Results 141 to 150 of about 6,581,018 (264)
Active X-ray optics for the next generation of X-ray space telescopes [PDF]
, 2010 Described within is the design, manufacture, metrology and X-ray testing of an active X-ray prototype intended for the next generation of X-ray telescopes.
Atkins, C.
core
Enhancement of Dissymmetry Factors Through Axial Elongation of Hetero[n]helicenes
Angewandte Chemie, EarlyView.A benzofuran scaffolding strategy enables the synthesis of hetero[9]‐, [12]‐, and [15]helicenes. Structural and chiroptical analyses demonstrate that systematic axial elongation increases helical distortion and significantly amplifies luminescence dissymmetry.
Jeppe S. Mogensen +7 more
wiley +2 more sources
Evidence for a Cu(II)‐Catalysed CuAAC Reaction: A Combined Experimental and Computational Study
Angewandte Chemie, EarlyView.A new mechanistic pathway for the CuAAC reaction has been found to operate under specific reaction conditions. The pathway is catalysed by Cu(II) through a self‐assembled dinuclear Cu(II) complex that incorporates the triazole product. Computational analysis and assessment of generality are reported.
Matthew J. Andrews +12 more
wiley +2 more sources
Angewandte Chemie, EarlyView.BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu +19 more
wiley +2 more sources
Photoswitchable Ambiphilicity: Light‐Gated Frustrated Lewis Pair Reactivity and Z‐Type Interaction
Angewandte Chemie, EarlyView.Light‐controlled ambiphilicity is realized in photoswitchable intramolecular phosphorus/boron Lewis pairs. Reversible switching modulates both the thermodynamics and kinetics of frustrated Lewis‐pair reactivity, enabling light‐gated CO2 binding and release.
Lennart Stoess +3 more
wiley +2 more sources
In Vitro Selection of Functional Neoproteins Containing Highly Fluorinated Cores
Angewandte Chemie, EarlyView.The generation of neoproteins—functional proteins containing unnatural amino acids—is a key goal in synthetic biology. We develop a platform to discover neoproteins with specified bioactivity from trillion‐member sequence libraries, using genetic code reprogramming, in vitro selection and microwave peptide synthesis.
Adam Beattie +5 more
wiley +2 more sources
Structure and Function of a Multi‐Megadalton Virus‐Like Proteolytic Dodecahedron
Angewandte Chemie, EarlyView.Zuzalysin, a virulence metallopeptidase of the periodontal pathogen Porphyromonas gingivalis, is secreted as a latent, flexible ≈95‐kDa monomer. Calcium triggers cysteine‐switch activation and hierarchical assembly into pentamers, bipentamers, tripentamers, and a ≈5.6‐MDa, ≈355‐Å dodecahedron. Structures at 1.8–3.6 Å reveal a virus‐sized catalytic cage
Mariusz Madej +20 more
wiley +2 more sources
Convergent-beam X-ray crystallography. [PDF]
J Appl CrystallogrLi C +21 more
europepmc +1 more source
Angewandte Chemie, EarlyView.We report the computational design of de novo proteins that bind Mn(salen)‐based complexes (L1) using Rosetta FastDesign and verified by AlphaFold2. After screening, the catalytic activity for the promising design (dnMSBP) toward enantioselective sulfoxidation of thioanisole was optimized based on its crystal structure. With 10 different substrates, we
Jing‐Xiang Wang +6 more
wiley +2 more sources