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Genetics. Reprogramming X inactivation.
Science (New York, N.Y.), 2000Inactivation of one of the two X chromosomes occurs in all cells of female adult mice so that genes are expressed from only one X chromosome. In a Perspective, Clerc and Avner describe an elegant series of experiments in mouse embryos cloned from adult and embryonic female cell nuclei (Eggan et al.) that reveal how the inactivation state of the X ...
P, Clerc, P, Avner
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Heterochromatin and X Inactivation
2007Cytological examinations of nuclear structure in the early 1900s led to the discovery of heterochromatic regions that retain the deeply staining properties of metaphase chromatin throughout the cell cycle. The molecular determinants of heterochromatin have largely remained a mystery.
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The role of Xist in X-inactivation
Current Opinion in Genetics & Development, 1998The past year has seen important progress in our understanding of the role of the X inactive specific transcript gene (Xist) in the initiation and propagation of X-inactivation. A 35 kb Xist transgene had been shown to recapitulate the functions of the X-inactivation centre, progress has been made towards indentifying factors controlling the randomness
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