Results 81 to 90 of about 5,535 (193)

Genetic and Functional Evidence Links Germline Biallelic Inactivating Variants in WWOX to Histological Mixed‐Type Thyroid Cancer

Advanced Science, Volume 13, Issue 1, 5 January 2026.
The role of germline WWOX loss‐of‐function variants in oncogenesis has remained poorly characterized. This study provides the first comprehensive genetic and functional evidence that such variants promote tumorigenesis through the disruption of multiple tumor‐suppressive mechanisms.
Xiaopeng Zhang, Jian Qi, Jialiang Wang, Zhipeng Wang, Yongguang Wang, Zongtao Hu, Ao Xu, Bo Hong, Hongzhi Wang   +8 more
wiley   +1 more source

WW domain-containing oxidoreductase WOX1 is upregulated in certain types of central nervous system tumors

Journal of Neuropathology and Experimental Neurology, 2007
WOX1 is frequently upregulated, along with increased Tyr33 phosphorylation (p‐WOX1), during progression of breast, prostate and probably other types of cancers to a pre‐metastatic stage. In contrast, invasive or metastatic cells loss WOX1 expression.
Chun-I Sze, Ming-Fu Chiang, Shur-Tzu Chen, Nan-Shan Chang   +3 more
openaire   +2 more sources

Influence of WWOX/MAF genes on cognitive performance in patients with Parkinson's disease

Neurobiology of Disease
Background: Beyond its hallmark motor symptoms, Parkinson's disease (PD) encompasses a range of non-motor disturbances, particularly cognitive impairment, which significantly affects patients' quality of life. Cognitive impairment is a shared manifest in
Yun-Ting Yuan, Wei-Pin Hong, Chun-Hsiang Tan, Rwei-Ling Yu   +3 more
doaj   +1 more source

A predicted physicochemically distinct sub-proteome associated with the intracellular organelle of the anammox bacterium Kuenenia stuttgartiensis [PDF]

, 2010
Medema MH, Zhou M, van Hijum SAFT, et al. A predicted physicochemically distinct sub-proteome associated with the intracellular organelle of the anammox bacterium Kuenenia stuttgartiensis. BMC Genomics.
Marnix H. Medema, Miaomiao Zhou, Sacha A.F.T. van Hijum, Jolein Gloerich, Hans J.C.T Wessels, Roland J. Siezen, Marc Strous   +6 more
core   +3 more sources

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen, Yiming Huang, Yang Zhang, Chunhao Yu, Hanqi Liu, Dong Bian, Di Wu, Wu Wang, Xunming Ji, Yufeng Zheng, Miaowen Jiang, Ming Li   +11 more
wiley   +1 more source

Genome-wide association analysis to identify QTL for carcass traits in Hanwoo (Korean native cattle)

Indian Journal of Animal Sciences, 2019
A genome-wide association study (GWAS) was performed to investigate the genetic markers associated with carcass traits of Hanwoo (Bos taurus coreanae) steer in the Gangwon region of Korea.
MIN-WOOK HONG, SO-YOUNG CHOI, NARESH KUMAR SINGH, HUN KIM, SONG-YI YANG, KYEONGROK KWAK, JONG-BOK KIM, SUNG-JIN LEE   +7 more
doaj   +1 more source

WWOX Mutation as a Rare Cause of Neonatal‐Infantile Parkinsonism Mimicking a Neurotransmitter Disorder: A Case Report

Journal of Paediatrics and Child Health, EarlyView.
Ozge Serce Pehlevan, Gizem Gider Yaman, Anıl Gok, Leman Tekin Orgun   +3 more
wiley   +1 more source

Functionalizing Nucleic Acids: Synthesis and Purification Strategies for Bioconjugates as Biomaterials

Small, Volume 22, Issue 5, 22 January 2026.
Nucleic acid‐ligand conjugates combine the distinct properties of macromolecular ligands with the versatility of DNA/RNA nanotechnology. In biomaterial and nanomedicine applications, highly purified products are paramount, requiring reliable synthesis and purification methods.
Nico Alleva, Jian Zhang, David Y. W. Ng, Tanja Weil, Torsten John   +4 more
wiley   +1 more source

A genome-wide association study on hematopoietic stem cell transplantation reveals novel genomic loci associated with transplant outcomes

Frontiers in Immunology
IntroductionData on genomic susceptibility for adverse outcomes after hematopoietic stem cell transplantation (HSCT) for recipients are scarce.MethodsWe performed a genome wide association study (GWAS) to identify genes associated with survival/mortality,
Albert Rosenberger, Rachel E. Crossland, Ralf Dressel, Dieter Kube, Daniel Wolff, Gerald Wulf, Heike Bickeböller, Anne Dickinson, Ernst Holler   +8 more
doaj   +1 more source

PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome

Scientific Reports, 2017
The long non-coding RNA PARTICLE (Gene PARTICL- ‘Promoter of MAT2A-Antisense RadiaTion Induced Circulating LncRNA) partakes in triple helix (triplex) formation, is transiently elevated following low dose irradiation and regulates transcription of its ...
Valerie Bríd O’Leary, Jan Smida, Fabian Andreas Buske, Laura Garcia Carrascosa, Omid Azimzadeh, Doris Maugg, Sarah Hain, Soile Tapio, Wolfgang Heidenreich, James Kerr, Matt Trau, Saak Victor Ovsepian, Michael John Atkinson   +12 more
doaj   +1 more source