Results 41 to 50 of about 5,535 (193)

Signaling from membrane receptors to tumor suppressor WW domain-containing oxidoreductase

Experimental Biology and Medicine, 2010
The family of WW domain-containing proteins contains over 2000 members. The small WW domain module is responsible, in part, for protein/protein binding interactions and signaling. Many of these proteins are located at the membrane/cytoskeleton area, where they act as adaptors to receive signals from the cell surface.
Jean-Yun, Chang, Ruei-Yu, He, Hsin-Ping, Lin, Li-Jin, Hsu, Feng-Jie, Lai, Qunying, Hong, Shean-Jen, Chen, Nan-Shan, Chang   +7 more
openaire   +2 more sources

WWOX and Its Binding Proteins in Neurodegeneration

Cells, 2021
WW domain-containing oxidoreductase (WWOX) is known as one of the risk factors for Alzheimer’s disease (AD), a neurodegenerative disease. WWOX binds Tau via its C-terminal SDR domain and interacts with Tau phosphorylating enzymes ERK, JNK, and GSK-3β ...
Che-Yu Hsu, Kuan-Ting Lee, Tzu-Yu Sun, Chun-I. Sze, Shenq-Shyang Huang, Li-Jin Hsu, Nan-Shan Chang   +6 more
doaj   +1 more source

Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]

, 2019
Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y., Kankia, Ibrahim H., Langdon, Simon P., Paramasivan, Poornima   +3 more
core   +3 more sources

The ATF6-Met [67] Val substitution is associated with increased plasma cholesterol levels [PDF]

, 2009
Objective— Activating transcription factor 6 (ATF6) is a sensor of the endoplasmic reticulum stress response and regulates expression of several key lipogenic genes.
Ayoubi, T.A., Bruin, T.W., Feskens, E.J.M., Glembotski, C.C., Greevenbroek, M.M., Heldens, J., Hofker, M.H., Kallen, C.J., Kuusisto, J., Laakso, K., Meex, S.J., Pajukanta, P., Schalkwijk, C.G., Sinsheimer, J.S., Stehouwer, C.D., Taskinen, M.R., Thuerauf, D.J., Vlietinck, R., Weissglas-Volkov, D., Wouters, B.G.   +19 more
core   +1 more source

JNK1 Physically Interacts with WW Domain-containing Oxidoreductase (WOX1) and Inhibits WOX1-mediated Apoptosis [PDF]

Journal of Biological Chemistry, 2003
Transient activation of c-Jun N-terminal kinase (JNK) promotes cell survival, whereas persistent JNK activation induces apoptosis. Bovine testicular hyaluronidase PH-20 activates JNK1 and protects L929 fibroblasts from staurosporine-mediated cell death.
Nan-Shan, Chang, Joan, Doherty, Amy, Ensign   +2 more
openaire   +2 more sources

Functional genomics with a comprehensive library of transposon mutants for the sulfate-reducing bacterium Desulfovibrio alaskensis G20. [PDF]

, 2014
UnlabelledThe genomes of sulfate-reducing bacteria remain poorly characterized, largely due to a paucity of experimental data and genetic tools. To meet this challenge, we generated an archived library of 15,477 mapped transposon insertion mutants in the
Arkin, Adam P, Davis, Ronald W, Deutschbauer, Adam, Esquivel, Zuelma, Hazen, Terry C, Kazakov, Alexey E, Kuehl, Jennifer V, Kuehn, Raquel, Nguyen, Michelle, Price, Morgan N, Ray, Jayashree, Wetmore, Kelly M   +11 more
core   +2 more sources

Members of the chloride intracellular ion channel protein family demonstrate glutaredoxin-like enzymatic activity [PDF]

, 2015
© 2015 Al Khamici et al. The Chloride Intracellular Ion Channel (CLIC) family consists of six evolutionarily conserved proteins in humans. Members of this family are unusual, existing as both monomeric soluble proteins and as integral membrane proteins ...
Brown, LJ, Cornell, BA, Curmi, PMG, Daniel, EL, Davey, MW, Hare, JE, Hossain, KR, Hudson, AL, Khamici, HA, Ng, JPM, Sinclair-Burton, AA, Valenzuela, SM   +11 more
core   +1 more source

Transposon and deletion mutagenesis of genes involved in perchlorate reduction in Azospira suillum PS. [PDF]

, 2013
UnlabelledAlthough much work on the biochemistry of the key enzymes of bacterial perchlorate reduction, chlorite dismutase, and perchlorate reductase has been published, understanding of the molecular mechanisms of this metabolism has been somewhat ...
Clark, Iain C, Coates, John D, Liao, Annette, Melnyk, Ryan A   +3 more
core   +2 more sources

Tumor suppressor WWOX and p53 alterations and drug resistance in glioblastomas

Frontiers in Oncology, 2013
Tumor suppressor p53 are frequently mutated in glioblastomas (GBMs) and appears to contribute, in part, to resistance to temozolomide and therapeutic drugs.
Ming-Fu eChiang, Pei-Yi eChou, Wan-Jen eWang, Chun-I eSze, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang, Nan-Shan eChang   +7 more
doaj   +1 more source

Loss of Wwox Perturbs Neuronal Migration and Impairs Early Cortical Development

Frontiers in Neuroscience, 2020
Mutations in the WWOX gene cause a broad range of ultra-rare neurodevelopmental and brain degenerative disorders, associated with a high likelihood of premature death in animal models as well as in humans.
Michele Iacomino, Simona Baldassari, Yuki Tochigi, Katarzyna Kośla, Francesca Buffelli, Annalaura Torella, Annalaura Torella, Mariasavina Severino, Dario Paladini, Luana Mandarà, Antonella Riva, Marcello Scala, Marcello Scala, Ganna Balagura, Ganna Balagura, Andrea Accogli, Andrea Accogli, Vincenzo Nigro, Vincenzo Nigro, Carlo Minetti, Carlo Minetti, Ezio Fulcheri, Ezio Fulcheri, Federico Zara, Federico Zara, Andrzej K. Bednarek, Pasquale Striano, Pasquale Striano, Hiroetsu Suzuki, Vincenzo Salpietro, Vincenzo Salpietro, Vincenzo Salpietro   +31 more
doaj   +1 more source