Results 71 to 80 of about 5,535 (193)

Exosomal Non‐Coding RNAs in Gastrointestinal Cancer Drug Resistance: A Systematic Review of Emerging Mechanisms and Clinical Implications

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Gastrointestinal (GI) tumours are one of the most prevalent cancers globally. Even with normal GI function, individuals may develop neoplasms, highlighting the need to better understand the underlying causes of tumorigenesis. The emergence of tumour drug resistance represents the main reason for the failure of drug treatment; thus, it is ...
Mohsen Sharif‐zak, Zahra Sadeghloo, Fateme Binayi, Stefania Nobili, Sara Ashtari, Amir Sadeghi, Nayeralsadat Fatemi   +6 more
wiley   +1 more source

Equipped for success: genomes and metabolomes of the European Amanita muscaria are conserved in its novel South African range

New Phytologist, Volume 250, Issue 3, Page 1863-1883, May 2026.
Summary Plants and soils have been moved around the world for centuries, but invasive mushrooms receive scant attention. The Amanita muscaria species complex was introduced to South Africa in the context of forestry, but its origins, ecology and recent evolution are unstudied. We sequenced the genomes of 24 Northern and Southern Hemisphere A. muscaria,
Grant R. Nickles, Cecelia K. Stokes, Deborah L. Narh, Kira M. T. Lynn, Savannah R. Fuqua, Corbin Bryan, Brooke M. Allen, Christopher P. Bivins, Jin Woo Bok, J. Stephen Brewer, Sikelela T. Buthelezi, Jahiya P. R. M. Clark, Kerri L. Coon, Lauren R. Corby, Martin P. A. Coetzee, Claudette Dewing, Tuan A. Duong, Mathew A. Harris, Nancy P. Keller, Katlego Kopotsa, Frances A. Lane, Holly L. Nichols, Alandie Nieuwoudt, Martin A. Nuñez, Miguel E. Medina Munoz, Sung Chul Park, Nam Q. Pham, Kaetlyn T. Ryan, Myriam Solís, Rytas Vilgalys, Jasmine Marea Wallace, Yen‐Wen Wang, Brenda D. Wingfield, Michael J. Wingfield, Travis K. Worley, Taylor A. Zallek, Mostafa Zamanian, Jason D. Hoeksema, Milton T. Drott, Anne Pringle   +39 more
wiley   +1 more source

In vitro and in silico assessment of the effect of WWOX expression on invasiveness pathways associated with AP-2 transcription factors in bladder cancer

BMC Urology, 2021
Background WW Domain Containing Oxidoreductase (WWOX) belongs to the unusual tumor suppressors, whose molecular function is not fully understood in bladder cancer, especially regarding interaction with Activator Protein 2 (AP-2) α/γ transcription factors.
Żaneta Kałuzińska, Damian Kołat, Katarzyna Kośla, Magdalena Orzechowska, Andrzej K. Bednarek, Elżbieta Płuciennik   +5 more
doaj   +1 more source

Regulation of mitochondrial permeability transition pore by PINK1 [PDF]

, 2012
Background: Loss-of-function mutations in PTEN-induced kinase 1 (PINK1) have been linked to familial Parkinson’s disease, but the underlying pathogenic mechanism remains unclear.
Caballero, Erica, Chan, David, Gautier, Clemente A., Glaime, Emilie, Núñez, Lucía, Shen, Jie, Song, Zhiyin, Villalobos, Carlos   +7 more
core   +3 more sources

Asymmetric Cu─N─Ru Bridgedsite Nanozyme‐Loaded Injectable Thermogel Boosts Cuproptosis‐Like Death for Multidrug‐Resistant Urinary Tract Infections

Advanced Science, Volume 13, Issue 19, 2 April 2026.
To address multidrug‐resistant urinary tract infections (MDR‐UTIs), we developed Cu‐ZIF8‐Ru nanozyme featuring an asymmetric Cu─N─Ru catalytic site. This unique structure enhances multienzyme‐mimetic activity, eradicating resistant bacteria by inducing a cuproptosis‐like death pathway through intracellular Cu2+ accumulation and energy depletion.
Guanlin Li, Shike Zhang, Jinggong Liu, Xin Wang, Heng Wang, Hongcan Yang, Yuhao Zhou, Wen Liu, Hongxing Liu, Wenqi Wu   +9 more
wiley   +1 more source

Novel homozygous mutation in the WWOX gene causes seizures and global developmental delay: Report and review

Translational Neuroscience, 2018
The WWOX gene has a WW domain containing oxidoreductase, which is located at the common fragile site FRA16D at chromosome 16q23. WWOX is a tumor suppressor gene that has been associated with several types of cancer such as hepatic, breast, lung, prostate,
Ehaideb Salleh N., Al-Bu Ali Majed J., Al-obaid Jaafer J., Aljassim Kareemah M., Alfadhel Majid   +4 more
doaj   +1 more source

Mitochondrial dysfunction in hereditary optic neuropathies [PDF]

, 2009
MITOCHONDRIAL DYSFUNCTION IN HEREDITARY OPTIC NEUROPATHIES Mitochondrial pathologies are a heterogeneous group of clinical manifestations characterized by oxidative phosphorylation impairment.
Casalena, Gabriella Assunta <1980>
core   +1 more source

Study on the Function and Mechanism of Neutrophil Extracellular Traps in Regulating Necroptosis Following Traumatic Brain Injury

Brain and Behavior, Volume 16, Issue 3, March 2026.
TBI induces NETs formation, as evidenced by the upregulation of PAD4 and MPO. NETs activate the necroptosis pathway via phosphorylation of RIP1‐RIP3‐MLKL, thereby exacerbating secondary brain injury (neuronal death, BBB disruption, and neuroinflammation).
Ao Li, Tian‐Wei Pei, Hao Qi, Li‐Biao Song, Juan Fang, Zhi‐Song Ding, Tao Chen   +6 more
wiley   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, Volume 13, Issue 10, 18 February 2026.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

Global transcriptome response in during growth on ribose [PDF]

, 2011
Background Lactobacillus sakei is valuable in the fermentation of meat products and exhibits properties that allow for better preservation of meat and fish. On these substrates, glucose and ribose are the main carbon sources available for growth. We used
Naterstad Kristine, Snipen Lars, McLeod Anette, Axelsson Lars   +3 more
core   +2 more sources