often correlate with a worse prognosis.
Izabela Baryła +2 more
exaly +3 more sources
WWOX Loss of Function in Neurodevelopmental and Neurodegenerative Disorders [PDF]
International Journal of Molecular Sciences, 2020 The WWOX gene was initially discovered as a putative tumor suppressor. More recently, its association with multiple central nervous system (CNS) pathologies has been recognized. WWOX biallelic germline pathogenic variants have been implicated in spinocerebellar ataxia type 12 (SCAR12; MIM:614322) and in early infantile epileptic encephalopathy (EIEE28;
Tabish Hussain, C Marcelo Aldaz
exaly +3 more sources
Practical clues for diagnosing WWOX encephalopathy
Epileptic Disorders, 2017AbstractThe WW domain‐containing oxidoreductase gene is implicated in autosomal recessive disorders of the central nervous system, expressed either as spinocerebellar ataxia or as a severe form with early‐infantile epileptic encephalopathy. Here, we describe the electroclinical evolution of these disorders, adding new diagnostic clues based on a case ...
Oana, Tarta-Arsene +3 more
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WWOX Protein Expression in Normal Human Tissues [PDF]
Journal of Molecular Histology, 2006 WWOX is a putative tumor suppressor gene that spans approximately a 1 Mb genomic region and is the site for the second most common chromosomal fragile site, FRA16D at 16q23. Various studies have focused on the expression of WWOX in human cancer mostly at the RNA level, but little is known about the normal pattern of WWOX protein expression in non ...
C Marcelo Aldaz
exaly +3 more sources
Genetic alterations of the WWOX gene in breast cancer
Medical Oncology, 2011FRA3B and FRA16D are the most sensitive common chromosomal fragile site loci in the human genome and two tumor suppressor genes FHIT (Fragile Histidine Triad) and WWOX (WW domain-containing oxidoreductase gene) map to this sites. The WWOX gene is composed of 9 exons and encodes a 46-kD protein that contains 414 amino acids.
Ekizoglu, Seda +3 more
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Loss of WWOX expression in human extrahepatic cholangiocarcinoma
Journal of Cancer Research and Clinical Oncology, 2008WW domain-containing oxidoreductase (WWOX) is a tumor suppressor gene that maps to the common fragile site FRA16D on chromosome 16q23.3-24.1. To investigate the role of the WWOX gene in the development of extrahepatic cholangiocarcinoma (ECC), 30 tissue samples of ECC were examined.Loss of heterozygosity (LOH), real time reverse transcription PCR (RT ...
Mei, Wang +3 more
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Roles of FHIT and WWOX fragile genes in cancer
Cancer Letters, 2006It was hypothesized as early as 1986, that the recently discovered common fragile sites could facilitate recombination events, such as deletions and translocations, that result in clonally expanded cancer cell populations with specific chromosome alterations in specific cancer types.
Huebner, K +6 more
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