Results 61 to 70 of about 5,535 (193)

Wwox Deficiency Causes Downregulation of Prosurvival ERK Signaling and Abnormal Homeostatic Responses in Mouse Skin

Frontiers in Cell and Developmental Biology, 2020
Deficiency of tumor suppressor WW domain-containing oxidoreductase (WWOX) in humans and animals leads to growth retardation and premature death during postnatal developmental stages. Skin integrity is essential for organism survival due to its protection
Ying-Tsen Chou, Feng-Jie Lai, Feng-Jie Lai, Nan-Shan Chang, Nan-Shan Chang, Li-Jin Hsu, Li-Jin Hsu   +6 more
doaj   +1 more source

HOXD8 exerts a tumor-suppressing role in colorectal cancer as an apoptotic inducer [PDF]

, 2017
Homeobox (HOX) genes are conserved transcription factors which determine the anterior-posterior body axis patterning. HOXD8 is a member of HOX genes deregulated in several tumors such as lung carcinoma, neuroblastoma, glioma and colorectal cancer (CRC ...
Mansour, Mohammed A., Senga, Takeshi
core   +1 more source

The Structure of Carboxyl Methyltransferase Provides Insights Into the Substrate Specificity and Divergent Evolution of Iridoid

Plant Biotechnology Journal, EarlyView.
ABSTRACT Iridoids constitute a prominent class of plant‐specialised metabolites, with carbocyclic iridoids (e.g., geniposide) and secoiridoids (e.g., loganin) diverging early in their biosynthetic pathways. This divergence is marked by substrate‐specific carboxyl methyltransferases—GjGAMT and CrLAMT—that catalyse the decisive methylation step in ...
Li Li, Zhiteng Luo, Zhaoyin He, Jie Tang, Wuke Wei, Ruoting Zhan, Huihao Zhou, Dongming Ma   +7 more
wiley   +1 more source

VOPP1 promotes breast tumorigenesis by interacting with the tumor suppressor WWOX

BMC Biology, 2018
Background The WW domain-containing oxidoreductase (WWOX) gene, frequently altered in breast cancer, encodes a tumor suppressor whose function is mediated through its interactions with cancer-related proteins, such as the pro-apoptotic protein p73α ...
Florian Bonin, Karim Taouis, Paula Azorin, Ambre Petitalot, Zakia Tariq, Sebastien Nola, Nadège Bouteille, Sandrine Tury, Sophie Vacher, Ivan Bièche, Khadija Ait Rais, Gaelle Pierron, Laetitia Fuhrmann, Anne Vincent-Salomon, Etienne Formstecher, Jacques Camonis, Rosette Lidereau, François Lallemand, Keltouma Driouch   +18 more
doaj   +1 more source

Artificial Intelligence Powers Protein Functional Annotation

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This review systematically summarizes how artificial intelligence advances protein functional annotation. It organizes existing methods into six unified modeling paradigms and analyzes their applications in Gene Ontology and Enzyme Commission prediction.
Wenkang Wang, Qiurong Yang, Min Zeng, Ruiqing Zheng, Min Li   +4 more
wiley   +1 more source

WW Domain‐containing Oxidoreductase Induces Cellular Senescence in Response to Replication Stress

The FASEB Journal, 2018
The induction of DNA damage response (DDR) to ensure accurate duplication of genetic information is crucial for the maintenance of cellular genome integrity during DNA replication. Under replication stress, cellular senescence is a DDR mechanism that prevents the proliferation of cells with DNA damage to avoid mitotic anomalies and
Hui‐Ching Cheng, Li‐Jin Hsu
openaire   +1 more source

Novel Hydrogel-Mediated Lentiviral Gene Delivery via Intravesical Administration for Bladder Cancer Treatment

Pharmaceutics
Background/Objectives: Bladder urothelial carcinoma is a frequent malignant tumor of the urinary system, characterized by its high rates of recurrence and resistance to chemotherapy.
Ching-Wen Liu, Po-Hen Chen, Kai-Jen Lin, Yu-Ting Cheng, Li-Ching Chang   +4 more
doaj   +1 more source

Systematic analysis of expression signatures of neuronal subpopulations in the VTA

Molecular Brain, 2019
Gene expression profiling across various brain areas at the single-cell resolution enables the identification of molecular markers of neuronal subpopulations and comprehensive characterization of their functional roles.
Hyun Jin Kim, Minhyung Kim, Byeongsoo Kang, Soyeon Yun, Shin Eun Ryeo, Daehee Hwang, Joung-Hun Kim   +6 more
doaj   +1 more source

Characterization of WWOX expression and function in canine mast cell tumors and malignant mast cell lines

BMC Veterinary Research, 2020
Background The WW domain-containing oxidoreductase (WWOX) tumor suppressor gene is frequently lost in a variety of solid and hematopoietic malignancies in humans. Dysregulation of WWOX has been implicated as playing a key role in tumor cell survival, DNA
Rebecca Makii, Hanna Cook, Darian Louke, Justin Breitbach, Ryan Jennings, Christopher Premanandan, Eric M. Green, Joelle M. Fenger   +7 more
doaj   +1 more source

Influence of the molybdenum cofactor biosynthesis on anaerobic respiration, biofilm formation and motility in Burkholderia thailandensis [PDF]

, 2014
types: Journal Article; Research Support, Non-U.S. Gov'tCopyright © 2013 Institut Pasteur. Published by Elsevier Masson SAS.Elsevier. NOTICE: This is the author’s version of a work accepted for publication by Elsevier.
Andreae, Clio A., Butler, Clive S, Titball, Richard W.   +2 more
core   +1 more source