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Transient colocalization of X-inactivation centres accompanies the initiation of X inactivation
Nature Cell Biology, 2006The initial differential treatment of the two X chromosomes during X-chromosome inactivation is controlled by the X-inactivation centre (Xic). This locus determines how many X chromosomes are present in a cell ('counting') and which X chromosome will be inactivated in female cells ('choice'). Critical control sequences in the Xic include the non-coding
Christian P, Bacher +7 more
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CpG Islands in Human X‐Inactivation
Annals of Human Genetics, 2003SummarySequence comparison analyses have been carried out for 19 genes escaping X‐inactivation versus 73 genes subject to X‐inactivation, and 100 randomly chosen X chromosome genes versus 100 randomly chosen autosomal genes. The coding sequence of the genes and their upstream and downstream flanking sequences were investigated using a series of windows
Ke, X., Collins, A.
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Potato Virus X Inactivation and Characterization
2023The nucleoprotein components of plant viruses self-assemble into monodisperse, nanoscale structures with a high degree of symmetry and polyvalency. Of particular interest are the filamentous plant viruses which provide uniform high aspect ratio nanostructures-such structures remain challenging to obtain using purely synthetic approaches. Potato virus X
Yifeng, Ma, Nicole F, Steinmetz
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X-changing information on X inactivation
Experimental Cell Research, 2010In female somatic cells of mammalian species one X chromosome is inactivated to ensure dosage equality of X-encoded genes between females and males, during development and adulthood. X chromosome inactivation (XCI) involves various epigenetic mechanisms, including RNA mediated gene silencing in cis, DNA methylation, and changes in chromatin ...
Barakat, Stefan +3 more
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Skewed X-inactivation in cloned mice
Biochemical and Biophysical Research Communications, 2004In female mammals, dosage compensation for X-linked genes is accomplished by inactivation of one of two X chromosomes. The X-inactivation ratio (a percentage of the cells with inactivated maternal X chromosomes in the whole cells) is skewed as a consequence of various genetic mutations, and has been observed in a number of X-linked disorders.
Sho, Senda +7 more
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Mammalian Genome, 2000
In females, most genes on the inactive X Chromosome (Chr) are transcriptionally silenced. However, several dozen genes have been identified in human that escape inactivation and are expressed from both the active and inactive X Chrs. Many of the genes that escape inactivation in human are subject to inactivation in mouse, raising questions concerning ...
K D, Tsuchiya, H F, Willard
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In females, most genes on the inactive X Chromosome (Chr) are transcriptionally silenced. However, several dozen genes have been identified in human that escape inactivation and are expressed from both the active and inactive X Chrs. Many of the genes that escape inactivation in human are subject to inactivation in mouse, raising questions concerning ...
K D, Tsuchiya, H F, Willard
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X inactivation and epigenetics
ACM SIGGRAPH 2012 Computer Animation Festival, 2012X inactivation is a vital process that occurs in all DNA-containing cells of the female body. It is also an important research model and tool for studying biology. Epigenetics refers to processes that tell our cells how, and when, to read the DNA blueprint.
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Human molecular genetics, 1995
Initiation of X-inactivation is known to depend on the presence of a unique region or locus known as the X-inactivation center, or Xic, defined by the study of chromosomal rearrangements. Its mode of action is currently unknown but is the scene of much research effort.
E, Heard, P, Avner
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Initiation of X-inactivation is known to depend on the presence of a unique region or locus known as the X-inactivation center, or Xic, defined by the study of chromosomal rearrangements. Its mode of action is currently unknown but is the scene of much research effort.
E, Heard, P, Avner
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X inactivation, differentiation, and DNA methylation
Cytogenetic and Genome Research, 1975A model based on DNA methylation is proposed to explain the initiation and maintenance of mammalian X inactivation and certain aspects of other permanent events in eukaryotic cell differentiation. A key feature of the model is the proposal of sequence-specific DNA methylases that methylate unmethylated sites with great difficulty but easily methylate ...
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Skewed X Inactivation and Recurrent Spontaneous Abortion
Seminars in Reproductive Medicine, 2001Recent studies show that women experiencing recurrent spontaneous abortion exhibit nonrandom X-chromosome inactivation (XCI) more often than in controls. This suggests that genetic factors may be important in explaining the losses in this subset of women. Nonetheless there are a number of possible explanations for this finding and the underlying causes
W P, Robinson +3 more
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