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Shape‐Morphing Nanoengineered Hydrogel Ribbons as Hemostats
Advanced Functional Materials, EarlyView.This study introduces a self‐assembling, shape‐morphing nanoengineered hydrogel ribbon system that rapidly forms porous aggregates in situ for efficient hemostasis in trauma and surgical applications. Abstract Rapid and effective hemorrhage control remains a major challenge in trauma and surgical care, particularly for complex or noncompressible wounds.
Ryan Davis Jr +9 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Tumor‐tropic human mesenchymal stem cells (hMSCs) were used as delivery vehicles for magnetotheranostic gold–iron oxide nanoflowers. Magnetic particle imaging of the iron component demonstrated widespread intratumoral distribution and sustained retention in contrast to injection of naked nanoflowers.
Behnaz Ghaemi +7 more
wiley +1 more source
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Current Opinion in Genetics & Development, 2007
Random inactivation of one of the two female X chromosomes establishes dosage compensation between XY males and XX females in placental mammals. X inactivation is controlled by the X inactivation center (Xic). Recent advances in genome sequencing show that the Xic has evolved from an ancestral vertebrate gene cluster in placental mammals and has ...
Wutz, A, Gribnau, Joost
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Random inactivation of one of the two female X chromosomes establishes dosage compensation between XY males and XX females in placental mammals. X inactivation is controlled by the X inactivation center (Xic). Recent advances in genome sequencing show that the Xic has evolved from an ancestral vertebrate gene cluster in placental mammals and has ...
Wutz, A, Gribnau, Joost
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Cytogenetic and Genome Research, 2002
Although the process of X inactivation in mammalian cells silences the majority of genes on the inactivated X chromosome, some genes escape this chromosome-wide silencing. Genes that escape X inactivation present a unique opportunity to study the process of silencing and the mechanisms that protect some genes from being turned off.
C M, Disteche +2 more
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Although the process of X inactivation in mammalian cells silences the majority of genes on the inactivated X chromosome, some genes escape this chromosome-wide silencing. Genes that escape X inactivation present a unique opportunity to study the process of silencing and the mechanisms that protect some genes from being turned off.
C M, Disteche +2 more
openaire +2 more sources
Seminars in Cell & Developmental Biology, 2010
X inactivation is the mechanism by which mammals adjust the X-linked gene dosage between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in female cells. This dosage-compensation mechanism is based on the long functional Xist RNA.
Ruben, Agrelo, Anton, Wutz
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X inactivation is the mechanism by which mammals adjust the X-linked gene dosage between the sexes. The dosage difference between XX females and XY males is functionally equalized by silencing one of the two X chromosomes in female cells. This dosage-compensation mechanism is based on the long functional Xist RNA.
Ruben, Agrelo, Anton, Wutz
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Science, 2000
Inactivation of one of the two X chromosomes occurs in all cells of female adult mice so that genes are expressed from only one X chromosome. In a Perspective, [Clerc and Avner][1] describe an elegant series of experiments in mouse embryos cloned from adult and embryonic female cell nuclei ([ Eggan et al. ][2]) that reveal how the inactivation state of
Philippe Clerc, Philip Avner
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Inactivation of one of the two X chromosomes occurs in all cells of female adult mice so that genes are expressed from only one X chromosome. In a Perspective, [Clerc and Avner][1] describe an elegant series of experiments in mouse embryos cloned from adult and embryonic female cell nuclei ([ Eggan et al. ][2]) that reveal how the inactivation state of
Philippe Clerc, Philip Avner
openaire +1 more source
Histone acetylation and X inactivation
Developmental Genetics, 1998In mammals, the levels of X-linked gene products in males and females are equalised by the silencing, early in development, of most of the genes on one of the two female X chromosomes. Once established, the silent state is stable from one cell generation to the next. In eutherian mammals, the inactive X chromosome (Xi) differs from its active homologue
A M, Keohane +3 more
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X-inactivation in Fabry disease
Gene, 2012Fabry disease is one of three X-linked lysosomal disorders. Because of X-chromosome inactivation (XCI), wherein there is (random) transcriptional silencing of one of the X-chromosomes in each female cell, females are mosaic for the expression of (some) X-linked genes. Thus, based on penetrance and expression, some females heterozygous for Fabry disease
Deborah, Elstein +3 more
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