Results 161 to 170 of about 4,897 (187)

Advances in genetic developmental and epileptic encephalopathies with movement disorders. [PDF]

Acta Epileptol
Yuan M, Wang X, Yang Z, Luo H, Gan J, Luo R.   +5 more
europepmc   +1 more source

Identifying individuals with rare disease variants by inferring shared ancestral haplotypes from SNP array data. [PDF]

NAR Genom Bioinform
Robertson E, Grinton BE, Oliver KL, Fearnley LG, Hildebrand MS, Sadleir LG, Scheffer IE, Berkovic SF, Bennett MF, Bahlo M.   +9 more
europepmc   +1 more source

Měnglà Virus VP40 Localizes to the Nucleus and Impedes the RIG-I Signaling Pathway. [PDF]

Viruses
Sweeney Gibbons J, Thakur N, Komers E, Vogel OA, Chakraborty P, Tufariello JM, Basler CF.   +6 more
europepmc   +1 more source

Alzheimer’s disease risk gene Wwox protects against amyloid pathology through metabolic reprogramming

Lucas-Clarke HJ, Maddison DC, Amadio L, Buhl E, O’Hare K, Regnault C, Peters OM, Hodge JJL, Smith GA.   +8 more
europepmc   +1 more source

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Genetic alterations of the WWOX gene in breast cancer

Medical Oncology, 2011
FRA3B and FRA16D are the most sensitive common chromosomal fragile site loci in the human genome and two tumor suppressor genes FHIT (Fragile Histidine Triad) and WWOX (WW domain-containing oxidoreductase gene) map to this sites. The WWOX gene is composed of 9 exons and encodes a 46-kD protein that contains 414 amino acids.
Nur Buyru
exaly   +3 more sources

Helicobacter pylori infection promotes methylation of WWOX gene in human gastric cancer

Biochemical and Biophysical Research Communications, 2011
WW domain-containing oxidoreductase (WWOX), a tumor suppressor gene, was reported to be downregulated in gastric cancer and other tumors. However, the mechanism by which WWOX is inactivated remains unclear. In our study, methylation status of WWOX was determined by MSP and sequencing.
Jiaqin, Yan, Mingzhi, Zhang, Junhui, Zhang, Xiaobing, Chen, Xudong, Zhang   +4 more
exaly   +3 more sources

Roles of FHIT and WWOX fragile genes in cancer

Cancer Letters, 2006
It was hypothesized as early as 1986, that the recently discovered common fragile sites could facilitate recombination events, such as deletions and translocations, that result in clonally expanded cancer cell populations with specific chromosome alterations in specific cancer types.
Dimitrios, Iliopoulos, Gulnur, Guler, Shuang-Yin, Han, Teresa, Druck, Michelle, Ottey, Kelly A, McCorkell, Kay, Huebner   +6 more
openaire   +2 more sources

Methylation of WWOX gene promotes proliferation of osteosarcoma cells.

Journal of B.U.ON. : official journal of the Balkan Union of Oncology, 2021
To explore the effects of WW domain-containing oxidoreductase (WWOX) gene methylation on proliferation and apoptosis of osteosarcoma cells.A total of 51 patients with osteosarcoma confirmed by pathological examinations were enrolled as the observation group, while 49 cases with non-osteosarcoma diagnosed and treated in our hospital were randomly ...
Yang, Liu, Qingqing, Wang, Pengjie, Yu, Wei, Miao, Chuanchuan, Liu, Yongqiang, Pu, Chengwu, Zhang   +6 more
openaire   +1 more source

Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.

Molecular cancer research : MCR, 2003
The WW domain containing oxidoreductase (WWOX) gene was recently identified as a candidate tumor suppressor gene at a common fragile site, FRA16D. Because the fragile histidine triad (FHIT) gene, a tumor suppressor gene encompassing the most active, common fragile site FRA3B, is frequently deleted in various cancers, we evaluated the expression of WWOX
Hideshi Ishii, Andrea Vecchione, Yutaka Furukawa, Krittaya Sutheesophon, Shuang-Yin Han, Teresa Druck, Tamotsu Kuroki, Francesco Trapasso, Miki Nishimura, Yasushi Saito, Keiya Ozawa, Carlo M. Croce, Kay Huebner, and Yusuke Furukawa   +13 more
openaire   +3 more sources

WWOX, a Chromosomal Fragile Site Gene and its Role in Cancer

2006
Allelic imbalances affecting the long arm of chromosome 16 have been extensively reported in the literature as common abnormalities observed in various carcinoma types, As a result of loss of heterozygosity (LOH) studies in breast cancer, we delimited a genomic area within chromosome 16 that demonstrated the highest frequency of abnormalities. This led
D, Ramos, C M, Aldaz
openaire   +2 more sources