Results 51 to 60 of about 5,535 (193)

The Role of DNA Methyltransferases in Urinary System Diseases. [PDF]

Cancer Innov
Multiple signaling pathways mediated by DNMTs in the formation of renal fibrosis: (a) DNMTs suppress the expression of transcription factor KLF4 by mediating promoter hypermethylation, thereby promoting epithelial–mesenchymal transition and contributing to the development of renal fibrosis; (b) oxidative stress can upregulate the levels of DNMTs, which
Dong W, Pei S, Zhu D, Zeng C, Qiu Y, Wu Y, Jia X, Zhang S, Li C, Zhang W, Zhang W, Chen Z.   +11 more
europepmc   +2 more sources

The Urea Carboxylase and Allophanate Hydrolase Activities of Urea Amidolyase Are Functionally Independent [PDF]

, 2016
Urea amidolyase (UAL) is a multifunctional biotin-dependent enzyme that contributes to both bacterial and fungal pathogenicity by catalyzing the ATP-dependent cleavage of urea into ammonia and CO2.
Bahler, Baker, Balotra, Bratlie, Chapman-Smith, Chen, Chen, Cheng, Dumetz, Fan, Fan, Geck, Ghosh, Greenberg, Hettwer, Huang, Ianeselli, James, Kaessmann, Kanamori, Kanamori, Khosla, Kimura, Koonin, Kotlyar, Kozer, Kulkarni, Kulkarni, Kuriyan, Lawrence, Lherbet, Lietzan, Lin, Lorenz, Marsh, Moxley, Navarathna, Navarathna, Ribeiro, Shapir, Shapir, Singh, Spivey, Strope, Thanabalu, Thoden, Thompson, Whitney, Zeczycki   +48 more
core   +2 more sources

WW Domain‐containing Oxidoreductase Regulates Keratinocyte Growth for Maintaining Epidermal Homeostasis

The FASEB Journal, 2018
Human fragile WWOX gene encodes a candidate tumor suppressor WW domain‐containing oxidoreductase. Previous studies have shown that ectopically overexpressed WWOX induces apoptosis in cancer cells and suppresses tumor growth both in vitro and
Ying‐Tsen Chou, Li‐Jin Hsu
openaire   +1 more source

WWOX Modulates ROS-Dependent Senescence in Bladder Cancer

Molecules, 2022
The tumor-suppressor gene, WW domain-containing oxidoreductase (WWOX), has been found to be lost in various types of cancers. ROS result as a tightly regulated signaling process for the induction of cell senescence.
Ching-Wen Liu, Po-Hen Chen, Tsan-Jung Yu, Kai-Jen Lin, Li-Ching Chang   +4 more
doaj   +1 more source

Fnr (EtrA) acts as a fine-tuning regulator of anaerobic metabolism in Shewanella oneidensis MR-1 [PDF]

, 2011
BackgroundEtrA in Shewanella oneidensis MR-1, a model organism for study of adaptation to varied redox niches, shares 73.6% and 50.8% amino acid sequence identity with the oxygen-sensing regulators Fnr in E.
Claribel Cruz-García, Alison E Murray, Jorge LM Rodrigues, Jeffrey A Gralnick, Lee McCue, Margaret F Romine, Frank E Löffler, James M Tiedje   +7 more
core   +2 more sources

Immunohistochemical WWOX Expression and Association with Angiogenesis, p53 Expression, Cell Proliferation and Clinicopathological Parameters in Cervical Cancer [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2018
Objective The current study evaluated the expression of WW domain-containing oxidoreductase (WWOX), its association with clinicopathological features and with p53, Ki-67 (cell proliferation) and CD31 (angiogenesis) expression in patients with invasive ...
Mariana Ataydes Leite Seabra, Eduardo Batista Cândido, Paula Vieira Teixeira Vidigal, Rivia Mara Lamaita, Angélica Nogueira Rodrigues, Agnaldo Lopes da Silva Filho   +5 more
doaj   +2 more sources

EHBP1, TUBB, and WWOX SNPs, Gene-Gene and Gene-Environment Interactions on Coronary Artery Disease and Ischemic Stroke

Frontiers in Genetics, 2022
The associations among the EH domain-binding protein 1 (EHBP1), tubulin beta class I (TUBB), and WW domain-containing oxidoreductase (WWOX) single nucleotide polymorphisms (SNPs) and coronary artery disease (CAD) and ischemic stroke (IS) are not yet ...
Chun-Xiao Liu, Rui-Xing Yin, Xiao-Li Cao, Zong-Hu Shi, Feng Huang, Bi-Liu Wei, Guo-Xiong Deng, Peng-Fei Zheng, Yao-Zong Guan   +8 more
doaj   +1 more source

Neurological Disorders Associated with WWOX Germline Mutations—A Comprehensive Overview

Cells, 2021
The transcriptional regulator WW domain-containing oxidoreductase (WWOX) is a key player in a number of cellular and biological processes including tumor suppression. Recent evidence has emerged associating WWOX with non-cancer disorders.
Ehud Banne, Baraa Abudiab, Sara Abu-Swai, Srinivasa Rao Repudi, Daniel J. Steinberg, Diala Shatleh, Sarah Alshammery, Leszek Lisowski, Wendy Gold, Peter L. Carlen, Rami I. Aqeilan   +10 more
doaj   +1 more source

The oxygen-independent metabolism of cyclic monoterpenes in Castellaniella defragrans 65Phen [PDF]

, 2014
BACKGROUND: The facultatively anaerobic betaproteobacterium Castellaniella defragrans 65Phen utilizes acyclic, monocyclic and bicyclic monoterpenes as sole carbon source under oxic as well as anoxic conditions.
Becher, D., Disch, E., Harder, J., Huettel, B., Markert, S., Petasch, J., Reinhardt, R., Schweder, T.   +7 more
core   +2 more sources

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

, 2013
Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Alex Dyson, Audibert G, Berne RM, Blitzer ML, Boutilier RG, Brown IP, Devlin C, Furukawa K, Hall JE, Heyes MP, Jekabsone A, Lehninger A, Leone AM, Louis CA, Martin Feelisch, Mervyn Singer, Michele Umbrello, Modin A, Munk VC, Pohl U, Rengasamy A, Rengasamy A, Vallance P, Whorton AR   +23 more
core   +1 more source