Low expression of WW domain‐containing oxidoreductase associates with hepatocellular carcinoma aggressiveness and recurrence after curative resection [PDF]
Cancer Medicine, 2018 WW domain‐containing oxidoreductase (WWOX), which has a protein‐interaction domain and is regarded to be a tumor suppressor, has been known to play an important role in anti‐angiogenesis and cancer progression.
Chenhao Zhou +10 more
doaj +6 more sources
Expression of WW Domain-Containing Oxidoreductase WOX1 in Human Nervous System Tumors [PDF]
Analytical Cellular Pathology, 2013 Background and ObjectiveS: We aimed to evaluate the expression levels of the tumor suppressor WOX1 in nervous system tumors and its co-expression with p53 and neurofibromatosis type 2/merlin (NF2) tumor suppressor gene products.
Ming-Fu Chiang +5 more
doaj +5 more sources
Functional genetic variant of WW domain-containing oxidoreductase (WWOX) gene is associated with hepatocellular carcinoma risk. [PDF]
PLoS ONE, 2017 BACKGROUND:Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Human WW domain-containing oxidoreductase (WWOX) gene has been identified as a tumor suppressor gene in multiple cancers.
Hsiang-Lin Lee +5 more
doaj +5 more sources
Cancerous Protein Network That Inhibits the Tumor Suppressor Function of WW Domain-Containing Oxidoreductase (WWOX) by Aberrantly Expressed Molecules [PDF]
Frontiers in Oncology, 2018 Recent findings indicate that the WW domain-containing oxidoreductase (WWOX) is a tumor suppressor protein that contains two N-terminal WW domains and a central short-chain dehydrogenase/reductase domain. WWOX protein mediates multiple signaling networks
Chiemi Saigo +2 more
doaj +5 more sources
Genome-wide identification and functional validation of the WW domain containing oxidoreductase gene associated with sleep duration [PDF]
Scientific ReportsIndividual differences in sleep duration have been reported, and genetic components of sleep duration have been identified showing various heritability.
Soriul Kim +8 more
doaj +4 more sources
The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism. [PDF]
Exp Biol Med (Maywood), 2015 The WW domain-containing oxidoreductase ( WWOX) encodes a tumor suppressor that is frequently altered in cancer. WWOX binds several proteins and thus is postulated to be involved in a variety of cellular processes. Interestingly, Wwox-knockout mice develop normally in utero but succumb to hypoglycemia and other metabolic defects early in life ...
Abu-Remaileh M, Aqeilan RI.
europepmc +5 more sources
Strategies of oncogenic microbes to deal with WW domain-containing oxidoreductase. [PDF]
Exp Biol Med (Maywood), 2015 WW domain-containing oxidoreductase (WWOX) is a well-documented tumor suppressor protein that controls growth, survival, and metastasis of malignant cells. To counteract WWOX’s suppressive effects, cancer cells have developed many strategies either to downregulate WWOX expression or to functionally inactivate WWOX.
Chang Y, Lan YY, Hsiao JR, Chang NS.
europepmc +5 more sources
Structural insights into the functional versatility of WW domain-containing oxidoreductase tumor suppressor. [PDF]
Exp Biol Med (Maywood), 2015 Recent work on WW domain-containing oxidoreductase (WWOX) tumor suppressor is beginning to shed new light on both the molecular mechanism of action of its WW domains as well as the contiguous catalytic domain. Herein, the structural basis underlying the ability of WW1 domain to bind to various physiological ligands and how the orphan WW2 tandem ...
Farooq A.
europepmc +5 more sources
Downregulation of WW domain-containing oxidoreductase leads to tamoxifen-resistance by the inactivation of Hippo signaling. [PDF]
Exp Biol Med (Maywood), 2019 Acquired tamoxifen-resistance is an important cause of death in patients with hormone-dependent breast tumors. Therefore, understanding the molecular mechanisms underlying the development of tamoxifen-resistance is critical for successful endocrine therapy.
Li J +7 more
europepmc +5 more sources
Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus [PDF]
Neurobiology of Disease, 2019 The association of WW domain-containing oxidoreductase WWOX gene loss of function with central nervous system (CNS) related pathologies is well documented.
Tabish Hussain +11 more
doaj +4 more sources